Companion Animals Emerged as an Important Reservoir of Carbapenem-Resistant Enterobacteriaceae: A Report from India

Companion Animals Emerged as an Important Reservoir of Carbapenem-Resistant Enterobacteriaceae: A Report from India

The emergence and spread of carbapenem-resistant Enterobacteriaceae (CRE) are perceived as a serious public-health threat world-wide. Despite sporadic reports, no systemic study has been carried out on CRE in companion animals in Indian subcontinent. In total, 237 canine specimens collected from fiv...

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Published in:Current microbiology Vol. 78; no. 3; pp. 1006 - 1016
Main Authors: Bandyopadhyay, Samiran, Banerjee, Jaydeep, Bhattacharyya, Debaraj, Tudu, Rahul, Samanta, Indranil, Dandapat, Premanshu, Nanda, Pramod K., Das, Arun K., Mondal, Bimalendu, Batabyal, Subhasis, Dutta, Tapan K.
Format: Journal Article
Language:English
Published: New York Springer US 01-03-2021
Springer Nature B.V
Subjects:
Aminoglycosides
Animals
Anti-Bacterial Agents - pharmacology
Antibiotics
Antimicrobial resistance
Bacterial Proteins - genetics
beta-Lactamases - genetics
Biofilms
Biomedical and Life Sciences
Biotechnology
Carbapenem-Resistant Enterobacteriaceae - genetics
Carbapenems
Chromium
CRE bacteria
Dogs
E coli
Enterobacteriaceae
Enterobacteriaceae Infections - veterinary
Escherichia coli
Health risks
India
Life Sciences
Metallo-β-lactamase
Metallography
Microbial Sensitivity Tests
Microbiology
Pets
Plasmids
Public health
Sulfonamides
Virulence
β Lactamase
India
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Summary:The emergence and spread of carbapenem-resistant Enterobacteriaceae (CRE) are perceived as a serious public-health threat world-wide. Despite sporadic reports, no systemic study has been carried out on CRE in companion animals in Indian subcontinent. In total, 237 canine specimens collected from five veterinary polyclinics in and around Kolkata were analyzed for isolation, antimicrobial resistance profiling and molecular characterization of carbapenem-resistant (CR) E. coli . Of the 29 CR isolates, 19 were identified as metallo-β-lactamase producers (MP-CRE) and 10 as metallo-β-lactamase non-producers (MNP-CRE). Eleven of them were extended spectrum β-lactamase and/or AmpC type β-lactamase producers and harboured fluoroquinolone-, tetracycline-, sulfonamide- and aminoglycoside-resistant genes. Beside uropathogenic virulence determinants, they carried the adhesion factors mediating biofilm production which was remarkably higher in 6 MP-CRE and one MNP-CRE isolates. Although the CRE were of diverse origin including the healthy and the diseased dogs, these were more frequently isolated from canine pyometra. The MP-CRE harboured plasmids of IncF and Inc A/C types. Phylo-type B1 was observed in 38% of the CR isolates, followed by A0 in 31% and rest were attributed to A1 and D1. The Enterobacterial repetitive intergenic consensus-PCR (ERIC-PCR) revealed that these isolates were genetically diverse and constituted of a heterogenous population. Detection of CRE in pet dogs despite the fact that carbapenems are not used in animals in India emphasizes the need for active surveillance to identify the transmission and dynamics of such pathogens in companion animals.
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ISSN:0343-8651
1432-0991
DOI:10.1007/s00284-021-02355-6