Search Results - "Tudorascu, D. L."

When worry may be good for you: Worry severity and limbic-prefrontal functional connectivity in late-life generalized anxiety disorder by Wu, M, Mennin, DS, Ly, M, Karim, HT, Banihashemi, L, Tudorascu, DL, Aizenstein, HJ, Andreescu, C

“…•Emotional dysregulation explains GAD and pathologic worry.•We examined the effect of worry severity on limbic-prefrontal connectivity.•Moderate levels of…”
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An improved algorithm of white matter hyperintensity detection in elderly adults by Ding, T, Cohen, AD, O’Connor, EE, Karim, HT, Crainiceanu, A, Muschelli, J, Lopez, O, Klunk, WE, Aizenstein, HJ, Krafty, R, Crainiceanu, CM, Tudorascu, DL

“…•OASIS-AD is a method for automatic segmentation of white matter hyperintensities in older adults using structural brain MRIs.•OASIS-AD is an approach evolved…”
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In the grip of worry: cerebral blood flow changes during worry induction and reappraisal in late-life generalized anxiety disorder by Karim, H T, Tudorascu, D L, Butters, M A, Walker, S, Aizenstein, H J, Andreescu, C

“…Severe worry includes a complex blend of maladaptive affective and cognitive processes. Contrary to other forms of anxiety, there is no consensus in the field…”
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Relationship of amyloid beta and neurofibrillary tau deposition in Neurodegeneration in Aging Down Syndrome (NiAD) study at baseline by Tudorascu, DL, Laymon, CM, Zammit, M, Minhas, DS, Anderson, SJ, Ellison, PA, Zaman, S, Ances, BM, Sabbagh, M, Johnson, SC, Mathis, CA, Klunk, WE, Handen, BL, Christian, BT, Cohen, AD

“…Importance Adults with Down syndrome (DS) are at high‐risk of revealing Alzheimer's disease (AD) pathology, in part due to the triplication of chromosome 21…”
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Association between change in brain gray matter volume, cognition, and depression severity: Pre- and post- antidepressant pharmacotherapy for late-life depression by Droppa, K., Karim, H.T., Tudorascu, D.L., Karp, J.F., Reynolds, C.F., Aizenstein, H.J., Butters, M.A.

“…Late-life depression (LLD) is associated with cognitive impairments and reduced gray matter volume (GMV); however the mechanisms underlying this association…”
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In the grip of worry: cerebral blood flow changes during worry induction and reappraisal in late-life generalized anxiety disorder by Karim, H T, Tudorascu, D L, Butters, M A, Walker, S, Aizenstein, H J, Andreescu, C

“…This corrects the article DOI: 10.1038/tp.2017.180…”
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Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease by Bellaver, Bruna, Povala, Guilherme, Ferreira, Pamela C. L., Ferrari-Souza, João Pedro, Leffa, Douglas T., Lussier, Firoza Z., Benedet, Andréa L., Ashton, Nicholas J., Triana-Baltzer, Gallen, Kolb, Hartmuth C., Tissot, Cécile, Therriault, Joseph, Servaes, Stijn, Stevenson, Jenna, Rahmouni, Nesrine, Lopez, Oscar L., Tudorascu, Dana L., Villemagne, Victor L., Ikonomovic, Milos D., Gauthier, Serge, Zimmer, Eduardo R., Zetterberg, Henrik, Blennow, Kaj, Aizenstein, Howard J., Klunk, William E., Snitz, Beth E., Maki, Pauline, Thurston, Rebecca C., Cohen, Ann D., Ganguli, Mary, Karikari, Thomas K., Rosa-Neto, Pedro, Pascoal, Tharick A.

“…An unresolved question for the understanding of Alzheimer’s disease (AD) pathophysiology is why a significant percentage of amyloid-β (Aβ)-positive cognitively…”
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Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer’s disease by Ferrari-Souza, João Pedro, Ferreira, Pâmela C. L., Bellaver, Bruna, Tissot, Cécile, Wang, Yi-Ting, Leffa, Douglas T., Brum, Wagner S., Benedet, Andréa L., Ashton, Nicholas J., De Bastiani, Marco Antônio, Rocha, Andréia, Therriault, Joseph, Lussier, Firoza Z., Chamoun, Mira, Servaes, Stijn, Bezgin, Gleb, Kang, Min Su, Stevenson, Jenna, Rahmouni, Nesrine, Pallen, Vanessa, Poltronetti, Nina Margherita, Klunk, William E., Tudorascu, Dana L., Cohen, Ann D., Villemagne, Victor L., Gauthier, Serge, Blennow, Kaj, Zetterberg, Henrik, Souza, Diogo O., Karikari, Thomas K., Zimmer, Eduardo R., Rosa-Neto, Pedro, Pascoal, Tharick A.

