Search Results - "Tumang, J"

CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway by Schattner, E J, Elkon, K B, Yoo, D H, Tumang, J, Krammer, P H, Crow, M K, Friedman, S M

“…The Apo-1/Fas antigen (CD95) mediates programmed cell death of lymphocytes when bound by Fas ligand or anti-Apo-1/Fas antibody. In contrast, the CD40 antigen…”
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c-Rel Is Required for the Protection of B Cells from Antigen Receptor-Mediated, But Not Fas-Mediated, Apoptosis by Owyang, Alexander M, Tumang, Joseph R, Schram, Brian R, Hsia, Constance Y, Behrens, Timothy W, Rothstein, Thomas L, Liou, Hsiou-Chi

“…The NF-kappaB/Rel transcription factor family has been shown to protect many cell types from apoptotic signals. However, it is not known whether NF-kappaB is…”
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Helper T cell-dependent human B cell differentiation mediated by a mycoplasmal superantigen bridge by TUMANG, J. R, POSNETT, D. N, COLE, B. C, CROW, M. K, FRIEDMAN, S. M

“…Experimentally induced murine graft-vs.-host disease may be characterized by hypergammaglobulinemia, autoantibody formation, and immune complex-mediated organ…”
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T helper cell-dependent, microbial superantigen-induced murine B cell activation: polyclonal and antigen-specific antibody responses by Tumang, JR, Cherniack, EP, Gietl, DM, Cole, BC, Russo, C, Crow, MK, Friedman, SM

“…Microbial superantigens (SA), bound to human B cell surface MHC class II molecules, have been shown to promote direct, "cognate" interaction with SA-reactive…”
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Microbial superantigens as etiopathogenic agents in autoimmunity by Friedman, S M, Tumang, J R, Crow, M K

“…A recently characterized group of immunologically active microbial products, termed superantigens, may provide the etiopathogenic link between antecedent…”
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T helper cell-dependent, microbial superantigen-mediated B cell activation in vivo by Tumang, J R, Zhou, J L, Gietl, D, Crow, M K, Elkon, K B, Friedman, S M

“…We have utilized a severe combined immune-deficient (SCID) mouse adoptive transfer model to explore the in vivo immunostimulatory effects of bacterial…”
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Human B cell differentiation induced by microbial superantigens: unselected peripheral blood lymphocytes secrete polyclonal immunoglobulin in response to Mycoplasma arthritidis mitogen by Crow, M K, Zagon, G, Chu, Z, Ravina, B, Tumang, J R, Cole, B C, Friedman, S M

“…Microbial superantigens (SA) activate a significant portion of the T cell repertoire based on their dual avidity for MHC class II antigens and T cell receptor…”
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c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function by Liou, Hsiou-Chi, Jin, Zhuang, Tumang, Joseph, Andjelic, Sofija, Smith, Kendall A., Liou, Mei-Ling

“…The TCR signals are essential for T cell activation and proliferation, primarily through the induction of cytokine and cytokine receptors. Several…”
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CD5 +/Mac-1 − peritoneal B cells: A novel B cell subset that exhibits characteristics of B-1 cells by Hastings, William D., Gurdak, Sean M., Tumang, Joseph R., Rothstein, Thomas L.

“…The peritoneal cavity of mice is enriched for B-1 B cells, a lymphocyte subset that differs from conventional B-2 cells phenotypically, functionally, and…”
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c‐Rel is essential for B lymphocyte survival and cell cycle progression by Tumang, Joseph R., Owyang, Alexander, Andjelic, Sofija, Jin, Zhuang, Hardy, Richard R., Liou, Mei‐Ling, Liou, Hsiou‐Chi

“…c‐Rel is a lymphoid‐specific member of the NF‐κB / Rel family of transcriptional factors. To investigate the role of c‐Rel in B lymphocyte function, we…”
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Extreme skewing of annexin II and S100A6 expression identified by proteomic analysis of peritoneal B-1 cells by Francés, Rubén, Tumang, Joseph R., Rothstein, Thomas L.

