Search Results - "Tugaeva, Kristina V"

Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms by Gogl, Gergo, Tugaeva, Kristina V., Eberling, Pascal, Kostmann, Camille, Trave, Gilles, Sluchanko, Nikolai N.

“…The seven 14-3-3 isoforms are highly abundant human proteins encoded by similar yet distinct genes. 14-3-3 proteins recognize phosphorylated motifs within…”
Get full text

Bacterial co-expression of human Tau protein with protein kinase A and 14-3-3 for studies of 14-3-3/phospho-Tau interaction by Tugaeva, Kristina V, Tsvetkov, Philipp O, Sluchanko, Nikolai N

“…Abundant regulatory 14-3-3 proteins have an extremely wide interactome and coordinate multiple cellular events via interaction with specifically phosphorylated…”
Get full text

Effect of Betaine and Arginine on Interaction of αB-Crystallin with Glycogen Phosphorylase b by Eronina, Tatiana B, Mikhaylova, Valeriya V, Chebotareva, Natalia A, Tugaeva, Kristina V, Kurganov, Boris I

“…Protein-protein interactions (PPIs) play an important role in many biological processes in a living cell. Among them chaperone-client interactions are the most…”
Get full text

DNA-targeting short Argonautes complex with effector proteins for collateral nuclease activity and bacterial population immunity by Prostova, Maria, Kanevskaya, Anna, Panteleev, Vladimir, Lisitskaya, Lidia, Perfilova Tugaeva, Kristina V., Sluchanko, Nikolai N., Esyunina, Daria, Kulbachinskiy, Andrey

“…Two prokaryotic defence systems, prokaryotic Argonautes (pAgos) and CRISPR–Cas, detect and cleave invader nucleic acids using complementary guides and the…”
Get full text

Counterbalance of Stability and Activity Observed for Thermostable Transaminase from Thermobaculum terrenum in the Presence of Organic Solvents by Ekaterina Yu. Bezsudnova, Alena Yu. Nikolaeva, Sergey Y. Kleymenov, Tatiana E. Petrova, Sofia A. Zavialova, Kristina V. Tugaeva, Nikolai N. Sluchanko, Vladimir O. Popov

“…Pyridoxal-5’-phosphate-dependent transaminases catalyze stereoselective amination of organic compounds and are highly important for industrial applications…”
Get full text

The Mechanism of SARS-CoV-2 Nucleocapsid Protein Recognition by the Human 14-3-3 Proteins by Tugaeva, Kristina V., Hawkins, Dorothy E.D.P., Smith, Jake L.R., Bayfield, Oliver W., Ker, De-Sheng, Sysoev, Andrey A., Klychnikov, Oleg I., Antson, Alfred A., Sluchanko, Nikolai N.

“…[Display omitted] •SARS-CoV-2 nucleocapsid protein (N) binds to all seven human 14-3-3 isoforms.•This association with 14-3-3 strictly depends on…”
Get full text

Crystal structure of human 14-3-3ζ complexed with the noncanonical phosphopeptide from proapoptotic BAD by Sluchanko, Nikolai N., Tugaeva, Kristina V., Gushchin, Ivan, Remeeva, Alina, Kovalev, Kirill, Cooley, Richard B.

“…Several signaling pathways control phosphorylation of the proapoptotic protein BAD and its phosphorylation-dependent association with 14-3-3 proteins in the…”
Get full text

Molecular basis for the recognition of steroidogenic acute regulatory protein by the 14‐3‐3 protein family by Tugaeva, Kristina V., Titterington, James, Sotnikov, Dmitriy V., Maksimov, Eugene G., Antson, Alfred A., Sluchanko, Nikolai N.

“…The human STARD1 protein supplies cholesterol to the mitochondria to initiate steroidogenesis. STARD1 functioning is regulated by binding to the 14‐3‐3…”
Get full text

Structural basis for the recognition by 14-3-3 proteins of a conditional binding site within the oligomerization domain of human nucleophosmin by Kapitonova, Anna A., Tugaeva, Kristina V., Varfolomeeva, Larisa A., Boyko, Konstantin M., Cooley, Richard B., Sluchanko, Nikolai N.

“…Nucleophosmin 1 (NPM1) is a multifunctional protein regulating ribosome biogenesis, centrosome duplication and chromatin remodeling. Being a major nucleolar…”
Get full text

Human 14-3-3 Proteins Site-selectively Bind the Mutational Hotspot Region of SARS-CoV-2 Nucleoprotein Modulating its Phosphoregulation by Tugaeva, Kristina V., Sysoev, Andrey A., Kapitonova, Anna A., Smith, Jake L.R., Zhu, Phillip, Cooley, Richard B., Antson, Alfred A., Sluchanko, Nikolai N.

