Search Results - "Tuck, Alan B"

G protein-coupled KISS1 receptor is overexpressed in triple negative breast cancer and promotes drug resistance by Blake, Alexandra, Dragan, Magdalena, Tirona, Rommel G., Hardy, Daniel B., Brackstone, Muriel, Tuck, Alan B., Babwah, Andy V., Bhattacharya, Moshmi

“…Triple-negative breast cancer (TNBC) lacks the expression of estrogen receptor α, progesterone receptor and human epidermal growth factor receptor 2 (HER2)…”
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Osteopontin overexpression in breast cancer: Knowledge gained and possible implications for clinical management by Tuck, Alan B., Chambers, Ann F., Allan, Alison L.

“…Osteopontin (OPN) is a secreted protein that is overexpressed in a number of human cancers, and has been associated with increased metastatic burden and poor…”
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Pre- and post-translational regulation of osteopontin in cancer by Anborgh, Pieter H., Mutrie, Jennifer C., Tuck, Alan B., Chambers, Ann F.

“…Osteopontin (OPN) is a matricellular protein that binds to a number of cell surface receptors including integrins and CD44. It is expressed in many tissues and…”
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G protein-coupled kisspeptin receptor induces metabolic reprograming and tumorigenesis in estrogen receptor-negative breast cancer by Dragan, Magdalena, Nguyen, Mai-Uyen, Guzman, Stephania, Goertzen, Cameron, Brackstone, Muriel, Dhillo, Waljit S., Bech, Paul R., Clarke, Sophie, Abbara, Ali, Tuck, Alan B., Hess, David A., Pine, Sharon R., Zong, Wei-Xing, Wondisford, Frederic E., Su, Xiaoyang, Babwah, Andy V., Bhattacharya, Moshmi

“…Triple-negative breast cancer (TNBC) is a highly metastatic and deadly disease. TNBC tumors lack estrogen receptor (ERα), progesterone receptor (PR), and HER2…”
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Serial Plasma Osteopontin Levels Have Prognostic Value in Metastatic Breast Cancer by BRAMWELL, Vivien H. C, DOIG, Gordon S, TUCK, Alan B, WILSON, Sylvia M, TONKIN, Katia S, TOMIAK, Anna, PERERA, Francisco, VANDENBERG, Theodore A, CHAMBERS, Ann F

“…Purpose: Osteopontin is a malignancy-associated protein measurable in blood and tumor tissue. To evaluate its prognostic value in advanced disease, we…”
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Genome-wide analysis reveals a role for TDG in estrogen receptor-mediated enhancer RNA transcription and 3-dimensional reorganization by Kolendowski, Bart, Hassan, Haider, Krstic, Milica, Isovic, Majdina, Thillainadesan, Gobi, Chambers, Ann F, Tuck, Alan B, Torchia, Joseph

“…The estrogen receptor (ER) is a ligand-dependant transcription factor expressed in many breast cancers and is the target of many endocrine-based cancer…”
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Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis by Goulet, Brigitte, Kennette, Wendy, Ablack, Amber, Postenka, Carl O, Hague, M Nicole, Mymryk, Joe S, Tuck, Alan B, Giguère, Vincent, Chambers, Ann F, Lewis, John D

“…Maspin (mammary serine protease inhibitor or SerpinB5) acts as a tumor suppressor when overexpressed in aggressive cancer cell lines. However, its role in…”
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Multi-platform whole-genome microarray analyses refine the epigenetic signature of breast cancer metastasis with gene expression and copy number by Andrews, Joseph, Kennette, Wendy, Pilon, Jenna, Hodgson, Alexandra, Tuck, Alan B, Chambers, Ann F, Rodenhiser, David I

“…We have previously identified genome-wide DNA methylation changes in a cell line model of breast cancer metastasis. These complex epigenetic changes that we…”
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Tumor dormancy and cancer stem cells: implications for the biology and treatment of breast cancer metastasis by Allan, Alison L, Vantyghem, Sharon A, Tuck, Alan B, Chambers, Ann F

“…Breast cancer remains a leading cause of morbidity and mortality in women, mainly due to the propensity of primary breast tumors to metastasize to regional and…”
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Epigenetic mapping and functional analysis in a breast cancer metastasis model using whole-genome promoter tiling microarrays by Rodenhiser, David I, Andrews, Joseph, Kennette, Wendy, Sadikovic, Bekim, Mendlowitz, Ariel, Tuck, Alan B, Chambers, Ann F

“…Breast cancer metastasis is a complex, multi-step biological process. Genetic mutations along with epigenetic alterations in the form of DNA methylation…”
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The thrombin inhibitor Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and osteopontin-independent mechanisms by Schulze, Erika B., Hedley, Benjamin D., Goodale, David, Postenka, Carl O., Al-Katib, Waleed, Tuck, Alan B., Chambers, Ann F., Allan, Alison L.