“…B-1 cells differ phenotypically, biochemically and functionally from conventional B-2 cells. The origin of these differences remains uncertain. We hypothesized…”
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CD5 super(+)/Mac-1 super(-) peritoneal B cells: A novel B cell subset that exhibits characteristics of B-1 cells by Hastings, W D, Gurdak, S M, Tumang, J R, Rothstein, T L

“…The peritoneal cavity of mice is enriched for B-1 B cells, a lymphocyte subset that differs from conventional B-2 cells phenotypically, functionally, and…”
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A potential role for microbial superantigens in the pathogenesis of systemic autoimmune disease by Friedman, S M, Posnett, D N, Tumang, J R, Cole, B C, Crow, M K

“…We have attempted herein to demonstrate how microbial superantigens could promote an abnormal form of "cognate" T helper-B cell interaction, analogous to that…”
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C-type lectin OCILRP2/Clr-g and its ligand NKRP1f costimulate T cell proliferation and IL-2 production by Tian, Wenzhi, Nunez, Rafael, Cheng, Shuhua, Ding, Yumei, Tumang, Joseph, Lyddane, Clay, Roman, Christopher, Liou, Hsiou-Chi

“…We are reporting the identification of a novel C-type lectin receptor–ligand pair that is involved in T cell costimulation. The receptor, OCILRP2/Clr-g, is…”
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IL-6 rescues the hyporesponsiveness of c-Rel deficient B cells independent of Bcl-xL, Mcl-1, and Bcl-2 by Tumang, Joseph R, Hsia, Constance Y, Tian, Wenzhi, Bromberg, Jacqueline F, Liou, Hsiou-Chi

“…The hematopoietically restricted member of the NF-κB/Rel family, c-Rel, is essential for B cell survival and proliferation. Here we demonstrate that the…”
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BCR Engagement Induces Fas Resistance in Primary B Cells in the Absence of Functional Bruton's Tyrosine Kinase by Tumang, Joseph R, Negm, Robert S, Solt, Laura A, Schneider, Thomas J, Colarusso, Thomas P, Hastings, William D, Woodland, Robert T, Rothstein, Thomas L

“…B cell susceptibility to Fas-mediated apoptosis is regulated in a receptor-specific fashion. CD40 engagement produces marked sensitivity to Fas killing,…”
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CDR3 sequence motifs shared by oligoclonal rheumatoid arthritis synovial T cells. Evidence for an antigen-driven response by Li, Y, Sun, G R, Tumang, J R, Crow, M K, Friedman, S M

“…T lymphocytes reactive with as yet undefined joint-localized foreign or autoantigens may be important in the pathogenesis of RA. Molecular studies…”
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Characterization of human T cells reactive with the Mycoplasma arthritidis-derived superantigen (MAM): generation of a monoclonal antibody against V beta 17, the T cell receptor gene product expressed by a large fraction of MAM-reactive human T cells by Friedman, S M, Crow, M K, Tumang, J R, Tumang, M, Xu, Y Q, Hodtsev, A S, Cole, B C, Posnett, D N

“…While all known microbial superantigens are mitogenic for human peripheral blood lymphocytes (PBL), the functional response induced by Mycoplasma…”
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Characterization of human T cells reactive with the Mycoplasma arthritidis-derived superantigen (MAM) : generation of a monoclonal antibody against Vβ17, the T cell receptor gene product expressed by a large fraction of MAM-reactive human T cells by FRIEDMAN, S. M, CROW, M. K, TUMANG, J. R, TUMANG, M, YIQING XU, HODTSEV, A. S, COLE, B. C, POSNETT, D. N

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CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway by Schattner, E J, Elkon, K B, Yoo, Dae-Hyun, Tumang, J, Krammer, PH, Crow, M K, Friedman, S M

“…The Apo-1/Fas antigen (CD95) mediates programmed cell death of lymphocytes when bound by Fas ligand or anti-Apo-1/Fas antibody. In contrast, the CD40 antigen…”
Get full text