Search Results - "Tullis, D Elizabeth"

Lung microbiota across age and disease stage in cystic fibrosis by Coburn, Bryan, Wang, Pauline W., Diaz Caballero, Julio, Clark, Shawn T., Brahma, Vijaya, Donaldson, Sylva, Zhang, Yu, Surendra, Anu, Gong, Yunchen, Elizabeth Tullis, D., Yau, Yvonne C. W., Waters, Valerie J., Hwang, David M., Guttman, David S.

“…Understanding the significance of bacterial species that colonize and persist in cystic fibrosis (CF) airways requires a detailed examination of bacterial…”
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Selective Sweeps and Parallel Pathoadaptation Drive Pseudomonas aeruginosa Evolution in the Cystic Fibrosis Lung by Diaz Caballero, Julio, Clark, Shawn T, Coburn, Bryan, Zhang, Yu, Wang, Pauline W, Donaldson, Sylva L, Tullis, D Elizabeth, Yau, Yvonne C W, Waters, Valerie J, Hwang, David M, Guttman, David S

“…Pulmonary infections caused by Pseudomonas aeruginosa are a recalcitrant problem in cystic fibrosis (CF) patients. While the clinical implications and…”
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Phenotypic diversity within a Pseudomonas aeruginosa population infecting an adult with cystic fibrosis by Clark, Shawn T., Diaz Caballero, Julio, Cheang, Mary, Coburn, Bryan, Wang, Pauline W., Donaldson, Sylva L., Zhang, Yu, Liu, Mingyao, Keshavjee, Shaf, Yau, Yvonne C.W., Waters, Valerie J., Elizabeth Tullis, D., Guttman, David S., Hwang, David M.

“…Chronic airway infections caused by Pseudomonas aeruginosa contribute to the progression of pulmonary disease in individuals with cystic fibrosis (CF). In the…”
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Recovery of lung function following a pulmonary exacerbation in patients with cystic fibrosis and the G551D-CFTR mutation treated with ivacaftor by Flume, Patrick A., Wainwright, Claire E., Elizabeth Tullis, D., Rodriguez, Sally, Niknian, Minoo, Higgins, Mark, Davies, Jane C., Wagener, Jeffrey S.

“…Pulmonary exacerbations (PEx) are associated with acute loss of lung function that is often not recovered after treatment. We investigated lung function…”
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Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of the Transcriptional Repressor Nrg1 as a Mechanism of Pathogen Adaptation by Kim, Sang Hu, Clark, Shawn T, Surendra, Anuradha, Copeland, Julia K, Wang, Pauline W, Ammar, Ron, Collins, Cathy, Tullis, D Elizabeth, Nislow, Corey, Hwang, David M, Guttman, David S, Cowen, Leah E

“…The microbiome shapes diverse facets of human biology and disease, with the importance of fungi only beginning to be appreciated. Microbial communities…”
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A genome-wide association analysis reveals a potential role for recombination in the evolution of antimicrobial resistance in Burkholderia multivorans by Diaz Caballero, Julio, Clark, Shawn T, Wang, Pauline W, Donaldson, Sylva L, Coburn, Bryan, Tullis, D Elizabeth, Yau, Yvonne C W, Waters, Valerie J, Hwang, David M, Guttman, David S

“…Cystic fibrosis (CF) lung infections caused by members of the Burkholderia cepacia complex, such as Burkholderia multivorans, are associated with high rates of…”
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Analysis of the cystic fibrosis lung microbiota via serial Illumina sequencing of bacterial 16S rRNA hypervariable regions by Maughan, Heather, Wang, Pauline W, Diaz Caballero, Julio, Fung, Pauline, Gong, Yunchen, Donaldson, Sylva L, Yuan, Lijie, Keshavjee, Shaf, Zhang, Yu, Yau, Yvonne C W, Waters, Valerie J, Tullis, D Elizabeth, Hwang, David M, Guttman, David S

“…The characterization of bacterial communities using DNA sequencing has revolutionized our ability to study microbes in nature and discover the ways in which…”
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Microbiome networks and change-point analysis reveal key community changes associated with cystic fibrosis pulmonary exacerbations by Layeghifard, Mehdi, Li, Hannah, Wang, Pauline W., Donaldson, Sylva L., Coburn, Bryan, Clark, Shawn T., Caballero, Julio Diaz, Zhang, Yu, Tullis, D. Elizabeth, Yau, Yvonne C. W., Waters, Valerie, Hwang, David M., Guttman, David S.

“…Over 90% of cystic fibrosis (CF) patients die due to chronic lung infections leading to respiratory failure. The decline in CF lung function is greatly…”
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Clinical manifestations of cystic fibrosis among patients with diagnosis in adulthood by Gilljam, Marita, Ellis, Lynda, Corey, Mary, Zielenski, Julian, Durie, Peter, Tullis, D Elizabeth

“…To define the clinical characteristics and diagnostic parameters of patients with cystic fibrosis (CF) diagnosed in adulthood. Retrospective cohort study…”
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Feasibility of internet-based health-related quality of life data collection in a large patient cohort by Bhinder, Sacha, Chowdhury, Noori, Granton, John, Krahn, Murray, Tullis, D Elizabeth, Waddell, Thomas K, Singer, Lianne G

