Search Results - "Tucker, John A."

Design and synthesis of cell potent BACE-1 inhibitors: Structure–activity relationship of P1′ substituents by Sealy, Jennifer M., Truong, Anh P., Tso, Luke, Probst, Gary D., Aquino, Jose, Hom, Roy K., Jagodzinska, Barbara M., Dressen, Darren, Wone, David W.G., Brogley, Louis, John, Varghese, Tung, Jay S., Pleiss, Michael A., Tucker, John A., Konradi, Andrei W., Dappen, Michael S., Toth, Gergely, Pan, Hu, Ruslim, Lany, Miller, Jim, Bova, Michael P., Sinha, Sukanto, Quinn, Kevin P., Sauer, John-Michael

“…Using structure-guided design, hydroxyethylamine BACE-1 inhibitors were optimized to nanomolar Aβ cellular inhibition with selectivity against cathepsin-D…”
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Broad-Spectrum Antiherpes Activities of 4-Hydroxyquinoline Carboxamides, a Novel Class of Herpesvirus Polymerase Inhibitors by OIEN, Nancee L, BRIDEAU, Roger J, VAILLANCOURT, Vallerie A, CLAYTON, Terrance L, TUCKER, John A, WATHEN, Michael W, HOPKINS, Todd A, WIEBER, Janet L, KNECHTEL, Mary L, SHELLY, John A, ANSTADT, Robert A, WELLS, Peter A, POORMAN, Roger A, HUANG, Audris

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Shimada Kenji: Scholar, Tinker, Reader: Selected Writings on the Intellectual History of Modern China by Joshua A. Fogel (review) by Tucker, John A

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Piperazinyl Oxazolidinone Antibacterial Agents Containing a Pyridine, Diazene, or Triazene Heteroaromatic Ring by Tucker, John A, Allwine, Debra A, Grega, Kevin C, Barbachyn, Michael R, Klock, Jennifer L, Adamski, Jenifer L, Brickner, Steven J, Hutchinson, Douglas K, Ford, Charles W, Zurenko, Gary E, Conradi, Robert A, Burton, Phillip S, Jensen, Randy M

“…Oxazolidinones are a novel class of synthetic antibacterial agents active against gram-positive organisms including methicillin-resistant Staphylococcus aureus…”
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Host-guest complexation. 48. Octol building blocks for cavitands and carcerands by Tunstad, Linda M, Tucker, John A, Dalcanale, Enrico, Weiser, Jurgen, Bryant, Judi A, Sherman, John C, Helgeson, Roger C, Knobler, Carolyn B, Cram, Donald J

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Design, Synthesis, and Crystal Structure of Hydroxyethyl Secondary Amine-Based Peptidomimetic Inhibitors of Human β-Secretase by Maillard, Michel C, Hom, Roy K, Benson, Timothy E, Moon, Joseph B, Mamo, Shumeye, Bienkowski, Michael, Tomasselli, Alfredo G, Woods, Danielle D, Prince, D. Bryan, Paddock, Donna J, Emmons, Thomas L, Tucker, John A, Dappen, Michael S, Brogley, Louis, Thorsett, Eugene D, Jewett, Nancy, Sinha, Sukanto, John, Varghese

“…The design and synthesis of a novel series of potent and cell permeable peptidomimetic inhibitors of the human β-secretase (BACE) are described. These…”
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Stereoselectivities of nucleophilic additions to cyclohexanones substituted by polar groups. Experimental investigation of reductions of trans-decalones and theoretical studies of cyclohexanone reductions. The influence of remote electrostatic effects by Wu, Yun Dong, Tucker, John A, Houk, K. N

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Design and Synthesis of Human Immunodeficiency Virus Entry Inhibitors: Sulfonamide as an Isostere for the α-Ketoamide Group by Lu, Rong-Jian, Tucker, John A, Zinevitch, Tatiana, Kirichenko, Olga, Konoplev, Vitalii, Kuznetsova, Svetlana, Sviridov, Sergey, Pickens, Jason, Tandel, Sagun, Brahmachary, Enugurthi, Yang, Yang, Wang, Jian, Freel, Stephanie, Fisher, Shelly, Sullivan, Alana, Zhou, Jiying, Stanfield-Oakley, Sherry, Greenberg, Michael, Bolognesi, Dani, Bray, Brian, Koszalka, Barney, Jeffs, Peter, Khasanov, Alisher, Ma, You-An, Jeffries, Cynthia, Liu, Changhui, Proskurina, Tatiana, Zhu, Tong, Chucholowski, Alexander, Li, Rongshi, Sexton, Connie

“…The crystal structures of many tertiary α-ketoamides reveal an orthogonal arrangement of the two carbonyl groups. Based on the hypothesis that the α-ketoamide…”
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Heterobiaryl Human Immunodeficiency Virus Entry Inhibitors by Lu, Rong-Jian, Tucker, John A, Pickens, Jason, Ma, You-An, Zinevitch, Tatiana, Kirichenko, Olga, Konoplev, Vitalii, Kuznetsova, Svetlana, Sviridov, Sergey, Brahmachary, Enugurthi, Khasanov, Alisher, Mikel, Charles, Yang, Yang, Liu, Changhui, Wang, Jian, Freel, Stephanie, Fisher, Shelly, Sullivan, Alana, Zhou, Jiying, Stanfield-Oakley, Sherry, Baker, Brian, Sailstad, Jeff, Greenberg, Michael, Bolognesi, Dani, Bray, Brian, Koszalka, Barney, Jeffs, Peter, Jeffries, Cynthia, Chucholowski, Alexander, Sexton, Connie

