Search Results - "Tucker, Geoffrey T"

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data by Rostami-Hodjegan, Amin, Tucker, Geoffrey T

“…The perceived failure of new drug development has been blamed on deficiencies in in vivo studies of drug efficacy and safety. Prior simulation of the potential…”
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A Re-evaluation and Validation of Ontogeny Functions for Cytochrome P450 1A2 and 3A4 Based on In Vivo Data by Salem, Farzaneh, Johnson, Trevor N., Abduljalil, Khaled, Tucker, Geoffrey T., Rostami-Hodjegan, Amin

“…Background and Objectives Current cytochrome P450 (CYP) 1A2 and 3A4 ontogeny profiles, which are derived mainly from in vitro studies and incorporated in…”
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Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children by JOHNSON, Trevor N, ROSTAMI-HODJEGAN, Amin, TUCKER, Geoffrey T

“…Prediction of the exposure of neonates, infants and children to xenobiotics is likely to be more successful using physiologically based pharmacokinetic models…”
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Does age affect gastric emptying time? A model-based meta-analysis of data from premature neonates through to adults by Bonner, Jennifer J., Vajjah, Pavan, Abduljalil, Khaled, Jamei, Masoud, Rostami-Hodjegan, Amin, Tucker, Geoffrey T., Johnson, Trevor N.

“…Purpose. Gastric emptying (GE) is often reported to be slower and more irregular in premature neonates than in older children and adults. The aim of this study…”
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A Semi-Mechanistic Model to Predict the Effects of Liver Cirrhosis on Drug Clearance by Johnson, Trevor N., Boussery, Koen, Rowland-Yeo, Karen, Tucker, Geoffrey T., Rostami-Hodjegan, Amin

“…Background and Objective: Liver cirrhosis is characterized by a decrease in functional hepatocytes, lowered circulating levels of plasma proteins and…”
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In Vitro Characterization of the Human Liver Microsomal Kinetics and Reaction Phenotyping of Olanzapine Metabolism by Korprasertthaworn, Porntipa, Polasek, Thomas M, Sorich, Michael J, McLachlan, Andrew J, Miners, John O, Tucker, Geoffrey T, Rowland, Andrew

“…Olanzapine (OLZ) is an atypical antipsychotic used in the treatment of schizophrenia and related psychoses. The metabolism of OLZ is complex and incompletely…”
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Assessment of algorithms for predicting drug–drug interactions via inhibition mechanisms: comparison of dynamic and static models by Guest, Eleanor J., Rowland‐Yeo, Karen, Rostami‐Hodjegan, Amin, Tucker, Geoffrey T., Houston, J. Brian, Galetin, Aleksandra

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • The prediction of drug–drug interactions (DDIs) from in vitro data usually utilizes an average dosing interval…”
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Personalized Drug Dosage – Closing the Loop by Tucker, Geoffrey T

“…A brief account is given of various approaches to the individualization of drug dosage, including the use of pharmacodynamic markers, therapeutic monitoring of…”
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Erratum to: A Re-evaluation and Validation of Ontogeny Functions for Cytochrome P450 1A2 and 3A4 Based on In Vivo Data by Salem, Farzaneh, Johnson, Trevor N., Abduljalil, Khaled, Tucker, Geoffrey T., Rostami-Hodjegan, Amin

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Differences in Cytochrome P450-Mediated Pharmacokinetics Between Chinese and Caucasian Populations Predicted by Mechanistic Physiologically Based Pharmacokinetic Modelling by Barter, Zoe E., Tucker, Geoffrey T., Rowland-Yeo, Karen

“…Background International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) guidelines emphasize the…”
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Was 4β‐hydroxycholesterol ever going to be a useful marker of CYP3A4 activity? by Neuhoff, Sibylle, Tucker, Geoffrey T.

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Letter to the editor about reporting drug concentrations and pharmacokinetics in regional anesthesia and pain medicine by Mather, Laurence E, Tucker, Geoffrey T

“…Whereas arterial blood drug concentrations, other than those in pulmonary vessels, will be essentially the same throughout the body, those in veins differ,…”
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When Regional Anesthesia Met Pharmacokinetics by Mather, Laurence E., Tucker, Geoffrey T.

“…Pharmacokinetics of Local Anaesthetic Agents. By Tucker GT, Mather LE. Br J Anaesth 1975; 47(suppl 1):213–24 Information derived from measurements of blood…”
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Implications of mechanism-based inhibition of CYP2D6 for the pharmacokinetics and toxicity of MDMA by Yang, Jiansong, Jamei, Masoud, Heydari, Amir, Yeo, Karen R., de la Torre, Rafael, Farré, Magí, Tucker, Geoffrey T., Rostami-Hodjegan, Amin

“…The aim of this study was to model the in vivo kinetic consequences of mechanism-based inhibition (MBI) of CYP2D6 by 3,4 methylenedioxymethamphetamine (MDMA,…”
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Metformin disposition—A 40‐year‐old mystery by Tucker, Geoffrey T., Wesolowski, Carl A.

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Inhibition of human UDP-glucuronosyltransferase enzymes by lapatinib, pazopanib, regorafenib and sorafenib: Implications for hyperbilirubinemia by Miners, John O., Chau, Nuy, Rowland, Andrew, Burns, Kushari, McKinnon, Ross A., Mackenzie, Peter I., Tucker, Geoffrey T., Knights, Kathleen M., Kichenadasse, Ganessan

“…[Display omitted] Kinase inhibitors (KIs) are a rapidly expanding class of drugs used primarily for the treatment of cancer. Data relating to the inhibition of…”
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Comment on: “The pharmacokinetics of metformin in patients receiving intermittent haemodialysis” by Sinnappah et al by Tucker, Geoffrey T., Wesolowski, Carl A.

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The British Journal of Clinical Pharmacology: The first 50 years by Cremers, Serge, Tucker, Geoffrey T., Aronson, Jeffrey K., Ritter, James M., Cohen, Adam F.

“…The British Journal of Clinical Pharmacology celebrates its 50th anniversary of publication in 2023. Here four previous Editors‐in‐Chief and the current Editor…”
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Prediction of olanzapine exposure in individual patients using physiologically based pharmacokinetic modelling and simulation by Polasek, Thomas M., Tucker, Geoffrey T., Sorich, Michael J., Wiese, Michael D., Mohan, Titus, Rostami‐Hodjegan, Amin, Korprasertthaworn, Porntipa, Perera, Vidya, Rowland, Andrew

“…Aim The aim of the present study was to predict olanzapine (OLZ) exposure in individual patients using physiologically based pharmacokinetic modelling and…”
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A series acceleration algorithm for the gamma-Pareto (type I) convolution and related functions of interest for pharmacokinetics by Wesolowski, Carl A., Alcorn, Jane, Tucker, Geoffrey T.

“…The gamma-Pareto type I convolution (GPC type I) distribution, which has a power function tail, was recently shown to describe the disposition kinetics of…”
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