Search Results - "Tugwood, J."

Prognostic value of circulating tumour cells in limited-stage small-cell lung cancer: analysis of the concurrent once-daily versus twice-daily radiotherapy (CONVERT) randomised controlled trial by Tay, R.Y., Fernández-Gutiérrez, F., Foy, V., Burns, K., Pierce, J., Morris, K., Priest, L., Tugwood, J., Ashcroft, L., Lindsay, C.R., Faivre-Finn, C., Dive, C., Blackhall, F.

“…The clinical significance of circulating tumour cells (CTCs) in limited-stage small-cell lung cancer (LS-SCLC) is not well defined. We report a planned…”
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Physiological, pharmacological and toxicological considerations of drug‐induced structural cardiac injury by Cross, M J, Berridge, B R, Clements, P J M, Cove‐Smith, L, Force, T L, Hoffmann, P, Holbrook, M, Lyon, A R, Mellor, H R, Norris, A A, Pirmohamed, M, Tugwood, J D, Sidaway, J E, Park, B K

“…The incidence of drug‐induced structural cardiotoxicity, which may lead to heart failure, has been recognized in association with the use of anthracycline…”
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A phase Ib and randomised phase II trial of pazopanib with or without fosbretabulin in advanced recurrent ovarian cancer by Morgan, R.D., Jayson, G.C., Banerjee, S., Clamp, A.R., Lyon, A.R., Ryder, W.D., Hutson, R., Mescallado, N., Orbegoso Aguilar, C., Taylor, S., Tugwood, J., Hall, M., Dive, C., Rustin, G.J.S.

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The significance of circulating tumour cells in breast cancer: A review by Castle, J, Shaker, H, Morris, K, Tugwood, J.D, Kirwan, C.C

“…Abstract Haematogenous spread of circulating tumour cells (CTCs) is the principle mechanism for development of metastases. Research into the enumeration and…”
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Peroxisome proliferator-activated receptor alpha: role in rodent liver cancer and species differences by Holden, PR, Tugwood, JD

“…Peroxisome proliferators (PPs) are chemicals of industrial and pharmaceutical importance that elicit liver carcinogenesis by a non-genotoxic mechanism. One of…”
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1: Circulating tumour cells from small cell lung cancer patients are tumourigenic by Hodgkinson, C, Morrow, C, Tugwood, J, Li, Y, Metcalf, R, Rothwell, D, Trapani, F, Burt, D, Simpson, K, Morris, K, Pepper, S, Nonaka, D, Greystoke, A, Kelly, P, Bola, B, Polanski, R, Krebs, M, Antonello, J, Ayub, M, Faulkner, S, Priest, L, Carter, L, Tate, C, Miller, C, Blackhall, F, Brady, G, Dive, C

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The peroxisome proliferator-activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs by Issemann, I, Prince, R A, Tugwood, J D, Green, S

“…The peroxisome proliferator-activated receptor (PPAR) is a member of the steroid hormone receptor superfamily and is activated by a variety of fibrate…”
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Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription by Aldridge, T C, Tugwood, J D, Green, S

“…We have identified a peroxisome proliferator response element (PPRE) approx. 4300 nucleotide upstream of the rat cytochrome P-450 CYP4A1 gene. Two members of…”
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The Principles and Practice of Toxicogenomics: Applications and Opportunities by Pennie, William D., Tugwood, Jonathan D., Oliver, Gerry J. A., Kimber, Ian

“…The last decade has seen major developments in large-scale genome sequencing and in the development of technical platforms to support this. Several genomes,…”
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The peroxisome proliferator (PP) response element upstream of the human acyl CoA oxidase gene is inactive among a sample human population: significance for species differences in response to PPs by Woodyatt, N.J., Lambe, K.G., Myers, K.A., Tugwood, J.D., Roberts, R.A.

“…Peroxisome proliferators (PP) cause peroxisome proliferation, associated with rodent hepatocyte growth perturbation and hepatocarcinogenesis. However, in…”
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The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene by Tugwood, J.D., Issemann, I., Anderson, R.G., Bundell, K.R., McPheat, W.L., Green, S.

“…Peroxisome proliferators are a diverse group of chemicals, including several hypolipidaemic drugs, that activate a nuclear hormone receptor termed the…”
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Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPARα) by ROBERTS, R. A, JAMES, N. H, WOODYATT, N. J, MACDONALD, N, TUGWOOD, J. D

“…Peroxisome proliferators (PPs) are a class of nongenotoxic rodent hepatocarcinogens. We have demonstrated previously that PPs suppress both spontaneous rat…”
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Mechanistically-based human hazard assessment of peroxisome proliferator-induced hepatocarcinogenesis by Ashby, J, Brady, A, Elcombe, C R, Elliott, B M, Ishmael, J, Odum, J, Tugwood, J D, Kettle, S, Purchase, I F

“…In this review we have evaluated the relationship between peroxisome proliferation and hepatocarcinogenesis. To do so, we identified all chemicals known to…”
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Predictive models of hepatotoxicity using gene expression data from primary rat hepatocytes by Hultin-Rosenberg, L., Jagannathan, S., Nilsson, K. C., Matis, S. A., Sjögren, N., Huby, R. D. J., Salter, A. H., Tugwood, J. D.

“…With the aim of evaluating the usefulness of an in vitro system for assessing the potential hepatotoxicity of compounds, the paper describes several methods of…”
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The retinoid X receptor enhances the function of the peroxisome proliferator activated receptor by Issemann, I, Prince, R A, Tugwood, J D, Green, S

“…The peroxisome proliferator activated receptor (PPAR) is a member of the steroid hormone receptor superfamily and is activated by a variety of non-genotoxic…”
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Peroxisome proliferator-activated receptors: structures and function by Tugwood, J D, Aldridge, T C, Lambe, K G, Macdonald, N, Woodyatt, N J

“…We have been attempting to elucidate the molecular mechanisms through which peroxisome proliferators exert their pleiotropic effects, with particular emphasis…”
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Two families of sequences in the small RNA-encoding region of Epstein-Barr virus (EBV) correlate with EBV types A and B by ARRAND, J. R, YOUNG, L. S, TUGWOOD, J. D

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Molecular analysis of even-skipped mutants in Drosophila development by FRASCH, M, WARRIOR, R, TUGWOOD, J, LEVINE, M

“…The homeo box gene even-skipped (eve) plays a key role in the regulation of the Drosophila segmentation pattern. eve- embryos lack segment borders and show…”
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Peroxisome proliferator-activated receptor (PPAR) alpha-regulated growth responses and their importance to hepatocarcinogenesis by James, N.H, Gill, J.H, Brindle, R, Woodyatt, N.J, Macdonald, N, Rolfe, M, Hasmall, S.C, Tugwood, J.D, Holden, P.R, Roberts, R.A

“…Peroxisome proliferators (PPs) are a class of non-genotoxic rodent hepatocarcinogens that act by perturbing liver growth regulation. We have demonstrated…”
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A Human Peroxisome‐Proliferator‐Activated Receptor‐γ is Activated by Inducers of Adipogenesis, Including Thiazolidinedione Drugs by Lambe, Kevin G., Tugwood, Jonathan D.

“…We have cloned a human cognate of the mouse peroxisome‐proliferator‐activated receptor‐γ (hPPARγ) from a human placenta cDNA library. Sequence analysis reveals…”
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