Search Results - "Tümer, Nihal"

A Proteomic Evaluation of Sympathetic Activity Biomarkers of the Hypothalamus-Pituitary-Adrenal Axis by Western Blotting Technique Following Experimental Traumatic Brain Injury by Toklu, Hale Zerrin, Sakarya, Yasemin, Tümer, Nihal

“…Endocrine disorders and autonomic dysfunction are common paradigms following traumatic brain injury (TBI). Alterations in the hypothalamus-pituitary-adrenal…”
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Rapamycin Normalizes Serum Leptin by Alleviating Obesity and Reducing Leptin Synthesis in Aged Rats by Scarpace, Philip J, Matheny, Michael, Strehler, Kevin Y E, Toklu, Hale Zerrin, Kirichenko, Nataliya, Carter, Christy S, Morgan, Drake, Tümer, Nihal

“…This investigation examines whether a low intermittent dose of rapamycin will avoid the hyperlipidemia and diabetes-like syndrome associated with rapamycin…”
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Overpressure blast injury-induced oxidative stress and neuroinflammation response in rat frontal cortex and cerebellum by Toklu, Hale Z., Yang, Zhihui, Oktay, Sehkar, Sakarya, Yasemin, Kirichenko, Nataliya, Matheny, Michael K., Muller-Delp, Judy, Strang, Kevin, Scarpace, Philip J., Wang, Kevin K.W., Tümer, Nihal

“…[Display omitted] •Overpressure blast injury (OBI) induces oxidative stress and inflammation in lung and brain.•Repeated OBI causes edema and disrupts blood…”
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Prevention and reversal of diet-induced leptin resistance with a sugar-free diet despite high fat content by Shapiro, Alexandra, Tümer, Nihal, Gao, Yongxin, Cheng, Kit-Yan, Scarpace, Philip J.

“…Chronic consumption of a Western-type diet, containing both elevated sugar and fat, results in leptin resistance. We hypothesised that fructose, as part of the…”
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ACE2 activator diminazene aceturate reduces adiposity but preserves lean mass in young and old rats by Bruce, Erin B., Sakarya, Yasemin, Kirichenko, Nataliya, Toklu, Hale Z., Sumners, Colin, Morgan, Drake, Tümer, Nihal, Scarpace, Philip J., Carter, Christy S.

“…The obesity epidemic is multi-generational and is particularly debilitating in the aging population, necessitating the use of pharmaceutical interventions…”
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Rapamycin Versus Intermittent Feeding: Dissociable Effects on Physiological and Behavioral Outcomes When Initiated Early and Late in Life by Carter, Christy S, Khamiss, Dallas, Matheny, Michael, Toklu, Hale Z, Kirichenko, Nataliya, Strehler, Kevin Y E, Tümer, Nihal, Scarpace, Philip J, Morgan, Drake

“…Rapamycin, an inhibitor of the mammalian target of rapamycin pathway, has been shown to increase mammalian life span; less is known concerning its effect on…”
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Short-term exercise training protects against doxorubicin-induced cardiac mitochondrial damage independent of HSP72 by Kavazis, Andreas N, Smuder, Ashley J, Min, Kisuk, Tümer, Nihal, Powers, Scott K

“…Doxorubicin (Dox) is an antitumor agent used in cancer treatment, but its clinical use is limited due to cardiotoxicity. Although exercise training can defend…”
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Synergy Between Leptin Therapy and a Seemingly Negligible Amount of Voluntary Wheel Running Prevents Progression of Dietary Obesity in Leptin-Resistant Rats by Shapiro, Alexandra, Matheny, Michael, Zhang, Yi, Tümer, Nihal, Cheng, Kit-Yan, Rogrigues, Enda, Zolotukhin, Sergei, Scarpace, Philip J.

“…Synergy Between Leptin Therapy and a Seemingly Negligible Amount of Voluntary Wheel Running Prevents Progression of Dietary Obesity in Leptin-Resistant Rats…”
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Effect of High-Salt Diet on Age-Related High Blood Pressure and Hypothalamic Redox Signaling by Basgut, Bilgen, Whidden, Melissa A, Kirichenko, Nataliya, Woods, Mary, Erdos, Benedek, Scarpace, Philip J, Tümer, Nihal

“…The aim of this study was to investigate the effect of a high salt (HS) diet on age-related changes in blood pressure (BP) and the possible role played by…”
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Oestradiol and leptin have separate but additive anorexigenic effects and differentially target fat mass in rats by Côté, Isabelle, Green, Sara M., Yarrow, Joshua F., Conover, Christine F., Toklu, Hale Z., Morgan, Drake, Carter, Christy S., Tümer, Nihal, Scarpace, Philip J.

