Research of Radioprotective Agents from the Class of Natural Antioxidants

Research of Radioprotective Agents from the Class of Natural Antioxidants

After discovering oxygen, part of the air necessary for life, its toxicity was established, as it is involved in forming the reactive oxygen intermediates [1,2,3,4] which participate in the process of oxidative modification of macromolecules followed by the formation of toxic oxidation products: ald...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences and research Vol. 11; no. 2; pp. 653 - 655
Main Authors: Nizamov, Ramzi N, Konyukhov, Gennady V, Tarasova, Natalya B, Yunusov, Ilnar R, Vasilevsky, Nikolai M, Tuhfatullin, Marsel Z, Vagin, Konstantin N
Format: Journal Article
Language:English
Published: Cuddalore Journal of Pharmaceutical Sciences and Research 01-02-2019
Subjects:
Aging
Animals
Antioxidants
Biology
Cardiovascular disease
Disease prevention
Enzymes
Experiments
Free radicals
Hematology
Immunology
Laboratories
Medical research
Oxidation
Pathology
Raw materials
Sheep
Simulation
Test systems
New York
Russia
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Summary:After discovering oxygen, part of the air necessary for life, its toxicity was established, as it is involved in forming the reactive oxygen intermediates [1,2,3,4] which participate in the process of oxidative modification of macromolecules followed by the formation of toxic oxidation products: aldehydes, epoxides, unsaturated fatty acids, lipid radicals, malondialdehyde, ethane, methane, etc. The effect of the "Era-N" agent on the animal body was evaluated using clinical and hematological parameters, content of hemoglobin, erythrocytes, thrombocytes, T-, Blymphocytes, T-helpers, T-suppressors, nonspecific resistance indicators (lysozyme and bactericidal activity, phagocytic activity of neutrophils), bone marrow and spleen cellularity, as well as stress protective action in the immobilization test. [...]of the comparative analysis of different schemes of agent use, it was found that the most convenient and efficient one is parenteral (subcutaneous) use of the developed agent both before (24 h) and after (24 h) irradiation of animals, which ensured the survival of 75% of mice receiving the agent in the preventive variant (group I). Increased survival of lethally irradiated laboratory and farm (sheep) animals against the background of medical and preventive use of "Era-ZhM" agent was accompanied by a lighter clinical course of acute radiation sickness; less inhibition of the content of leukocytes (1.6 times), erythrocytes, lymphocytes compared with irradiated animals without treatment (Table 2); reduced activity of antioxidant enzymes while inhibiting the concentration of superoxide radicals.
ISSN:0975-1459