Search Results - "Tuder, Rubin"

Pulmonary vascular remodeling in pulmonary hypertension by Tuder, Rubin M.

“…Pulmonary vascular remodeling is the key structural alteration in pulmonary hypertension and involves changes in the intima, media and adventitia, often with…”
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Pathogenesis of chronic obstructive pulmonary disease by Tuder, Rubin M, Petrache, Irina

“…The current epidemic of chronic obstructive pulmonary disease (COPD) has produced a worldwide health care burden, approaching that imposed by transmittable…”
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Relevant Issues in the Pathology and Pathobiology of Pulmonary Hypertension by Tuder, Rubin M., MD, Archer, Stephen L., MD, Dorfmüller, Peter, MD, PhD, Erzurum, Serpil C., MD, Guignabert, Christophe, PhD, Michelakis, Evangelos, MD, Rabinovitch, Marlene, MD, Schermuly, Ralph, PhD, Stenmark, Kurt R., MD, Morrell, Nicholas W., MD

“…Knowledge of the pathobiology of pulmonary hypertension (PH) continues to accelerate. However, fundamental gaps remain in our understanding of the underlying…”
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Pathobiology of Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease by Yoshida, Toshinori, Tuder, Rubin M

“…Division of Cardiopulmonary Pathology, Department of Pathology, and Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of…”
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Assessment of Right Ventricular Function in the Research Setting: Knowledge Gaps and Pathways Forward. An Official American Thoracic Society Research Statement by Lahm, Tim, Douglas, Ivor S, Archer, Stephen L, Bogaard, Harm J, Chesler, Naomi C, Haddad, Francois, Hemnes, Anna R, Kawut, Steven M, Kline, Jeffrey A, Kolb, Todd M, Mathai, Stephen C, Mercier, Olaf, Michelakis, Evangelos D, Naeije, Robert, Tuder, Rubin M, Ventetuolo, Corey E, Vieillard-Baron, Antoine, Voelkel, Norbert F, Vonk-Noordegraaf, Anton, Hassoun, Paul M

“…Right ventricular (RV) adaptation to acute and chronic pulmonary hypertensive syndromes is a significant determinant of short- and long-term outcomes. Although…”
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Progress in solving the sex hormone paradox in pulmonary hypertension by Lahm, Tim, Tuder, Rubin M, Petrache, Irina

“…Pulmonary arterial hypertension (PAH) is a devastating and progressive disease with marked morbidity and mortality. Even though being female represents one of…”
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Bringing Light to Chronic Obstructive Pulmonary Disease Pathogenesis and Resilience by Tuder, Rubin M

“…The pathogenesis of chronic obstructive pulmonary disease remains elusive; investigators in the field have struggled to decipher the cellular and molecular…”
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Dynamic and diverse changes in the functional properties of vascular smooth muscle cells in pulmonary hypertension by Stenmark, Kurt R, Frid, Maria G, Graham, Brian B, Tuder, Rubin M

“…Abstract Pulmonary hypertension (PH) is the end result of interaction between pulmonary vascular tone and a complex series of cellular and molecular events…”
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Telomere dysfunction causes alveolar stem cell failure by Alder, Jonathan K., Barkauskas, Christina E., Limjunyawong, Nathachit, Stanley, Susan E., Kembou, Frant, Tuder, Rubin M., Hogan, Brigid L. M., Mitzner, Wayne, Armanios, Mary

“…Significance Idiopathic pulmonary fibrosis and emphysema are leading causes of mortality, but there are no effective therapies. Mutations in telomerase are the…”
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Pathology of pulmonary arterial hypertension by Tuder, Rubin M

“…The pathological features of pulmonary arterial hypertension are highlighted in this review, which can serve as a guide to diagnosis and identification of…”
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Metabolic reprogramming and inflammation act in concert to control vascular remodeling in hypoxic pulmonary hypertension by Stenmark, Kurt R, Tuder, Rubin M, El Kasmi, Karim C

“…Pulmonary hypertension (PH) is a complex, multifactorial syndrome that remains poorly understood despite decades of research. PH is characterized by profound…”
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The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis by Schmidt, Eric P, Yang, Yimu, Janssen, William J, Gandjeva, Aneta, Perez, Mario J, Barthel, Lea, Zemans, Rachel L, Bowman, Joel C, Koyanagi, Dan E, Yunt, Zulma X, Smith, Lynelle P, Cheng, Sara S, Overdier, Katherine H, Thompson, Kathy R, Geraci, Mark W, Douglas, Ivor S, Pearse, David B, Tuder, Rubin M