“…Astrocytes can adopt multiple molecular phenotypes in the brain of Alzheimer’s disease (AD) patients. Here, we studied the associations of cerebrospinal fluid…”
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Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages by Pascoal, Tharick A, Benedet, Andrea L, Tudorascu, Dana L, Therriault, Joseph, Mathotaarachchi, Sulantha, Savard, Melissa, Lussier, Firoza Z, Tissot, Cécile, Chamoun, Mira, Kang, Min Su, Stevenson, Jenna, Massarweh, Gassan, Guiot, Marie-Christine, Soucy, Jean-Paul, Gauthier, Serge, Rosa-Neto, Pedro

“…Tracking longitudinal tau tangles accumulation across the Alzheimer's disease continuum is crucial to better understand the natural history of tau pathology…”
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Genetic risk for attention-deficit/hyperactivity disorder predicts cognitive decline and development of Alzheimer’s disease pathophysiology in cognitively unimpaired older adults by Leffa, Douglas T., Ferrari-Souza, João Pedro, Bellaver, Bruna, Tissot, Cécile, Ferreira, Pamela C. L., Brum, Wagner S., Caye, Arthur, Lord, Jodie, Proitsi, Petroula, Martins-Silva, Thais, Tovo-Rodrigues, Luciana, Tudorascu, Dana L., Villemagne, Victor L., Cohen, Ann D., Lopez, Oscar L., Klunk, William E., Karikari, Thomas K., Rosa-Neto, Pedro, Zimmer, Eduardo R., Molina, Brooke S. G., Rohde, Luis Augusto, Pascoal, Tharick A.

“…Attention-deficit/hyperactivity disorder (ADHD) persists in older age and is postulated as a risk factor for cognitive impairment and Alzheimer’s Disease (AD)…”
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Blood‐brain barrier integrity impacts the use of plasma amyloid‐β as a proxy of brain amyloid‐β pathology by Bellaver, Bruna, Puig‐Pijoan, Albert, Ferrari‐Souza, João Pedro, Leffa, Douglas T., Lussier, Firoza Z., Ferreira, Pamela C. L., Tissot, Cécile, Povala, Guilherme, Therriault, Joseph, Benedet, Andréa L., Ashton, Nicholas J., Servaes, Stijn, Chamoun, Mira, Stevenson, Jenna, Rahmouni, Nesrine, Vermeiren, Marie, Macedo, Arthur C., Fernández‐Lebrero, Aida, García‐Escobar, Greta, Navalpotro‐Gómez, Irene, Lopez, Oscar, Tudorascu, Dana L., Cohen, Ann, Villemagne, Victor L., Klunk, William E., Gauthier, Serge, Zimmer, Eduardo R., Karikari, Thomas K., Blennow, Kaj, Zetterberg, Henrik, Suárez‐Calvet, Marc, Rosa‐Neto, Pedro, Pascoal, Tharick A.

“…INTRODUCTION Amyloid‐β (Aβ) and tau can be quantified in blood. However, biological factors can influence the levels of brain‐derived proteins in the blood…”
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The Association of Age-Related and Off-Target Retention with Longitudinal Quantification of 18F MK6240 Tau PET in Target Regions by Tissot, C., Servaes, S., Lussier, F. Z., Ferrai-Souza, J. P., Therriault, J., Ferreirat, P. C., Bezgin, G., Bellaver, B., Leffa, D. T., Mathotaarachchi, S. S., Chamoun, M., Stevenson, J., Rahmouni, N., Kang, M. S., Pallen, V., Margherita-Poltronetti, N., Wang, Y. T., Fernandez-Arias, J., Lessa Benedet, Andréa, Zimmer, E. R., Soucy, J. P., Tudorascu, D. L., Cohen, A. D., Sharp, M., Gauthier, S., Massarweh, G., Lopresti, B., Klunk, W. E., Baker, S. L., Villemagne, V. L., Rosa-Neto, P., Pascoal, T. A.