“…[Display omitted] •S197 and T205 are mutually exclusive 14-3-3-binding phosphosites in SARS-CoV-2 N.•T205 is the preferred binding site by all seven human…”
Get full text

Solution structure of human steroidogenic acute regulatory protein STARD1 studied by small-angle X-ray scattering by Sluchanko, Nikolai N., Tugaeva, Kristina V., Maksimov, Eugene G.

“…Intracellular cholesterol transfer to mitochondria, a bottleneck of adrenal and gonadal steroidogenesis, relies on the functioning of the steroidogenic acute…”
Get full text

Chimeric 14-3-3 proteins for unraveling interactions with intrinsically disordered partners by Sluchanko, Nikolai N., Tugaeva, Kristina V., Greive, Sandra J., Antson, Alfred A.

“…In eukaryotes, several “hub” proteins integrate signals from different interacting partners that bind through intrinsically disordered regions. The 14-3-3…”
Get full text

Crystal structure reveals canonical recognition of the phosphorylated cytoplasmic loop of human alpha7 nicotinic acetylcholine receptor by 14-3-3 protein by Sluchanko, Nikolai N., Kapitonova, Anna A., Shulepko, Mikhail A., Kukushkin, Ilya D., Kulbatskii, Dmitrii S., Tugaeva, Kristina V., Varfolomeeva, Larisa A., Minyaev, Mikhail E., Boyko, Konstantin M., Popov, Vladimir O., Kirpichnikov, Mikhail P., Lyukmanova, Ekaterina N.

“…Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels composed of five homologous subunits. The homopentameric α7-nAChR, abundantly…”
Get full text

Design, expression, purification and crystallization of human 14-3-3ζ protein chimera with phosphopeptide from proapoptotic protein BAD by Tugaeva, Kristina V., Remeeva, Alina, Gushchin, Ivan, Cooley, Richard B., Sluchanko, Nikolai N.

“…14-3-3 protein isoforms regulate multiple processes in eukaryotes, including apoptosis and cell division. 14-3-3 proteins preferentially recognize…”
Get full text

Concatenation of 14-3-3 with partner phosphoproteins as a tool to study their interaction by Tugaeva, Kristina V., Kalacheva, Daria I., Cooley, Richard B., Strelkov, Sergei V., Sluchanko, Nikolai N.

“…Regulatory 14-3-3 proteins interact with a plethora of phosphorylated partner proteins, however 14-3-3 complexes feature intrinsically disordered regions and…”
Get full text

Effect of Trehalose on Oligomeric State and Anti-Aggregation Activity of αB-Crystallin by Chebotareva, Natalia A., Eronina, Tatiana B., Mikhaylova, Valeriya V., Roman, Svetlana G., Tugaeva, Kristina V., Kurganov, Boris I.

“…αB-Crystallin (αB-Cr), one of the main crystalline lens proteins, along with other crystallins maintains lens transparency suppressing protein aggregation and…”
Get full text

Effect of the NBD-group position on interaction of fluorescently-labeled cholesterol analogues with human steroidogenic acute regulatory protein STARD1 by Tugaeva, Kristina V., Faletrov, Yaroslav V., Allakhverdiev, Elvin S., Shkumatov, Vladimir M., Maksimov, Eugene G., Sluchanko, Nikolai N.

“…Steroidogenic acute regulatory protein (StAR, STARD1) is a key factor of intracellular cholesterol transfer to mitochondria, necessary for adrenal and gonadal…”
Get full text

High-yield soluble expression, purification and characterization of human steroidogenic acute regulatory protein (StAR) fused to a cleavable Maltose-Binding Protein (MBP) by Sluchanko, Nikolai N., Tugaeva, Kristina V., Faletrov, Yaroslav V., Levitsky, Dmitrii I.

“…Steroidogenic acute regulatory protein (StAR) is responsible for the rapid delivery of cholesterol to mitochondria where the lipid serves as a source for…”
Get full text

New 20-hydroxycholesterol-like compounds with fluorescent NBD or alkyne labels: Synthesis, in silico interactions with proteins and uptake by yeast cells by Faletrov, Yaroslav V., Efimova, Vera S., Horetski, Matvey S., Tugaeva, Kristina V., Frolova, Nina S., Lin, Quingquing, Isaeva, Ludmila V., Rubtsov, Mikhail A., Sluchanko, Nikolai N., Novikova, Ludmila A., Shkumatov, Vladimir M.

“…•20-oxysterol-like pregn-5-en-3β-ols with NBD or alkyne labels at C20 were synthesized.•The compounds show affine binding to some sterol-binding proteins in…”
Get full text

Effect of Trehalose on Oligomeric State and Anti-Aggregation Activity of [alpha]B-Crystallin by Chebotareva, Natalia A, Eronina, Tatiana B, Mikhaylova, Valeriya V, Roman, Svetlana G, Tugaeva, Kristina V, Kurganov, Boris I

“…[alpha]B-Crystallin ([alpha]B-Cr), one of the main crystalline lens proteins, along with other crystallins maintains lens transparency suppressing protein…”
Get full text