“…The glycocalyx is a layer of proteoglycans and complex carbohydrates that lines the endothelial cell surface in blood vessels. Schmidt et al . show that in…”
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Targeting Energetic Metabolism A New Frontier in the Pathogenesis and Treatment of Pulmonary Hypertension by TUDER, Rubin M, DAVIS, Laura A, GRAHAM, Brian B

“…This perspective highlights advances in the understanding of the role of cellular metabolism in the pathogenesis of pulmonary hypertension. Insights gained in…”
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Inhaled seralutinib exhibits potent efficacy in models of pulmonary arterial hypertension by Galkin, Anna, Sitapara, Ravikumar, Clemons, Bryan, Garcia, Eduardo, Kennedy, Michael, Guimond, David, Carter, Laura L, Douthitt, Ashley, Osterhout, Robin, Gandjeva, Aneta, Slee, Deborah, Salter-Cid, Luisa, Tuder, Rubin M, Zisman, Lawrence S

“…Signalling through platelet-derived growth factor receptor (PDGFR), colony-stimulating factor 1 receptor (CSF1R) and mast/stem cell growth factor receptor kit…”
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Modern Age Pathology of Pulmonary Arterial Hypertension by STACHER, Elvira, GRAHAM, Brian B, TUDER, Rubin M, HUNT, James M, GANDJEVA, Aneta, GROSHONG, Steve D, MCLAUGHLIN, Vallerie V, JESSUP, Marsha, GRIZZLE, William E, ALDRED, Michaela A, COOL, Carlyne D

“…The impact of modern treatments of pulmonary arterial hypertension (PAH) on pulmonary vascular pathology remains unknown. To assess the spectrum of pulmonary…”
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Experimental Schistosoma japonicum-induced pulmonary hypertension by Kassa, Biruk, Lee, Michael H, Kumar, Rahul, Mickael, Claudia, Sanders, Linda, Tuder, Rubin M, Mentink-Kane, Margaret, Graham, Brian B

“…Schistosomiasis, a major cause of pulmonary arterial hypertension (PAH) worldwide, is most clearly described complicating infection by one species, Schistosoma…”
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Unbiased Quantitation of Alveolar Type II to Alveolar Type I Cell Transdifferentiation during Repair after Lung Injury in Mice by Jansing, Nicole L, McClendon, Jazalle, Henson, Peter M, Tuder, Rubin M, Hyde, Dallas M, Zemans, Rachel L

“…The alveolar epithelium consists of squamous alveolar type (AT) I and cuboidal ATII cells. ATI cells cover 95-98% of the alveolar surface, thereby playing a…”
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Mammalian Target of Rapamycin Complex 2 (mTORC2) Coordinates Pulmonary Artery Smooth Muscle Cell Metabolism, Proliferation, and Survival in Pulmonary Arterial Hypertension by Goncharov, Dmitry A, Kudryashova, Tatiana V, Ziai, Houman, Ihida-Stansbury, Kaori, DeLisser, Horace, Krymskaya, Vera P, Tuder, Rubin M, Kawut, Steven M, Goncharova, Elena A

“…BACKGROUND—Enhanced proliferation, resistance to apoptosis, and metabolic shift to glycolysis of pulmonary arterial vascular smooth muscle cells (PAVSMCs) are…”
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Right Ventricle Vasculature in Human Pulmonary Hypertension Assessed by Stereology by Graham, Brian B, Koyanagi, Dan, Kandasamy, Balasubramaniyam, Tuder, Rubin M

“…Published data, reliant on measures of stained capillary area in selected RV fields, indicated a potential capillary drop, possibly of 50 or 60% versus control…”
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Lactate produced by alveolar type II cells suppresses inflammatory alveolar macrophages in acute lung injury by Roy, René M., Allawzi, Ayed, Burns, Nana, Sul, Christina, Rubio, Victoria, Graham, Jessica, Stenmark, Kurt, Nozik, Eva S., Tuder, Rubin M., Vohwinkel, Christine U.

“…Alveolar inflammation is a hallmark of acute lung injury (ALI), and its clinical correlate is acute respiratory distress syndrome—and it is as a result of…”
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