Search Results - "Tuddenham, E G"

Bernard Soulier syndrome in pregnancy: a systematic review by PEITSIDIS, P., DATTA, T., PAFILIS, I., OTOMEWO, O., TUDDENHAM, E. G. D., KADIR, R. A.

“…Bernard Soulier syndrome (BSS) is a rare disorder of platelets, inherited mainly as an autosomal recessive trait. It is characterised by qualitative and…”
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450 million years of hemostasis by Davidson, C. J., Tuddenham, E. G., McVey, J. H.

“…In mammalian blood coagulation, five proteases (factor VII [FVII]; factor IX [FIX]; factor X [FX]; protein C [PC] and prothrombin [PT]) act with five cofactors…”
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High prevalence of elevated factor VIII levels in patients referred for thrombophilia screening: role of increased synthesis and relationship to the acute phase reaction by O'Donnell, J, Tuddenham, E G, Manning, R, Kemball-Cook, G, Johnson, D, Laffan, M

“…A recent report from the Leiden Thrombophilia Survey identified high factor VIII activity levels as an independent risk factor for venous thromboembolism in a…”
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An interactive mutation database for human coagulation factor IX provides novel insights into the phenotypes and genetics of hemophilia B by Rallapalli, P. M., Kemball‐Cook, G., Tuddenham, E. G., Gomez, K., Perkins, S. J.

“…Summary Background Factor IX (FIX) is important in the coagulation cascade, being activated to FIXa on cleavage. Defects in the human F9 gene frequently lead…”
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Platelets are a safe way to deliver factor VIII. After 13 years of preclinical research it is now time for a clinical trial by Tuddenham, E. G.

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Enhanced thrombin generation in patients with cirrhosis‐induced coagulopathy by GATT, A., RIDDELL, A., CALVARUSO, V., TUDDENHAM, E. G., MAKRIS, M., BURROUGHS, A. K.

“…Background: Prothrombin time (PT) and the international normalized ratio (INR) are still routinely measured in patients with liver cirrhosis to ‘assess’ their…”
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Haemophilia A: mutation type determines risk of inhibitor formation by Schwaab, R, Brackmann, H H, Meyer, C, Seehafer, J, Kirchgesser, M, Haack, A, Olek, K, Tuddenham, E G, Oldenburg, J

“…The formation of factor VIII antibodies is a major problem for replacement therapy of haemophilia A patients. Antibodies occur in 5-30% of patients with severe…”
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HLA genotype of patients with severe haemophilia A due to intron 22 inversion with and without inhibitors of factor VIII by Oldenburg, J, Picard, J K, Schwaab, R, Brackmann, H H, Tuddenham, E G, Simpson, E

“…Molecular genetic studies have shown that development of antibodies to factor VIII (inhibitors) occurs most frequently in patients with severe haemophilia due…”
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Definition of the bleeding tendency in factor XI-deficient kindreds--a clinical and laboratory study by Bolton-Maggs, P H, Patterson, D A, Wensley, R T, Tuddenham, E G

“…Individuals with severe factor XI deficiency are prone to excessive bleeding after injury or surgery, but the existence of a haemorrhagic tendency in partial…”
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Crystal structure of the extracellular region of human tissue factor by Harlos, K, Martin, D. M. A, O'Brien, D. P, Jones, E. Y, Stuart, D. I, Polikarpov, I, Miller, A, Tuddenham, E. G. D, Boys, C. W. G

“…Tissue factor is a cell-surface glycoprotein receptor which initiates the blood coagulation cascade after vessel injury by interacting with blood clotting…”
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Bleeding symptoms in 27 Iranian patients with the combined deficiency of factor V and factor VIII by PEYVANDI, F, TUDDENHAM, E. G. D, AKHTARI, A. M, LAK, M, MANNUCCI, P. M

“…Inherited deficiency of factors V and VIII is the most frequent combined coagulation defect. The cases reported so far are mostly single cases or small series…”
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Factor VII and cardiovascular risk by Tuddenham, E G D

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Consensus protocol for the use of recombinant activated factor VII [eptacog alfa (activated); NovoSeven®] in elective orthopaedic surgery in haemophilic patients with inhibitors by GIANGRANDE, P. L. F., WILDE, J. T., MADAN, B., LUDLAM, C. A., TUDDENHAM, E. G. D., GODDARD, N. J., DOLAN, G., INGERSLEV, J.

“…Patients with haemophilia complicated by inhibitors have a significant burden of joint disease, which is associated with a negative impact on their quality of…”
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Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex by Ginsburg, David, Zhang, Bin, Cunningham, Michael A, Nichols, William C, Bernat, John A, Seligsohn, Uri, Pipe, Steven W, McVey, John H, Schulte-Overberg, Ursula, de Bosch, Norma B, Ruiz-Saez, Arlette, White, Gilbert C, Tuddenham, EGD, Kaufman, Randal J

“…Mutations in LMAN1 (also called ERGIC-53) result in combined deficiency of factor V and factor VIII (F5F8D), an autosomal recessive bleeding disorder…”
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The regulation of tissue factor mRNA in human endothelial cells in response to endotoxin or phorbol ester by CROSSMAN, D. C, CARR, D. P, TUDDENHAM, E. G. D, PEARSON, J. D, MCVEY, J. H

“…Tissue factor (TF) is the membrane-bound glycoprotein whose cofactor activity with factor VIIa causes activation of the extrinsic pathway of coagulation. The…”
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Optimizing warfarin reversal – an ex vivo study by GATT, A., RIDDELL, A., VAN VEEN, J. J., KITCHEN, S., TUDDENHAM, E. G., MAKRIS, M.

“…Background: Warfarin reversal is a common clinical situation. This is commonly performed using vitamin K and, depending on the urgency, fresh frozen plasma…”
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Surface plasmon resonance studies of the interaction between factor VII and tissue factor. Demonstration of defective tissue factor binding in a variant FVII molecule (FVII-R79Q) by O'Brien, D. P, Kemball-Cook, G, Hutchinson, A. M, Martin, D. M. A, Johnson, D. J. D, Byfield, P. G. H, Takamiya, O, Tuddenham, E. G. D, McVey, J. H

“…The blood coagulation cascade is initiated when vessel injury allows factor VII (FVII) to form a complex with tissue factor (TF). Complete deficiency of FVII…”
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Gene therapy for hemophilia? Gene therapy for hemophilia is both desirable and achievable in the near future by Tuddenham, E G D

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Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene by GRAHAM, A, PAPALOPULU, N, LORIMER, J, MCVEY, J. H, TUDDENHAM, E. G. D, KRUMLAUF, R

“…The Hox-2 locus on chromosome 11 represents one of the major clusters of homeo-box-containing genes in the mouse. We have identified two new members (Hox-2.6…”
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Factor VIII gene mutations found by a comparative study of SSCP, DGGE and CMC and their analysis on a molecular model of factor VIII protein by SCHWAAB, R, OLDENBURG, J, LALLOZ, M. R. A, SCHWAAB, U, PEMBERTON, S, HANFLAND, P, BRACKMANN, H.-H, TUDDENHAM, E. G. D, MICHAELIDES, K

“…Screening of the factor VIII (FVIII) gene which spans 186 kb and codes for 26 exons, was originally hampered by its size but is now feasible because rapid DNA…”
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