Search Results - "Tuazon, Julian"

Humble beginnings with big goals: Small molecule soluble epoxide hydrolase inhibitors for treating CNS disorders by Zarriello, Sydney, Tuazon, Julian P, Corey, Sydney, Schimmel, Samantha, Rajani, Mira, Gorsky, Anna, Incontri, Diego, Hammock, Bruce D, Borlongan, Cesar V

“…Soluble epoxide hydrolase (sEH) degrades epoxides of fatty acids including epoxyeicosatrienoic acid isomers (EETs), which are produced as metabolites of the…”
Get full text

MicroRNA-133a and Myocardial Infarction by Xiao, Yi, Zhao, Jiling, Tuazon, Julian P., Borlongan, Cesar V., Yu, Guolong

“…Myocardial infarction (MI) is the leading cause of morbidity and mortality in the world. The infarcted heart displays typical cell death cascades characterized…”
Get full text

Drug-like delivery methods of stem cells as biologics for stroke by Tuazon, Julian P, Castelli, Vanessa, Borlongan, Cesar V

“…: Stem cell therapy is an experimental treatment for brain disorders. Although a cellular product, stem cells can be classified as biologics based on the…”
Get more information

Pituitary Adenylate Cyclase Activating Polypeptide Elicits Neuroprotection Against Acute Ischemic Neuronal Cell Death Associated with NMDA Receptors by Kaneko, Yuji, Tuazon, Julian P., Ji, Xunming, Borlongan, Cesario V.

“…Background/Aims: The endogenous neurotrophic peptides pituitary adenylate cyclase-activating polypeptides (PACAP-27/38) protect against stroke, but the…”
Get full text

Beyond contraception and hormone replacement therapy: Advancing Nestorone to a neuroprotective drug in the clinic by Tuazon, Julian P., Sitruk-Ware, Regine, Borlongan, Cesario V.

“…Neurological diseases such as ischemic stroke can be debilitating and have limited treatments available. The progestin Nestorone® (segesterone acetate) has…”
Get full text

Human stem cells transplanted into the rat stroke brain migrate to the spleen via lymphatic and inflammation pathways by Xu, Kaya, Lee, Jea-Young, Kaneko, Yuji, Tuazon, Julian P, Vale, Fernando, van Loveren, Harry, Borlongan, Cesario V

“…Despite mounting evidence of a massive peripheral inflammatory response accompanying stroke, the ability of intracerebrally transplanted cells to migrate to…”
Get full text

Neuroprotective effects of human bone marrow mesenchymal stem cells against cerebral ischemia are mediated in part by an anti-apoptotic mechanism by Zhang, Yuyang, Yu, Seongjin, Tuazon, Julian, Lee, Jea-Young, Corey, Sydney, Kvederis, Lauren, Kingsbury, Chase, Kaneko, Yuji, Borlongan, Cesar

“…Transplantation of human bone marrow mesenchymal stem cells (hMSCs) stands as a potent stroke therapy, but its exact mechanism remains unknown. This study…”
Get full text

Reprint of: Beyond contraception and hormone replacement therapy: Advancing Nestorone to a neuroprotective drug in the clinic by Tuazon, Julian P., Sitruk-Ware, Regine, Borlongan, Cesario V.

“…Neurological diseases such as ischemic stroke can be debilitating and have limited treatments available. The progestin Nestorone® (segesterone acetate) has…”
Get full text

A Short Bout of Exercise Prior to Stroke Improves Functional Outcomes by Enhancing Angiogenesis by Pianta, Stefano, Lee, Jea Young, Tuazon, Julian P., Castelli, Vanessa, Mantohac, Leigh Monica, Tajiri, Naoki, Borlongan, Cesar V.

“…Stroke remains a significant unmet clinical need with limited therapeutic options. The peculiar feature of ischemic stroke is the interruption in brain…”
Get full text

Gutting the brain of inflammation: A key role of gut microbiome in human umbilical cord blood plasma therapy in Parkinson's disease model by Lee, Jea‐Young, Tuazon, Julian P., Ehrhart, Jared, Sanberg, Paul R., Borlongan, Cesario V.

