Search Results - "Tubbs, Justin"

Preliminary Evidence for Genetic Nurture in Depression and Neuroticism Through Polygenic Scores by Tubbs, Justin D, Sham, Pak C

“…Modeling genetic nurture (ie, the effects of parental genotypes through influences on the environment experienced by their children) is essential to accurately…”
Get more information

Estimating indirect parental genetic effects on offspring phenotypes using virtual parental genotypes derived from sibling and half sibling pairs by Hwang, Liang-Dar, Tubbs, Justin D, Luong, Justin, Lundberg, Mischa, Moen, Gunn-Helen, Wang, Geng, Warrington, Nicole M, Sham, Pak C, Cuellar-Partida, Gabriel, Evans, David M

“…Indirect parental genetic effects may be defined as the influence of parental genotypes on offspring phenotypes over and above that which results from the…”
Get full text

Extended gene set analysis of human neuro-psychiatric traits shows enrichment in brain-expressed human accelerated regions across development by Cheung, Justin P., Tubbs, Justin D., Sham, Pak C.

“…Human neuropsychiatric disorders are associated with genetic and environmental factors affecting the brain, which has been subjected to strong evolutionary…”
Get full text

Mendelian randomization: causal inference leveraging genetic data by Chen, Lane G, Tubbs, Justin D, Liu, Zipeng, Thach, Thuan-Quoc, Sham, Pak C

“…Mendelian randomization (MR) leverages genetic information to examine the causal relationship between phenotypes allowing for the presence of unmeasured…”
Get more information

Reciprocal causation mixture model for robust Mendelian randomization analysis using genome-scale summary data by Liu, Zipeng, Qin, Yiming, Wu, Tian, Tubbs, Justin D., Baum, Larry, Mak, Timothy Shin Heng, Li, Miaoxin, Zhang, Yan Dora, Sham, Pak Chung

“…Mendelian randomization using GWAS summary statistics has become a popular method to infer causal relationships across complex diseases. However, the…”
Get full text

Systemic neuro-dysregulation in depression: Evidence from genome-wide association by Tubbs, Justin D., Ding, Jiahong, Baum, Larry, Sham, Pak C.

“…Depression is the world's leading cause of disability. Greater understanding of the neurobiological basis of depression is necessary for developing novel…”
Get full text

Genome-wide DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia in the Chinese Han population by Li, Mingrui, Li, Yanli, Qin, Haide, Tubbs, Justin D., Li, Minghui, Qiao, Chunhong, Lin, Jinran, Li, Qingyang, Fan, Fengmei, Gou, Mengzhuang, Huang, Junchao, Tong, Jinghui, Yang, Fude, Tan, Yunlong, Yao, Yin

“…Schizophrenia is a severe neuropsychiatric disorder with core features including hallucinations, delusions, and cognition deficits. Accumulating evidence has…”
Get full text

Intermediate confounding in trio relationships: The importance of complete data in effect size estimation by Tubbs, Justin D., Zhang, Yan D., Sham, Pak C.

“…We present an important characteristic of trio models which may lead to bias and loss of power when one parent is unmodeled in trio analyses. Motivated by…”
Get full text

Association of neurotransmitter pathway polygenic risk with specific symptom profiles in psychosis by Warren, Tracy L., Tubbs, Justin D., Lesh, Tyler A., Corona, Mylena B., Pakzad, Sarvenaz S., Albuquerque, Marina D., Singh, Praveena, Zarubin, Vanessa, Morse, Sarah J., Sham, Pak Chung, Carter, Cameron S., Nord, Alex S.

“…A primary goal of psychiatry is to better understand the pathways that link genetic risk to psychiatric symptoms. Here, we tested association of diagnosis and…”
Get full text

The Genes We Inherit and Those We Don’t: Maternal Genetic Nurture and Child BMI Trajectories by Tubbs, Justin D., Porsch, Robert M., Cherny, Stacey S., Sham, Pak C.

“…Recently, methods have been introduced using polygenic scores (PGS) to estimate the effects of genetic nurture, the environmentally-mediated effects of…”
Get full text

Bidirectional two-sample Mendelian randomization study of differential white blood cell counts and schizophrenia by Leung, Perry B.M., Liu, Zipeng, Zhong, Yuanxin, Tubbs, Justin D., Di Forti, Marta, Murray, Robin M., So, Hon-Cheong, Sham, Pak C., Lui, Simon S.Y.

