Search Results - "Tulla‐Puche, Judit"

General Fmoc‐Based Solid‐Phase Synthesis of Complex Depsipeptides Circumventing Problematic Fmoc Removal by Lobo‐Ruiz, Ariadna, Tulla‐Puche, Judit

“…Development of an Fmoc‐based solid‐phase depsipeptide methodology has been hampered by base‐promoted fragmentation and diketoperazine formation upon Fmoc group…”
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A Lasso‐Inspired Bicyclic Peptide: Synthesis, Structure and Properties by Martin‐Gómez, Helena, Albericio, Fernando, Tulla‐Puche, Judit

“…The chemical synthesis of a bicycle inspired by the natural lasso peptide sungsanpin using a combination of solid‐phase and in‐solution chemistries is…”
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2-Methoxy-4-methylsulfinylbenzyl: A Backbone Amide Safety-Catch Protecting Group for the Synthesis and Purification of Difficult Peptide Sequences by Paradís-Bas, Marta, Tulla-Puche, Judit, Albericio, Fernando

“…The use of 2‐methoxy‐4‐methylsulfinylbenzyl (Mmsb) as a new backbone amide‐protecting group that acts as a safety‐catch structure is proposed. Mmsb, which is…”
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The road to the synthesis of "difficult peptides" by Paradís-Bas, Marta, Tulla-Puche, Judit, Albericio, Fernando

“…The last decade has witnessed a renaissance of peptides as drugs. This progress, together with advances in the structural behavior of peptides, has attracted…”
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ChemMatrix® for complex peptides and combinatorial chemistry by García-Ramos, Yésica, Paradís-Bas, Marta, Tulla-Puche, Judit, Albericio, Fernando

“…CM resin is a totally PEG‐based resin, made exclusively from primary ether bonds and therefore highly chemically stable. Compared to other PEG resins, it…”
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Optimized Fmoc solid-phase synthesis of the cysteine-rich peptide linaclotide by Góngora-Benítez, Miriam, Tulla-Puche, Judit, Paradís-Bas, Marta, Werbitzky, Oleg, Giraud, Matthieu, Albericio, Fernando

“…Linaclotide, a small 14‐mer peptide highly rich in cysteines, is currently in phase III clinical trials for the treatment of gastrointestinal disorders. The…”
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Polymers and drug delivery systems by Vilar, Gemma, Tulla-Puche, Judit, Albericio, Fernando

“…In the treatment of health related dysfunctions, it is desirable that the drug reaches its site of action at a particular concentration and that this…”
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Protection by Conformationally Restricted Mobility: First Solid-Phase Synthesis of Triostin A by Tulla-Puche, Judit, Marcucci, Eleonora, Fermin, Manuel, Bayó-Puxan, Núria, Albericio, Fernando

“…Conformationally restricted mobility: The application of an efficient solid‐phase strategy based on protection by conformationally restricted mobility (see…”
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Total Solid-Phase Synthesis of the Azathiocoraline Class of Symmetric Bicyclic Peptides by Bayó-Puxan, Núria, Fernández, Ariadna, Tulla-Puche, Judit, Riego, Estela, Cuevas, Carmen, Álvarez, Mercedes, Albericio, Fernando

“…Thiocoraline is a potent antitumor agent isolated from the marine organism Micromonospora sp. This symmetric bicyclic depsipeptide binds the minor groove of…”
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"Head-to-side-chain" cyclodepsipeptides of marine origin by Pelay-Gimeno, Marta, Tulla-Puche, Judit, Albericio, Fernando

“…Since the late 1980s, a large number of depsipeptides that contain a new topography, referred to as "head-to-side-chain" cyclodepsipeptides, have been isolated…”
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Investigation of the Biosynthesis of the Lasso Peptide Chaxapeptin Using an E. coli-Based Production System by Martin-Gómez, Helena, Linne, Uwe, Albericio, Fernando, Tulla-Puche, Judit, Hegemann, Julian D

“…Lasso peptides are natural products belonging to the family of ribosomally synthesized and posttranslationally modified peptides (RiPPs) and are defined by…”
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Solid-Phase Synthesis of NMe-IB-01212, a Highly N-Methylated Cyclic Peptide by Marcucci, Eleonora, Tulla-Puche, Judit, Albericio, Fernando