“…Previously disclosed HIV (human immunodeficiency virus) attachment inhibitors, exemplified by BMS 806 (formally BMS378806, 1), are characterized by a…”
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The BMJ’s activism will ultimately harm its reputation by Tucker, John A

“…Whether The BMJ is ultimately found to be on the "right" side of these issues, I believe that the inherent conflict of interest between the journal's putative…”
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Conflicts of interest are everywhere by Tucker, John A

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Pediatric Otolaryngology in the United States: Chevalier Jackson’s Legacy for the 21st Century by Tucker, John A., Reilly, Brian K., Tucker, Sean T., Reilly, James S.

“…Chevalier Jackson and his disciples in pediatric bronchology and esophagology strove to conquer the 3 great illnesses of the early 20th century: lye ingestion…”
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Posterior Commissure of the Human Larynx Revisited by Tucker, John A, Tucker, Sean T

“…Summary The existence of the posterior commissure (PC) of the human larynx has been disputed (Hirano M, Sato K, et al. The posterior glottis. Trans Am Laryngol…”
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Humanism in East Asian Confucian Contexts by Chun-chieh Huang (review) by Tucker, John A

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Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: Structure–activity relationship of P2′ substituents by Truong, Anh P., Probst, Gary D., Aquino, Jose, Fang, Larry, Brogley, Louis, Sealy, Jennifer M., Hom, Roy K., Tucker, John A., John, Varghese, Tung, Jay S., Pleiss, Michael A., Konradi, Andrei W., Sham, Hing L., Dappen, Michael S., Tóth, Gergley, Yao, Nanhua, Brecht, Eric, Pan, Hu, Artis, Dean R., Ruslim, Lany, Bova, Michael P., Sinha, Sukanto, Yednock, Ted A., Zmolek, Wes, Quinn, Kevin P., Sauer, John-Michael

“…Herein, we describe further evolution of hydroxyethylamine inhibitors of BACE-1 with enhanced permeability characteristics necessary for CNS penetration…”
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Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Structure–activity relationship of the aryl region by Probst, Gary D., Bowers, Simeon, Sealy, Jennifer M., Stupi, Brian, Dressen, Darren, Jagodzinska, Barbara M., Aquino, Jose, Gailunas, Andrea, Truong, Anh P., Tso, Luke, Xu, Ying-Zi, Hom, Roy K., John, Varghese, Tung, Jay S., Pleiss, Michael A., Tucker, John A., Konradi, Andrei W., Sham, Hing L., Jagodzinski, Jacek, Toth, Gergely, Brecht, Eric, Yao, Nanhua, Pan, Hu, Lin, May, Artis, Dean R., Ruslim, Lany, Bova, Michael P., Sinha, Sukanto, Yednock, Ted A., Gauby, Shawn, Zmolek, Wes, Quinn, Kevin P., Sauer, John-Michael

“…The structure–activity relationship of the prime region of hydroxyethylamine BACE inhibitors is described. Variation in the aryl linker region with 5- and…”
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Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease by Basi, Guriqbal S, Hemphill, Susanna, Brigham, Elizabeth F, Liao, Anna, Aubele, Danielle L, Baker, Jeanne, Barbour, Robin, Bova, Michael, Chen, Xiao-Hua, Dappen, Michael S, Eichenbaum, Tovah, Goldbach, Erich, Hawkinson, Jon, Lawler-Herbold, Rose, Hu, Kang, Hui, Terence, Jagodzinski, Jacek J, Keim, Pamela S, Kholodenko, Dora, Latimer, Lee H, Lee, Mike, Marugg, Jennifer, Mattson, Matthew N, McCauley, Scott, Miller, James L, Motter, Ruth, Mutter, Linda, Neitzel, Martin L, Ni, Huifang, Nguyen, Lan, Quinn, Kevin, Ruslim, Lany, Semko, Christopher M, Shapiro, Paul, Smith, Jenifer, Soriano, Ferdie, Szoke, Balazs, Tanaka, Kevin, Tang, Pearl, Tucker, John A, Ye, Xiacong Michael, Yu, Mei, Wu, Jing, Xu, Ying-Zi, Garofalo, Albert W, Sauer, John Michael, Konradi, Andrei W, Ness, Daniel, Shopp, George, Pleiss, Michael A, Freedman, Stephen B, Schenk, Dale

“…Inhibition of gamma-secretase presents a direct target for lowering Aβ production in the brain as a therapy for Alzheimer's disease (AD). However,…”
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Ma, Lin, Heidegger on East-West Dialogue: Anticipating the Event: New York: Routledge, 2008, xi + 268 pages by Tucker, John A.

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Te-ch'uan Jih-ben Lun-yü ch'üan-shih shih-lun by Tucker, John A.

“…(Early-Modern Japanese society and Song learning), a work that suggests that Chinese Confucianism, while not initially appropriate to Japanese social and…”
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Tracheobronchial Stenting in an Infant with an Anomalous Right Main Bronchus by DePasquale, Kalpana S., Tucker, John A., Wolfson, Barbara, Varlotta, Laurie

“…Congenital anomalies of the right main bronchi have not been fully described. Bronchial anomalies are usually asymptomatic unless they coexist with other…”
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