“…Current therapies for Parkinson's disease (PD), including L‐3,4‐dihydroxyphenylalanine (L‐DOPA), and clinical trials investigating dopaminergic cell…”
Get full text

Empathy in stroke rats is modulated by social settings by Shinozuka, Kazutaka, Tajiri, Naoki, Ishikawa, Hiroto, Tuazon, Julian P, Lee, Jea-Young, Sanberg, Paul R, Zarriello, Sydney, Corey, Sydney, Kaneko, Yuji, Borlongan, Cesario V

“…Rodents display “empathy” defined as perceived physical pain or psychological stress by cagemates when co-experiencing socially distinct traumatic events. The…”
Get full text

Rhynchophylline promotes stem cell autonomous metabolic homeostasis by Kaneko, Yuji, Coats, Alexandreya B., Tuazon, Julian P., Jo, Michiko, Borlongan, Cesar V.

“…Rhynchophylline (Rhy) effectively obstructs the expansive signaling pathways of degenerative diseases, including Alzheimer disease, Parkinson disease, epilepsy…”
Get full text

Understanding the Role of Dysfunctional and Healthy Mitochondria in Stroke Pathology and Its Treatment by Nguyen, Hung, Zarriello, Sydney, Rajani, Mira, Tuazon, Julian, Napoli, Eleonora, Borlongan, Cesar V

“…Stroke remains a major cause of death and disability in the United States and around the world. Solid safety and efficacy profiles of novel stroke therapeutics…”
Get full text

Neuroprotective and neuroregenerative potential of pharmacologically-induced hypothermia with D-alanine D-leucine enkephalin in brain injury by Liska, M, Crowley, Marci, Tuazon, Julian, Borlongan, Cesar

“…Neurovascular disorders, such as traumatic brain injury and stroke, persist as leading causes of death and disability - thus, the search for novel therapeutic…”
Get full text

Mitochondrial targeting as a novel therapy for stroke by Russo, Eleonora, Nguyen, Hung, Lippert, Trenton, Tuazon, Julian, Borlongan, Cesar, Napoli, Eleonora

“…Stroke is a main cause of mortality and morbidity worldwide. Despite the increasing development of innovative treatments for stroke, most are unsuccessful in…”
Get full text

Neural Stem Cells by Tuazon, Julian P, Castelli, Vanessa, Lee, Jea-Young, Desideri, Giovambattista B, Stuppia, Liborio, Cimini, Anna Maria, Borlongan, Cesar V

“…Neural stem cell (NSC) transplantation has provided the basis for the development of potentially powerful new therapeutic cell-based strategies for a broad…”
Get more information

Human parthenogenetic neural stem cell grafts promote multiple regenerative processes in a traumatic brain injury model by Lee, Jea-Young, Acosta, Sandra, Tuazon, Julian P, Xu, Kaya, Nguyen, Hung, Lippert, Trenton, Liska, Michael G, Semechkin, Andrey, Garitaonandia, Ibon, Gonzalez, Rodolfo, Kern, Russell, Borlongan, Cesario V

“…International Stem Cell Corporation human parthenogenetic neural stem cells (ISC-hpNSC) have potential therapeutic value for patients suffering from traumatic…”
Get full text

Translating intracarotid artery transplantation of bone marrow‐derived NCS‐01 cells for ischemic stroke: Behavioral and histological readouts and mechanistic insights into stem cell therapy by Kaneko, Yuji, Lee, Jea‐Young, Tajiri, Naoki, Tuazon, Julian P., Lippert, Trenton, Russo, Eleonora, Yu, Seong‐Jin, Bonsack, Brooke, Corey, Sydney, Coats, Alexandreya B., Kingsbury, Chase, Chase, Thomas N., Koga, Minako, Borlongan, Cesar V.

“…The present study used in vitro and in vivo stroke models to demonstrate the safety, efficacy, and mechanism of action of adult human bone marrow‐derived…”
Get full text

Advancing stem cells: New therapeutic strategies for treating central nervous system disorders by Russo, Eleonora, Lippert, Trenton, Tuazon, Julian, Borlongan, Cesar

“…Given the prevalence and severity of these maladies and the promising evidence regarding stem cell transplantation in preclinical animal models, further…”
Get full text

A Gutsy Move for Cell-Based Regenerative Medicine in Parkinson's Disease: Targeting the Gut Microbiome to Sequester Inflammation and Neurotoxicity by Lee, Jea-Young, Tuazon, Julian P, Corey, Sydney, Bonsack, Brooke, Acosta, Sandra, Ehrhart, Jared, Sanberg, Paul R, Borlongan, Cesario V

“…Pharmaceuticals and cell-based regenerative medicine for Parkinson's disease (PD) offer palliative relief but do not arrest the disease progression. Cell…”
Get more information