Search Results - "Tuccinardi, Tiziano"

The History of Nanoscience and Nanotechnology: From Chemical-Physical Applications to Nanomedicine by Bayda, Samer, Adeel, Muhammad, Tuccinardi, Tiziano, Cordani, Marco, Rizzolio, Flavio

“…Nanoscience breakthroughs in almost every field of science and nanotechnologies make life easier in this era. Nanoscience and nanotechnology represent an…”
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Application of MM-PBSA Methods in Virtual Screening by Poli, Giulio, Granchi, Carlotta, Rizzolio, Flavio, Tuccinardi, Tiziano

“…Computer-aided drug design techniques are today largely applied in medicinal chemistry. In particular, receptor-based virtual screening (VS) studies, in which…”
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Docking-based virtual screening: recent developments by Tuccinardi, Tiziano

“…Virtual (database) screening (VS) of molecules promises to accelerate the discovery of new drugs and reduce costs by identifying molecules with high…”
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The Benzoylpiperidine Fragment as a Privileged Structure in Medicinal Chemistry: A Comprehensive Review by Bononi, Giulia, Lonzi, Chiara, Tuccinardi, Tiziano, Minutolo, Filippo, Granchi, Carlotta

“…The phenyl(piperidin-4-yl)methanone fragment (here referred to as the benzoylpiperidine fragment) is a privileged structure in the development of new drugs…”
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Recent Advances in In Silico Target Fishing by Galati, Salvatore, Di Stefano, Miriana, Martinelli, Elisa, Poli, Giulio, Tuccinardi, Tiziano

“…In silico target fishing, whose aim is to identify possible protein targets for a query molecule, is an emerging approach used in drug discovery due its wide…”
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Former foodstuff in mealworm farming: Effects on fatty acids profile, lipid metabolism and antioxidant molecules by Mattioli, Simona, Paci, Gisella, Fratini, Filippo, Dal Bosco, Alessandro, Tuccinardi, Tiziano, Mancini, Simone

“…The capability of some insects to be reared on by-products, waste and former foodstuff make them a very promising response to the increasing request of…”
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Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide by Santamaria, Salvatore, Cuffaro, Doretta, Nuti, Elisa, Ciccone, Lidia, Tuccinardi, Tiziano, Liva, Francesca, D’Andrea, Felicia, de Groot, Rens, Rossello, Armando, Ahnström, Josefin

“…ADAMTS-5 is a major protease involved in the turnover of proteoglycans such as aggrecan and versican. Dysregulated aggrecanase activity of ADAMTS-5 has been…”
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Former Foodstuff Products in Tenebrio Molitor Rearing: Effects on Growth, Chemical Composition, Microbiological Load, and Antioxidant Status by Mancini, Simone, Fratini, Filippo, Turchi, Barbara, Mattioli, Simona, Dal Bosco, Alessandro, Tuccinardi, Tiziano, Nozic, Sanjin, Paci, Gisella

“…(mealworm) larvae represent one of the most interesting edible insects and could be reared on alternative feeds, such as former foodstuff products (FFPs). In…”
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VenomPred: A Machine Learning Based Platform for Molecular Toxicity Predictions by Galati, Salvatore, Di Stefano, Miriana, Martinelli, Elisa, Macchia, Marco, Martinelli, Adriano, Poli, Giulio, Tuccinardi, Tiziano

“…The use of in silico toxicity prediction methods plays an important role in the selection of lead compounds and in ADMET studies since in vitro and in vivo…”
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Structural Optimization of 4‑Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors by Granchi, Carlotta, Rizzolio, Flavio, Palazzolo, Stefano, Carmignani, Sara, Macchia, Marco, Saccomanni, Giuseppe, Manera, Clementina, Martinelli, Adriano, Minutolo, Filippo, Tuccinardi, Tiziano

“…Monoacylglycerol lipase (MAGL) inhibitors are considered potential therapeutic agents for a variety of pathological conditions, including several types of…”
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Sirtuin 1-Activating Compounds: Discovery of a Class of Thiazole-Based Derivatives by Bononi, Giulia, Citi, Valentina, Lapillo, Margherita, Martelli, Alma, Poli, Giulio, Tuccinardi, Tiziano, Granchi, Carlotta, Testai, Lara, Calderone, Vincenzo, Minutolo, Filippo