“…Patient registries are commonly used to track survival and medical outcomes in large cohorts. However, large-scale collection of health-related quality of life…”
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Clinical Outcomes Associated with Achromobacter Species Infection in Patients with Cystic Fibrosis by Somayaji, Ranjani, Stanojevic, Sanja, Tullis, D Elizabeth, Stephenson, Anne L, Ratjen, Felix, Waters, Valerie

“…Achromobacter species are increasingly identified in individuals with cystic fibrosis (CF), but the clinical outcomes in these patients remain poorly…”
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Effects of Recipient Age and Diagnosis on Health-related Quality-of-Life Benefit of Lung Transplantation by Singer, Lianne G, Chowdhury, Noori A, Faughnan, Marie E, Granton, John, Keshavjee, Shaf, Marras, Theodore K, Tullis, D Elizabeth, Waddell, Thomas K, Tomlinson, George

“…The average age of lung transplant recipients is increasing, and the mix of recipient indications for transplantation is changing. To determine whether the…”
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Triaging Access to Critical Care Resources in Patients With Chronic Respiratory Diseases in the Event of a Major COVID-19 Surge: Key Highlights From the Canadian Thoracic Society (CTS) Position Statement by Gupta, Samir, Batt, Jane, Bourbeau, Jean, Chapman, Kenneth R., Gershon, Andrea, Granton, John, Hambly, Nathan, Hernandez, Paul, Kolb, Martin, Mehta, Sanjay, Mielniczuk, Lisa, Provencher, Steeve, Stephenson, Anne L., Swiston, John, Tullis, D. Elizabeth, Vozoris, Nicholas T., Wald, Joshua, Weatherald, Jason, Bhutani, Mohit

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Pulmonary Bacterial Communities in Surgically Resected Noncystic Fibrosis Bronchiectasis Lungs Are Similar to Those in Cystic Fibrosis by Cunningham, Kristopher S., Maughan, Heather, Wang, Pauline W., Zhang, Yu, Cypel, Marcelo, Chaparro, Cecilia, Tullis, D. Elizabeth, Waddell, Thomas K., Keshavjee, Shaf, Liu, Mingyao, Guttman, David S., Hwang, David M.

“…Background. Recurrent bacterial infections play a key role in the pathogenesis of bronchiectasis, but conventional microbiologic methods may fail to identify…”
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Penicillin-binding protein 3 is a common adaptive target among Pseudomonas aeruginosa isolates from adult cystic fibrosis patients treated with β-lactams by Clark, Shawn T., Sinha, Utkarshna, Zhang, Yu, Wang, Pauline W., Donaldson, Sylva L., Coburn, Bryan, Waters, Valerie J., Yau, Yvonne C.W., Tullis, D. Elizabeth, Guttman, David S., Hwang, David M.

“…•pbpB is a common adaptive target among β-lactam exposed cystic fibrosis Pseudomonas aeruginosa isolates•Infecting cystic fibrosis Pseudomonas aeruginosa…”
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Continuous alternating inhaled antibiotics for chronic pseudomonal infection in cystic fibrosis by Flume, Patrick A, Clancy, John P, Retsch-Bogart, George Z, Tullis, D. Elizabeth, Bresnik, Mark, Derchak, P. Alex, Lewis, Sandra A, Ramsey, Bonnie W

“…Abstract Background Inhaled antibiotics are standard of care for treating chronic pseudomonal respiratory infections in cystic fibrosis patients, initially…”
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Inhaled aztreonam for chronic Burkholderia infection in cystic fibrosis: A placebo-controlled trial by Tullis, D. Elizabeth, Burns, Jane L, Retsch-Bogart, George Z, Bresnik, Mark, Henig, Noreen R, Lewis, Sandra A, LiPuma, John J

“…Abstract Background Individuals with Burkholderia spp. infection have historically been excluded from efficacy trials of inhaled antibiotics, including…”
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The repeatability of forced expiratory volume measurements in adults with cystic fibrosis by Stanbrook, Matthew B, Corey, Mary, Tullis, D Elizabeth

“…To determine the repeatability of measurements of FEV(1) in adults with lung disease due to cystic fibrosis (CF). Single cohort study nested within a…”
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Epidemiology of Clonal Pseudomonas aeruginosa Infection in a Canadian Cystic Fibrosis Population by Middleton, Maggie A, Layeghifard, Mehdi, Klingel, Michelle, Stanojevic, Sanja, Yau, Yvonne C W, Zlosnik, James E A, Coriati, Adele, Ratjen, Felix A, Tullis, Elizabeth D, Stephenson, Anne, Wilcox, Pearce, Freitag, Andreas, Chilvers, Mark, McKinney, Martha, Lavoie, Annick, Wang, Pauline W, Guttman, David S, Waters, Valerie J

“…The extent of the genetic relatedness among Pseudomonas aeruginosa isolates and its impact on clinical outcomes in the cystic fibrosis (CF) population is…”
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Navigating social and ethical challenges of biobanking for human microbiome research by Chuong, Kim H, Hwang, David M, Tullis, D Elizabeth, Waters, Valerie J, Yau, Yvonne C W, Guttman, David S, O'Doherty, Kieran C

“…Biobanks are considered to be key infrastructures for research development and have generated a lot of debate about their ethical, legal and social…”
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