Search Results - "Tullis, Joshua S."

The development of new carboxylic acid-based MMP inhibitors derived from a cyclohexylglycine scaffold by Tullis, Joshua S., Laufersweiler, Matthew J., VanRens, John C., Natchus, Michael G., Bookland, Roger G., Almstead, Neil G., Pikul, Stanislaw, De, Biswanath, Hsieh, Lily C., Janusz, Michael J., Branch, Todd M., Peng, Sean X., Jin, Yingkun Y., Hudlicky, Tomas, Oppong, Kofi

“…A series of carboxylic acids was prepared based on cyclohexylglycine scaffolds and tested for potency as matrix metalloproteinase (MMP) inhibitors. Detailed…”
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The development of new triazole based inhibitors of tumor necrosis factor-α (TNF-α) production by Tullis, Joshua S, VanRens, John C, Natchus, Michael G, Clark, Michael P, De, Biswanath, Hsieh, Lily C, Janusz, Michael J

“…4-Aryl-5-pyridyl and 4-aryl-5-pyrimidyl based inhibitors of TNF-α production, which contain a novel triazole 5-member heterocyclic core, are described. Many…”
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Solid-phase synthesis of functionalized 1,2,3-triazoles by Blass, Benjamin E, Coburn, Keith R, Faulkner, Amy L, Hunn, Cheryl L, Natchus, Michael G, Parker, M.Sharon, Portlock, David E, Tullis, Joshua S, Wood, Richard

“…Functionalized 1,2,3-triazoles are prepared by 2+3 cycloaddition of resin bound α-azido esters with substituted alkynes. The reaction is regioselective when…”
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Reagent Control of Geometric Selectivity and Enantiotopic Group Preference in Asymmetric Horner−Wadsworth−Emmons Reactions with meso-Dialdehydes by Tullis, Joshua S, Vares, Lauri, Kann, Nina, Norrby, Per-Ola, Rein, Tobias

“…Results from asymmetric Horner−Wadsworth−Emmons reactions between chiral phosphonate reagents 3a − d, which contain (1R,2S,5R)-8-phenylmenthol as a chiral…”
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Synthetic Applications of Asymmetric Horner-Wadsworth-Emmons Condensations: Approaches to Marine Natural Products by Tullis, Joshua S., Helquist, Paul, Rein, Tobias

“…Asymmetric HWE condensations of meso-dialdehyde 1 with chiral phosphonates containing 8-phenylmenthol very directly generate chiral moieties that are seen in a…”
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