Search Results - "Tucker, Ian G."

Aniracetam does not improve working memory in neurologically healthy pigeons by Phillips, Hannah, McDowell, Arlene, Mielby, Birgitte S, Tucker, Ian G, Colombo, Michael

“…Understanding the effects of cognitive enhancing drugs is an important area of research. Much of the research, however, has focused on restoring memory…”
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An In Silico Knockout Model for Gastrointestinal Absorption Using a Systems Pharmacology Approach - Development and Application for Ketones by Shivva, Vittal, Tucker, Ian G, Duffull, Stephen B

“…Gastrointestinal absorption and disposition of ketones is complex. Recent work describing the pharmacokinetics (PK) of d-β-hydroxybutyrate (BHB) following oral…”
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Evaluation of an on-farm culture system for the detection of subclinical mastitis pathogens in dairy cattle by Saila, Susan, Bork, Olaf, Tucker, Ian G., Cranefield, Steve, Bryan, Mark A.

“…[Display omitted] •Evaluation of an on-farm culture test (OFCT) for subclinical mastitis in dairy cows.•The OFCT has high specificity and selectivity for…”
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Characterization of a Nanoparticulate Drug Delivery System Using Scanning Ion Occlusion Sensing by Yang, Lin, Broom, Murray F., Tucker, Ian G.

“…ABSTRACT Purpose To explore the application of scanning ion occlusion sensing (SIOS) as a novel technology for characterization of nanoparticles. Methods…”
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Surface Energy Determined by Inverse Gas Chromatography as a Tool to Investigate Particulate Interactions in Dry Powder Inhalers by Das, Shyamal C, Tucker, Ian G, Stewart, Peter J

“…Dry powder inhalers (DPIs) usually contain drug particles <6 µm which agglomerate and/ or adhere on the surfaces of large carriers particles. The detachment of…”
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In vitro Dissolution Testing of Rifampicin Powder Formulations For Prediction of Plasma Concentration–Time Profiles After Inhaled Delivery by Khadka, Prakash, Tucker, Ian G., Das, Shyamal C.

“…Purpose The purpose of this study was to evaluate the in vitro lung dissolution of amorphous and crystalline powder formulations of rifampicin in polyethylene…”
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In vitro dissolution testing of respirable size anti-tubercular drug particles using a small volume dissolution apparatus by Eedara, Basanth Babu, Tucker, Ian G., Das, Shyamal C.

“…[Display omitted] A dissolution apparatus that uses a small volume of stationary medium (25 μL) has been developed for in vitro dissolution testing of…”
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Simultaneous determination of methotrexate and its polyglutamate metabolites in Caco-2 cells by liquid chromatography–tandem mass spectrometry by Chen, Gong, Fawcett, J. Paul, Mikov, Momir, Tucker, Ian G.

“…In normal and malignant human cells, the folate antagonist methotrexate (MTX) is converted to a series of polyglutamates (MTXGlu n , n = 2–5) which play a role…”
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Phospholipid-based pyrazinamide spray-dried inhalable powders for treating tuberculosis by Eedara, Basanth Babu, Tucker, Ian G., Das, Shyamal C.

“…[Display omitted] Sterilization of necrotic granulomas containing Mycobacterium tuberculosis is difficult by oral and parenteral drug delivery of…”
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Preparation of biodegradable insulin nanocapsules from biocompatible microemulsions by WATNASIRICHAIKUL, S, DAVIES, N. M, RADES, T, TUCKER, I. G

“…To prepare poly(ethyl 2-cyanoacrylate) nanocapsules containing insulin by interfacial polymerization of spontaneously forming, biocompatible microemulsions. A…”
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High dose dry powder inhalers to overcome the challenges of tuberculosis treatment by Momin, Mohammad A.M., Tucker, Ian G., Das, Shyamal C.

“…[Display omitted] Tuberculosis (TB) is a major global health burden. The emergence of the human immunodeficiency virus (HIV) epidemic and drug resistance has…”
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Dry powder formulation of kanamycin with enhanced aerosolization efficiency for drug-resistant tuberculosis by Momin, Mohammad A.M., Sinha, Shubhra, Tucker, Ian G., Doyle, Colin, Das, Shyamal C.

“…[Display omitted] Kanamycin, an injectable agent, is currently used to treat drug-resistant tuberculosis (TB). Parenteral kanamycin causes high systemic…”
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Pharmacokinetics of rifampicin after repeated intra-tracheal administration of amorphous and crystalline powder formulations to Sprague Dawley rats by Khadka, Prakash, Sinha, Shubhra, Tucker, Ian G., Dummer, Jack, Hill, Philip C., Katare, Rajesh, Das, Shyamal C.

“…[Display omitted] Rifampicin is one of the key drugs used to treat tuberculosis and is currently used orally. The use of higher oral doses of rifampicin is…”
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A STELLA simulation model for in vitro dissolution testing of respirable size particles by Eedara, Basanth Babu, Tucker, Ian G., Das, Shyamal C.

“…In vitro dissolution testing is a useful quality control tool to discriminate the formulations and to approximate the in vivo drug release profiles. A…”
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Studies on the safety and the tissue distribution of inhaled high-dose amorphous and crystalline rifampicin in a rat model by Khadka, Prakash, Sinha, Shubhra, Tucker, Ian G., Dummer, Jack, Hill, Philip C., Katare, Rajesh, Das, Shyamal C.

“…[Display omitted] Inhaled delivery of rifampicin has the potential to achieve high drug concentrations in the lung and the blood for efficient treatment of…”
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Cell‐based, animal and H1 receptor binding studies relative to the sedative effects of ketotifen and norketotifen atropisomers by Feng, Feifei, Fawcett, J. Paul, Zhang, Hu, Tucker, Ian G.

“…Objectives Ketotifen (K) and its active metabolite norketotifen (N) exist as optically active atropisomers. They both have antihistaminic and anti‐inflammatory…”
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Oral Delivery of Mycobacterium bovis BCG in a Lipid Formulation Induces Resistance to Pulmonary Tuberculosis in Mice by ALDWELL, Frank E, TUCKER, Ian G, DE LISLE, Geoffrey W, BUDDLE, Bryce M

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Co-spray drying of hygroscopic kanamycin with the hydrophobic drug rifampicin to improve the aerosolization of kanamycin powder for treating respiratory infections by Momin, Mohammad A.M., Tucker, Ian G., Doyle, Colin S., Denman, John A., Sinha, Shubhra, Das, Shyamal C.

“…[Display omitted] High dose delivery of drugs to the lung using a dry powder inhaler (DPI) is an emerging approach to combat drug-resistant local infections…”
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Manipulation of spray-drying conditions to develop dry powder particles with surfaces enriched in hydrophobic material to achieve high aerosolization of a hygroscopic drug by Momin, Mohammad A.M., Tucker, Ian G., Doyle, Colin S., Denman, John A., Das, Shyamal C.

“…[Display omitted] This study aimed to develop dry powder particles with surfaces enriched in hydrophobic material by manipulation of spray-drying conditions…”
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The Population Pharmacokinetics of d-β-hydroxybutyrate Following Administration of (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate by Shivva, Vittal, Cox, Pete J., Clarke, Kieran, Veech, Richard L., Tucker, Ian G., Duffull, Stephen B.

“…The administration of ketones to induce a mild ketosis is of interest for the alleviation of symptoms associated with various neurological disorders. This…”
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