“…•Multiple mendelian randomization (MR) methods examined the directions of genetically-predicted relationships between schizophrenia and white cell…”
Get full text

Improved nonparametric penalized maximum likelihood estimation for arbitrarily censored survival data by Tubbs, Justin D., Chen, Lane G., Thach, Thuan‐Quoc, Sham, Pak C.

“…Nonparametric maximum likelihood estimation encompasses a group of classic methods to estimate distribution‐associated functions from potentially censored and…”
Get full text

Short-Term Training in Mindfulness Predicts Helping Behavior Toward Racial Ingroup and Outgroup Members by Berry, Daniel R., Wall, Catherine S. J., Tubbs, Justin D., Zeidan, Fadel, Brown, Kirk Warren

“…A randomized controlled trial tested whether mindfulness training would increase lab-based and in vivo spontaneous helping behaviors toward racial outgroup…”
Get full text

Immune dysregulation in depression: Evidence from genome-wide association by Tubbs, Justin D., Ding, Jiahong, Baum, Larry, Sham, Pak C.

“…A strong body of evidence supports a role for immune dysregulation across many psychiatric disorders including depression, the leading cause of global…”
Get full text

Correction: Genome-wide DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia in the Chinese Han population by Li, Mingrui, Li, Yanli, Qin, Haide, Tubbs, Justin D., Li, Minghui, Qiao, Chunhong, Lin, Jinran, Li, Qingyang, Fan, Fengmei, Gou, Mengzhuang, Huang, Junchao, Tong, Jinghui, Yang, Fude, Tan, Yunlong, Yao, Yin

“…A Correction to this paper has been published: https://doi.org/10.1038/s41380-020-01013-w…”
Get full text

Mindfulness moderates the relation between trauma and anxiety symptoms in college students by Tubbs, Justin D., Savage, Jeanne E., Adkins, Amy E., Amstadter, Ananda B., Dick, Danielle M.

“…Objective: To explore the relations between trauma exposure and anxiety and depression among college students, and to determine whether trait mindfulness may…”
Get full text

Modeling Parent-Specific Genetic Nurture in Families with Missing Parental Genotypes: Application to Birthweight and BMI by Tubbs, Justin D., Hwang, Liang-Dar, Luong, Justin, Evans, David M., Sham, Pak C.

“…Disaggregation and estimation of genetic effects from offspring and parents has long been of interest to statistical geneticists. Recently, technical and…”
Get full text

Innocuous pressure sensation requires A-type afferents but not functional ΡΙΕΖΟ2 channels in humans by Case, Laura K., Liljencrantz, Jaquette, Madian, Nicholas, Necaise, Aaron, Tubbs, Justin, McCall, Micaela, Bradson, Megan L., Szczot, Marcin, Pitcher, Mark H., Ghitani, Nima, Frangos, Eleni, Cole, Jonathan, Bharucha-Goebel, Diana, Saade, Dimah, Ogata, Tracy, Donkervoort, Sandra, Foley, A. Reghan, Bönnemann, Carsten G., Olausson, Håkan, Bushnell, M. Catherine, Chesler, Alexander T.

“…The sensation of pressure allows us to feel sustained compression and body strain. While our understanding of cutaneous touch has grown significantly in recent…”
Get full text

Third-generation genome sequencing implicates medium-sized structural variants in chronic schizophrenia by Lee, Chi Chiu, Ye, Rui, Tubbs, Justin D, Baum, Larry, Zhong, Yuanxin, Leung, Shuk Yan Joey, Chan, Sheung Chun, Wu, Kit Ying Kitty, Cheng, Po Kwan Jamie, Chow, Lai Ping, Leung, Patrick W L, Sham, Pak Chung

“…Schizophrenia (SCZ) is a heterogeneous psychiatric disorder, with significant contribution from genetic factors particularly for chronic cases with negative…”
Get full text

Whole-exome sequencing in a Chinese sample provides preliminary evidence for the link between rare/low-frequency immune-related variants and early-onset schizophrenia by Zhong, Yuanxin, Tubbs, Justin D., Leung, Perry B.M., Zhan, Na, Hui, Tomy C.K., Ho, Karen K.Y., Hung, Karen S.Y., Cheung, Eric F.C., So, Hon-Cheong, Lui, Simon S.Y., Sham, Pak C.

“…Rare and low-frequency variants contribute to schizophrenia (SCZ), and may influence its age-at-onset (AAO). We examined the association of rare or…”
Get full text