“…6-(fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F] MK6240) tau PET tracer quantifies the brain tau neurofibrillary tangle load in…”
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Potential Utility of Plasma P-Tau and Neurofilament Light Chain as Surrogate Biomarkers for Preventive Clinical Trials by Ferreira, Pamela, Ferrari-Souza, João Pedro, Tissot, Cécile, Bellaver, Bruna, Leffa, Douglas, Lussier, Firoza, Povala, Guilherme, Therriault, Joseph, Benedet, Andréa L, Ashton, Nicholas J, Cohen, Ann D., Lopez, Oscar L., Tudorascu, Dana, Klunk, William E., Soucy, Jean-Paul, Gauthier, Serge, Villemagne, Victor, Zetterberg, Henrik, Blennow, Kaj, Rosa-Neto, Pedro, Zimmer, Eduardo R., Karikari, Thomas K, Pascoal, Tharick

“…To test the utility of longitudinal changes in plasma phosphorylated tau 181 (p-tau181) and neurofilament light chain (NfL) as surrogate markers for clinical…”
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Comparing tau status determined via plasma pTau181, pTau231 and [18F]MK6240 tau-PET by Tissot, Cécile, Therriault, Joseph, Kunach, Peter, L Benedet, Andréa, Pascoal, Tharick A., Ashton, Nicholas J., Karikari, Thomas K., Servaes, Stijn, Lussier, Firoza Z., Chamoun, Mira, Tudorascu, Dana L., Stevenson, Jenna, Rahmouni, Nesrine, Poltronetti, Nina Margherita, Pallen, Vanessa, Bezgin, Gleb, Kang, Min Su, Mathotaarachchi, Sulantha S., Wang, Yi-Ting, Fernandez Arias, Jaime, Ferreira, Pamela Cristina Lukasewicz, Ferrari-Souza, João Pedro, Vanmechelen, Eugeen, Blennow, Kaj, Zetterberg, Henrik, Gauthier, Serge, Rosa-Neto, Pedro

“…Tau in Alzheimer's disease (AD) is assessed via cerebrospinal fluid (CSF) and Positron emission tomography (PET). Novel methods to detect phosphorylated tau…”
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Plasma p-tau231 and p-tau217 inform on tau tangles aggregation in cognitively impaired individuals by Ferreira, Pamela C L, Therriault, Joseph, Tissot, Cécile, Ferrari-Souza, João Pedro, Benedet, Andréa L, Povala, Guilherme, Bellaver, Bruna, Leffa, Douglas T, Brum, Wagner S, Lussier, Firoza Z, Bezgin, Gleb, Servaes, Stijn, Vermeiren, Marie, Macedo, Arthur C, Cabrera, Arlec, Stevenson, Jenna, Triana-Baltzer, Gallen, Kolb, Hartmuth, Rahmouni, Nesrine, Klunk, William E, Lopez, Oscar L, Villemagne, Victor L, Cohen, Ann, Tudorascu, Dana L, Zimmer, Eduardo R, Karikari, Thomas K, Ashton, Nicholas J, Zetterberg, Henrik, Blennow, Kaj, Gauthier, Serge, Rosa-Neto, Pedro, Pascoal, Tharick A

“…Phosphorylated tau (p-tau) biomarkers have been recently proposed to represent brain amyloid-β (Aβ) pathology. Here, we evaluated the plasma biomarkers'…”
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Erratum: In the grip of worry: cerebral blood flow changes during worry induction and reappraisal in late-life generalized anxiety disorder by Karim, H T, Tudorascu, D L, Butters, M A, Walker, S, Aizenstein, H J, Andreescu, C

“…Correction to: Translational Psychiatry (2017) 7, e1204; doi:10.1038/tp.2017.180; published online 15 August 2017 On the penultimate line of Table 1, the last…”
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APOE ε4 associates with microglial activation independently of Aβ plaques and tau tangles by Ferrari-Souza, João Pedro, Lussier, Firoza Z, Leffa, Douglas T, Therriault, Joseph, Tissot, Cécile, Bellaver, Bruna, Ferreira, Pâmela C L, Malpetti, Maura, Wang, Yi-Ting, Povala, Guilherme, Benedet, Andréa L, Ashton, Nicholas J, Chamoun, Mira, Servaes, Stijn, Bezgin, Gleb, Kang, Min Su, Stevenson, Jenna, Rahmouni, Nesrine, Pallen, Vanessa, Poltronetti, Nina Margherita, O'Brien, John T, Rowe, James B, Cohen, Ann D, Lopez, Oscar L, Tudorascu, Dana L, Karikari, Thomas K, Klunk, William E, Villemagne, Victor L, Soucy, Jean-Paul, Gauthier, Serge, Souza, Diogo O, Zetterberg, Henrik, Blennow, Kaj, Zimmer, Eduardo R, Rosa-Neto, Pedro, Pascoal, Tharick A

“…Animal studies suggest that the apolipoprotein E ε4 ( ε4) allele is a culprit of early microglial activation in Alzheimer's disease (AD). Here, we tested the…”
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