“…N-Methylation of peptides is an important synthetic tool in peptide-based medicinal chemistry. Herein, an optimized strategy for solid-phase synthesis of small…”
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Chemical Modification of Microcin J25 Reveals New Insights on the Stereospecific Requirements for Antimicrobial Activity by Martin-Gómez, Helena, Jorba, Marta, Albericio, Fernando, Viñas, Miguel, Tulla-Puche, Judit

“…In this study, microcin J25, a potent antimicrobial lasso peptide that acts on Gram-negative bacteria, was subjected to a harsh treatment with a base in order…”
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Eco-Friendly Combination of the Immobilized PGA Enzyme and the S-Phacm Protecting Group for the Synthesis of Cys-Containing Peptides by Góngora-Benítez, Miriam, Basso, Alessandra, Bruckdorfer, Thomas, Royo, Miriam, Tulla-Puche, Judit, Albericio, Fernando

“…Enzyme‐labile protecting groups have emerged as a green alternative to conventional protecting groups. These groups introduce a further orthogonal dimension…”
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The first total synthesis of the cyclodepsipeptide pipecolidepsin A by Pelay-Gimeno, Marta, García-Ramos, Yésica, Jesús Martin, Maria, Spengler, Jan, Molina-Guijarro, José Manuel, Munt, Simon, Francesch, Andrés M., Cuevas, Carmen, Tulla-Puche, Judit, Albericio, Fernando

“…Pipecolidepsin A is a head-to-side-chain cyclodepsipeptide isolated from the marine sponge Homophymia lamellosa . This compound shows relevant cytotoxic…”
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Stellatolides, a New Cyclodepsipeptide Family from the Sponge Ecionemia acervus: Isolation, Solid-Phase Total Synthesis, and Full Structural Assignment of Stellatolide A by Martín, María Jesús, Rodríguez-Acebes, Raquel, García-Ramos, Yésica, Martínez, Valentín, Murcia, Carmen, Digón, Isabel, Marco, Isabel, Pelay-Gimeno, Marta, Fernández, Rogelio, Reyes, Fernando, Francesch, Andrés M, Munt, Simon, Tulla-Puche, Judit, Albericio, Fernando, Cuevas, Carmen

“…The marine environment is a rich source of metabolites with potential therapeutic properties and applications for humans. Here we describe the first isolation,…”
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Back Cover: 2-Methoxy-4-methylsulfinylbenzyl: A Backbone Amide Safety-Catch Protecting Group for the Synthesis and Purification of Difficult Peptide Sequences (Chem. Eur. J. 46/2014) by Paradís-Bas, Marta, Tulla-Puche, Judit, Albericio, Fernando

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Acid-Labile Cys-Protecting Groups for the Fmoc/tBu Strategy: Filling the Gap by Góngora-Benítez, Miriam, Mendive-Tapia, Lorena, Ramos-Tomillero, Iván, Breman, Arjen C, Tulla-Puche, Judit, Albericio, Fernando

“…To address the existing gap in the current set of acid-labile Cys-protecting groups for the Fmoc/tBu strategy, diverse Fmoc-Cys(PG)-OH derivatives were…”
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RADA-16: A Tough Peptide - Strategies for Synthesis and Purification by Paradís-Bas, Marta, Tulla-Puche, Judit, Zompra, Aikaterini A., Albericio, Fernando

“…The self‐assembling capacity of certain molecules can be exploited for a diverse range of biomedical applications. The ionic complementary peptide RADA‐16 is…”
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Enzyme-Labile Protecting Groups for the Synthesis of Natural Products: Solid-Phase Synthesis of Thiocoraline by Tulla-Puche, Judit, Góngora-Benítez, Miriam, Bayó-Puxan, Núria, Francesch, Andrés M., Cuevas, Carmen, Albericio, Fernando

“…Another (orthogonal) dimension: The solid‐phase synthesis of thiocoraline was accomplished for the first time by a combined approach involving chemical and…”
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