Search Results - "Tubbesing, Kate"

Comparative phase imaging of live cells by digital holographic microscopy and transport of intensity equation methods by Wittkopp, Jeremy M, Khoo, Ting Chean, Carney, Shane, Pisila, Kai, Bahreini, Shahab J, Tubbesing, Kate, Mahajan, Supriya, Sharikova, Anna, Petruccelli, Jonathan C, Khmaladze, Alexander

“…We describe a microscopic setup implementing phase imaging by digital holographic microscopy (DHM) and transport of intensity equation (TIE) methods, which…”
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Raman microspectroscopy fingerprinting of organoid differentiation state by Tubbesing, Kate, Moskwa, Nicholas, Khoo, Ting Chean, Nelson, Deirdre A., Sharikova, Anna, Feng, Yunlong, Larsen, Melinda, Khmaladze, Alexander

“…Abstract Background Organoids, which are organs grown in a dish from stem or progenitor cells, model the structure and function of organs and can be used to…”
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Quantitative label-free imaging of iron-bound transferrin in breast cancer cells and tumors by Khoo, Ting Chean, Tubbesing, Kate, Rudkouskaya, Alena, Rajoria, Shilpi, Sharikova, Anna, Barroso, Margarida, Khmaladze, Alexander

“…Transferrin (Tf) is an essential serum protein which delivers iron throughout the body via transferrin-receptor (TfR)-mediated uptake and iron release in early…”
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Label‐free subcellular mapping of iron‐bound proteins in breast cancer cells by Tubbesing, Kate, Khoo, Ting, Mandal, Pampa, Khmaladze, Alexander, Barroso, Margarida

“…Dysregulation of iron transport, storage and utilization is at the basis of a variety of human diseases, since free iron can participate in redox reactions…”
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Quantitative imaging of receptor-ligand engagement in intact live animals by Rudkouskaya, Alena, Sinsuebphon, Nattawut, Ward, Jamie, Tubbesing, Kate, Intes, Xavier, Barroso, Margarida

“…Maintaining an intact tumor environment is critical for quantitation of receptor-ligand engagement in a targeted drug development pipeline. However, measuring…”
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Investigation of IL1RAP in vascular endothelial and microglia interactions by Fisher, Elizabeth S, Tubbesing, Kate, Bertucci, Taylor, Stevens, Katherine, TCW, Julia, Goate, Alison, Temple, Sally

“…Background Approximately 84% of Alzheimer’s Disease (AD) patients have cerebrovascular pathology. It remains unclear if vascular damage is causative or a…”
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A Rab4‐Regulated Endosomal Compartment Prolongs EGFR Activation in Breast Cancer Cells by Tubbesing, Kate Elizabeth, Ward, Jamie, Rudkouskaya, Alena, Barroso, Margarida

“…Early sorting endosomes are responsible for the proper trafficking of membrane‐bound receptors that can drive cancer progression. However, the morphology,…”
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Iron-binding cellular profile of transferrin using label-free Raman hyperspectral imaging and singular value decomposition (SVD) by Tubbesing, Kate, Khoo, Ting Chean, Bahreini Jangjoo, Shahab, Sharikova, Anna, Barroso, Margarida, Khmaladze, Alexander

“…Serum transferrin (Tf) is the essential iron transport protein in the body. Transferrin is responsible for the sequestration of free iron in serum and the…”
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Complex Rab4-Mediated Regulation of Endosomal Size and EGFR Activation by Tubbesing, Kate, Ward, Jamie, Abini-Agbomson, Raymond, Malhotra, Aditi, Rudkouskaya, Alena, Warren, Janine, Lamar, John, Martino, Nina, Adam, Alejandro P, Barroso, Margarida

“…Early sorting endosomes are responsible for the trafficking and function of transferrin receptor (TfR) and EGFR. These receptors play important roles in iron…”
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Enlarged endosomes and altered transferrin recycling in breast cancer cells by Tubbesing, Kate Elizabeth, Malhotra, Aditi, Rudkouskaya, Alena, Barroso, Margarida

“…Abstract only Understanding how the endocytic pathway is regulated in different types of cancer cells remains a critical biological question with far reaching…”
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Heterogeneity of Transferrin receptor expression, distribution and transferrin uptake in breast cancer cells in 2D and 3D spheroid cultures by Barroso, Margarida M, Ward, Jamie, Wang, Ling, Tubbesing, Kate, Rudkouskaya, Alena, Kingsley, David, Corr, David

“…Alterations in the expression of proteins involved in iron homeostasis have been detected in cancer cells, and their levels appear to correlate inversely with…”
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Mitochondrial Dynamics in SARS-COV2 Spike Protein Treated Human Microglia: Implications for Neuro-COVID by Clough, Erin, Inigo, Joseph, Chandra, Dhyan, Chaves, Lee, Reynolds, Jessica L., Aalinkeel, Ravikumar, Schwartz, Stanley A., Khmaladze, Alexander, Mahajan, Supriya D.

“…Emerging clinical data from the current COVID-19 pandemic suggests that ~ 40% of COVID-19 patients develop neurological symptoms attributed to viral…”
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Phosphorylation of GMFγ by c-Abl Coordinates Lamellipodial and Focal Adhesion Dynamics to Regulate Airway Smooth Muscle Cell Migration by Gerlach, Brennan D, Tubbesing, Kate, Liao, Guoning, Rezey, Alyssa C, Wang, Ruping, Barroso, Margarida, Tang, Dale D

“…Airway smooth muscle cells require coordinated protrusion and focal adhesion dynamics to migrate properly. However, the signaling cascades that connect these…”
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Inside-out and Outside-in Regulation: How Transferrin Iron-release and Rab4-GTPases Influence Early Endosome Dynamics by Tubbesing, Kate E

“…Early endosomes (EE) are dynamic compartments, where newly endocytosed receptors take residence prior to either endocytic recycling or trafficking to a…”
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