“…We recently showed that male rats exhibit lower hypophagia and body weight loss compared to female rats following central leptin delivery, suggesting a role…”
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Intracerebroventricular tempol administration in older rats reduces oxidative stress in the hypothalamus but does not change STAT3 signalling or SIRT1/AMPK pathway by Toklu, Hale Z, Scarpace, Philip J, Sakarya, Yasemin, Kirichenko, Nataliya, Matheny, Michael, Bruce, Erin B, Carter, Christy S, Morgan, Drake, Tümer, Nihal

“…Hypothalamic inflammation and increased oxidative stress are believed to be mechanisms that contribute to obesity…”
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Anorexic response to rapamycin does not appear to involve a central mechanism by Toklu, Hale Z., Bruce, Erin B., Sakarya, Yasemin, Carter, Christy S., Morgan, Drake, Matheny, Michael K., Kirichenko, Nataliya, Scarpace, Philip J., Tümer, Nihal

“…Summary The authors have previously demonstrated that a low and intermittent peripheral dose of rapamycin (1 mg/kg three times/week) to rats inhibited mTORC1…”
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Onset of leptin resistance shows temporal differences related to dose or pulsed treatment by Strehler, Kevin Y.E., Matheny, Michael, Kirichenko, Nataliya, Sakarya, Yasemin, Bruce, Erin, Toklu, Hale Zerrin, Carter, Christy S., Morgan, Drake, Tümer, Nihal, Scarpace, Philip J.

“…Leptin administration results in leptin resistance presenting a significant barrier to therapeutic use of leptin. Consequently, we examined two hypotheses. The…”
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Lifelong caloric restriction prevents age-induced oxidative stress in the sympathoadrenal system of Fischer 344 x Brown Norway rats by Whidden, Melissa A., Kirichenko, Nataliya, Halici, Zekai, Erdos, Benedek, Foster, Thomas C., Tümer, Nihal

“…► Lipid peroxidation and tyrosine nitration are elevated in the adrenal medulla of aged rats. ► Endogenous antioxidant enzymes are depleted in the hypothalamus…”
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Assessing neuro-systemic & behavioral components in the pathophysiology of blast-related brain injury by Kobeissy, Firas, Mondello, Stefania, Tümer, Nihal, Toklu, Hale Z, Whidden, Melissa A, Kirichenko, Nataliya, Zhang, Zhiqun, Prima, Victor, Yassin, Walid, Anagli, John, Chandra, Namas, Svetlov, Stan, Wang, Kevin K W

“…Among the U.S. military personnel, blast injury is among the leading causes of brain injury. During the past decade, it has become apparent that even blast…”
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The effects of enalapril and losartan on mechanical ventilation–induced sympathoadrenal activation and oxidative stress in rats by Toklu, Hale Zerrin, PhD, Kwon, Oh-Sung, PhD, Sakarya, Yasemin, Powers, Scott K., PhD, Llinas, Katherine, Kirichenko, Nataliya, MSc, Sollanek, Kurt J., MSc, Wiggs, Michael P., PhD, Smuder, Ashley J., PhD, Talbert, Erin E., PhD, Scarpace, Philip J., PhD, Tümer, Nihal, PhD

“…Abstract Background Mechanical ventilation (MV) is a method of maintaining appropriate gas exchange in patients who are unable to sustain adequate alveolar…”
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Leptin antagonist reverses hypertension caused by leptin overexpression, but fails to normalize obesity-related hypertension by Tümer, Nihal, Erdös, Benedek, Matheny, Michael, Cudykier, Idan, Scarpace, Philip J

“…OBJECTIVEThe present study employed a rat leptin antagonist to evaluate the role of elevated leptin in obesity-associated hypertension. METHODSFirst, leptin…”
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Central overexpression of leptin antagonist reduces wheel running and underscores importance of endogenous leptin receptor activity in energy homeostasis by Matheny, Michael, Zhang, Yi, Shapiro, Alexandra, Tümer, Nihal, Scarpace, Philip J

“…We used recombinant adeno-associated virus (rAAV)-mediated gene delivery to overexpress a mutant of rat leptin yielding a protein that acts as a neutral leptin…”
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Leptin-Induced Leptin Resistance Reveals Separate Roles for the Anorexic and Thermogenic Responses in Weight Maintenance by Scarpace, Philip J, Matheny, Michael, Zhang, Yi, Shek, Eugene W, Prima, Victor, Zolotukhin, Sergei, Tümer, Nihal

“…The purpose of this study was to determine whether leptin induces leptin resistance by examining the temporal attenuation of the anorexic and energy…”
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Hypertensive effects of central angiotensin II infusion and restraint stress are reduced with age by ERDOS, Benedek, CUDYKIER, Idan, WOODS, Mary, BASGUT, Bilgen, WHIDDEN, Melissa, TAWIL, Rabih, CARDOUNEL, Arturo J, TURNERS, Nihal

“…We investigated the effect of age on cardiovascular responses mediated by central angiotensin II (AngII) after intracerebroventricular infusion of AngII, and…”
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