Search Results - "Tueting, P"

Epigenetic GABAergic targets in schizophrenia and bipolar disorder by Guidotti, A., Auta, J., Chen, Y., Davis, J.M., Dong, E., Gavin, D.P., Grayson, D.R., Matrisciano, F., Pinna, G., Satta, R., Sharma, R.P., Tremolizzo, L., Tueting, P.

“…It is becoming increasingly clear that a dysfunction of the GABAergic/glutamatergic network in telencephalic brain structures may be the pathogenetic mechanism…”
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Behavioral and molecular neuroepigenetic alterations in prenatally stressed mice: relevance for the study of chromatin remodeling properties of antipsychotic drugs by Dong, E, Tueting, P, Matrisciano, F, Grayson, D R, Guidotti, A

“…We have recently reported that mice born from dams stressed during pregnancy (PRS mice), in adulthood, have behavioral deficits reminiscent of behaviors…”
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An Epigenetic Mouse Model for Molecular and Behavioral Neuropathologies Related to Schizophrenia Vulnerability by Tremolizzo, L., Carboni, G., Ruzicka, W. B., Mitchell, C. P., Sugaya, I., Tueting, P., Sharma, R., Grayson, D. R., Costa, E., Guidotti, A.

“…Reelin and glutamic acid decarboxylase (GAD)67expressed by cortical γ-aminobutyric acid-ergic interneurons are down-regulated in schizophrenia. Because…”
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DNA-methylation gene network dysregulation in peripheral blood lymphocytes of schizophrenia patients by Auta, J, Smith, R.C, Dong, E, Tueting, P, Sershen, H, Boules, S, Lajtha, A, Davis, J, Guidotti, A

“…Abstract The epigenetic dysregulation of the brain genome associated with the clinical manifestations of schizophrenia (SZ) includes altered DNA promoter…”
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Toward the Identification of Peripheral Epigenetic Biomarkers of Schizophrenia by Guidotti, A., Auta, J., Davis, J. M., Dong, E., Gavin, D. P., Grayson, D. R., Sharma, R. P., Smith, R. C., Tueting, P., Zhubi, A.

“…Abstract Schizophrenia (SZ) is a heritable, nonmendelian, neurodevelopmental disorder in which epigenetic dysregulation of the brain genome plays a fundamental…”
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Enhanced dizocilpine efficacy in heterozygous reeler mice relates to GABA turnover downregulation by Carboni, G., Tueting, P., Tremolizzo, L., Sugaya, I., Davis, J., Costa, E., Guidotti, A.

“…Reelin synthesized by cortical GABAergic interneurons throughout the telencephalon is secreted into the extracellular matrix (ECM) and binds with nM affinity…”
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The P50 evoked potential component and mismatch detection in normal volunteers: implications for the study of sensory gating by Boutros, Nashaat N., Torello, Michael W., Barker, Brandy A., Tueting, Patricia A., Wu, Shu-Chieh, Nasrallah, Henry A.

“…Sensory gating is a complex, multistage, multifaceted physiological function believed to be protecting higher cortical centers from being flooded with incoming…”
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Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice by Tremolizzo, Lucio, Doueiri, Mohemed-Salim, Dong, Erbo, Grayson, Dennis R., Davis, John, Pinna, Graziano, Tueting, Patricia, Rodriguez-Menendez, Virginia, Costa, Erminio, Guidotti, Alessandro

“…Reelin and GAD 67 expression is downregulated in cortical interneurons of schizophrenia (SZ) patients. This downregulation is probably mediated by epigenetic…”
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Modeling the molecular epigenetic profile of psychosis in prenatally stressed mice by Guidotti, Alessandro, Dong, Erbo, Tueting, Patricia, Grayson, Dennis R

“…Based on postmortem brain studies, our overarching epigenetic hypothesis is that chronic schizophrenia (SZ) is a psychopathological condition involving…”
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Reelin down-regulation in mice and psychosis endophenotypes by Tueting, Patricia, Doueiri, Mohemed-Salim, Guidotti, Alessandro, Davis, John M., Costa, Erminio

“…Reelin, a large glycoprotein secreted by telencephalic GABAergic neurons, plays an important role in neuronal guidance embryonically and in synaptic plasticity…”
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A Decrease of Reelin Expression as a Putative Vulnerability Factor in Schizophrenia by Impagnatiello, Francesco, Guidotti, Alessandro R., Pesold, Christine, Dwivedi, Yogesh, Caruncho, Hector, Pisu, Maria G., Uzunov, Doncho P., Smalheiser, Neil R., Davis, John M., Pandey, Ghanshyam N., Pappas, George D., Tueting, Patricia, Sharma, Rajiv P., Costa, Erminio

“…Postmortem prefrontal cortices (PFC) (Brodmann's areas 10 and 46), temporal cortices (Brodmann's area 22), hippocampi, caudate nuclei, and cerebella of…”
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L-methionine decreases dendritic spine density in mouse frontal cortex by Tueting, Patricia, Davis, John M, Veldic, Marin, Pibiri, Fabio, Kadriu, Bashkim, Guidotti, Alessandro, Costa, Erminio

“…Schizophrenia postmortem brain is characterized by γ aminobutyric acid downregulation and by decreased dendritic spine density in frontal cortex. Protracted…”
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Psychophysiological predictors of drug treatment response by Tueting, P

“…Few of the psychophysiologic findings reviewed above are diagnostically specific. Not all persons given the same psychiatric diagnosis are likely to share the…”
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Investigational drugs and research by Tueting, P

“…This chapter will define investigational use for clinicians and outline FDA policies in this area in a simple and pragmatic way. Instances in which…”
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The phenotypic characteristics of heterozygous reeler mouse by Tueting, Patricia, Costa, Erminio, Dwivedi, Yogesh, Guidotti, Alessandro, Impagnatiello, Francesco, Manev, Radmila, Pesold, Christine

“…Histological and behavioral traits are associated with reelin (Reln) haplo-insufficiency in heterozygous reeler mouse (rl/+/−). These phenotypic traits are an,…”
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Emitted and evoked P300 potentials and variation in stimulus probability by Ruchkin, D S, Sutton, S, Tueting, P

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The heterozygote reeler mouse as a model for the development of a new generation of antipsychotics by Costa, Erminio, Davis, John, Pesold, Christine, Tueting, Patricia, Guidotti, Alessandro

“…Neurochemical and structural prefrontal cortex abnormalities, including decreased reelin and glutamic acid decarboxylase (GAD) 67 expression, decreased…”
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The effect of lithium on platelet monoamine oxidase activity in bipolar and schizoaffective disorders by Meltzer, H Y, Tueting, P, Jackman, H

“…Platelet monoamine oxidase (MAO) activity was studied in 33 in-patients with bipolar and schizoaffective disorder who were treated with lithium. Platelet MAO…”
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Auditory evoked potentials, clinical vs. research applications by Boutros, Nashaat, Nasrallah, Henry, Leighty, Robert, Torello, Michael, Tueting, Patricia, Olson, Stephen

“…Evidence of abnormal auditory evoked potentials (EPs) in patients suffering from schizophrenia has been accumulating. In spite of the magnitude of the EPs in…”
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5-lipoxygenase (5LOX)-deficient mice express reduced anxiety-like behavior by Uz, Tolga, Dimitrijevic, Nikola, Tueting, Patricia, Manev, Hari

“…5-Lipoxygenase (5LOX) is an enzyme critical for leukotriene synthesis from arachidonic acid. In addition to its role in peripheral inflammation, this enzyme is…”
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