“…Sirtuin 1 (SIRT1) is a NAD+-dependent deacetylase implicated in various biological and pathological processes, including cancer, diabetes, and cardiovascular…”
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Editorial: Peptidyl-Prolyl Isomerases in Human Pathologies by Tuccinardi, Tiziano, Rizzolio, Flavio

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Identification of New GSK3β Inhibitors through a Consensus Machine Learning-Based Virtual Screening by Galati, Salvatore, Di Stefano, Miriana, Bertini, Simone, Granchi, Carlotta, Giordano, Antonio, Gado, Francesca, Macchia, Marco, Tuccinardi, Tiziano, Poli, Giulio

“…Glycogen synthase kinase-3 beta (GSK3β) is a serine/threonine kinase that plays key roles in glycogen metabolism, Wnt/β-catenin signaling cascade, synaptic…”
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Extensive Reliability Evaluation of Docking-Based Target-Fishing Strategies by Lapillo, Margherita, Tuccinardi, Tiziano, Martinelli, Adriano, Macchia, Marco, Giordano, Antonio, Poli, Giulio

“…The development of target-fishing approaches, aimed at identifying the possible protein targets of a small molecule, represents a hot topic in medicinal…”
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The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation by Carpi, Sara, Scoditti, Egeria, Massaro, Marika, Polini, Beatrice, Manera, Clementina, Digiacomo, Maria, Esposito Salsano, Jasmine, Poli, Giulio, Tuccinardi, Tiziano, Doccini, Stefano, Santorelli, Filippo Maria, Carluccio, Maria Annunziata, Macchia, Marco, Wabitsch, Martin, De Caterina, Raffaele, Nieri, Paola

“…Inflammation of the adipose tissue plays an important role in the development of several chronic diseases associated with obesity. Polyphenols of extra virgin…”
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Watermelon: setup and validation of an in silico fragment-based approach by Di Stefano, Miriana, Galati, Salvatore, Piazza, Lisa, Gado, Francesca, Granchi, Carlotta, Macchia, Marco, Giordano, Antonio, Tuccinardi, Tiziano, Poli, Giulio

“…We present a new computational approach, named , designed for the development of pharmacophore models based on receptor structures. The methodology involves…”
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The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives by Nassini, Romina, Fusi, Camilla, Materazzi, Serena, Coppi, Elisabetta, Tuccinardi, Tiziano, Marone, Ilaria M, De Logu, Francesco, Preti, Delia, Tonello, Raquel, Chiarugi, Alberto, Patacchini, Riccardo, Geppetti, Pierangelo, Benemei, Silvia

“…Background and Purpose Although still used by hundreds of millions of people worldwide, the mechanism of the analgesic action of the pyrazolone derivatives…”
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Resveratrol Analogues as Dual Inhibitors of Monoamine Oxidase B and Carbonic Anhydrase VII: A New Multi-Target Combination for Neurodegenerative Diseases? by Carradori, Simone, Fantacuzzi, Marialuigia, Ammazzalorso, Alessandra, Angeli, Andrea, De Filippis, Barbara, Galati, Salvatore, Petzer, Anél, Petzer, Jacobus P, Poli, Giulio, Tuccinardi, Tiziano, Agamennone, Mariangela, Supuran, Claudiu T

“…Neurodegenerative diseases (NDs) are described as multifactorial and progressive syndromes with compromised cognitive and behavioral functions. The…”
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SMS121, a new inhibitor of CD36, impairs fatty acid uptake and viability of acute myeloid leukemia by Åbacka, Hannah, Masoni, Samuele, Poli, Giulio, Huang, Peng, Gusso, Francesco, Granchi, Carlotta, Minutolo, Filippo, Tuccinardi, Tiziano, Hagström-Andersson, Anna K., Lindkvist-Petersson, Karin

“…Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the second most common among children. AML is characterized by aberrant…”
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An in silico toolbox for the prediction of the potential pathogenic effects of missense mutations in the dimeric region of hRPE65 by Poli, Giulio, Demontis, Gian Carlo, Sodi, Andrea, Saba, Alessandro, Rizzo, Stanislao, Macchia, Marco, Tuccinardi, Tiziano

“…hRPE65 is a fundamental enzyme of the retinoid visual cycle, and many missense mutations affecting its expression or function are associated with a wide range…”
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