“…Osteopontin (OPN) has been clinically and experimentally associated with breast cancer metastasis. Proteolytic cleavage of OPN by thrombin has been reported to…”
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Dietary genistein reduces metastasis in a postsurgical orthotopic breast cancer model by VANTYGHEM, Sharon A, WILSON, Sylvia M, POSTENKA, Carl O, AL-KATIB, Waleed, TUCK, Alan B, CHAMBERS, Ann F

“…Metastatic spread, not primary tumor burden, is the leading cause of breast cancer deaths. For patient prognosis to improve, new systemic adjuvant therapies…”
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Osteopontin Induction of Hyaluronan Synthase 2 Expression Promotes Breast Cancer Malignancy by Cook, Amy C., Chambers, Ann F., Turley, Eva A., Tuck, Alan B.

“…Osteopontin (OPN) is a tumor-associated, secreted phosphoprotein that has been implicated in breast cancer progression and metastasis. Research concerning how…”
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Enhanced cell surface CD44 variant (v6, v9) expression by osteopontin in breast cancer epithelial cells facilitates tumor cell migration: novel post-transcriptional, post-translational regulation by Khan, Subarna A, Cook, Amy C, Kappil, Maya, Günthert, Ursula, Chambers, Ann F, Tuck, Alan B, Denhardt, David T

“…Osteopontin (OPN) is a glycosylated, secreted phosphoprotein that functions both as a cell attachment and chemotactic factor. Elevated expression of OPN…”
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Osteopontin increases breast cancer cell sensitivity to specific signaling pathway inhibitors in preclinical models by Mutrie, Jennifer C., Chambers, Ann F., Tuck, Alan B.

“…Src kinase and Hsp90 play important roles in malignancy-promoting signaling pathways in a variety of cancers and related targeting agents are presently in…”
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Changes over time of extracellular domain of HER2 (ECD/HER2) serum levels have prognostic value in metastatic breast cancer by Bramwell, Vivien H. C, Doig, Gordon S, Tuck, Alan B, Wilson, Sylvia M, Tonkin, Katia S, Tomiak, Anna, Perera, Francisco, Vandenberg, Theodore A, Chambers, Ann F

“…Background Blood levels of the extracellular domain of HER-2/neu (ECD/HER2) have been suggested to have potential as a tumor marker in breast cancer. Our aim…”
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The role of osteopontin in breast cancer: clinical and experimental studies by Tuck, A B, Chambers, A F

“…Osteopontin (OPN) is a secreted, integrin-binding protein which has been implicated in cancer, as well as other pathologies and some aspects of normal…”
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Concurrent Neoadjuvant Chemotherapy and Radiation Therapy in Locally Advanced Breast Cancer by Brackstone, Muriel, Palma, David, Tuck, Alan B., Scott, Leslie, Potvin, Kylea, Vandenberg, Theodore, Perera, Francisco, D'Souza, David, Taves, Donald, Kornecki, Anat, Muscedere, Giulio, Chambers, Ann F.

“…To evaluate whether concurrent neoadjuvant radiation added to standard chemotherapy could increase the pathologic complete response (pCR) to treatment for…”
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Detection and quantification of circulating tumor cells in mouse models of human breast cancer using immunomagnetic enrichment and multiparameter flow cytometry by Allan, Alison L., Vantyghem, Sharon A., Tuck, Alan B., Chambers, Ann F., Chin‐Yee, Ian H., Keeney, Michael

“…Background Circulating tumor cells (CTCs) in the peripheral blood of breast cancer patients may be an important indicator of metastatic disease and poor…”
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Role of the metastasis‐promoting protein osteopontin in the tumour microenvironment by Anborgh, Pieter H., Mutrie, Jennifer C., Tuck, Alan B., Chambers, Ann F.

“…Osteopontin (OPN) is a secreted protein present in bodily fluids and tissues. It is subject to multiple post‐translational modifications, including…”
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