Search Results - "Tu, Zhuchi"

Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9 by Chen, Yongchang, Zheng, Yinghui, Kang, Yu, Yang, Weili, Niu, Yuyu, Guo, Xiangyu, Tu, Zhuchi, Si, Chenyang, Wang, Hong, Xing, Ruxiao, Pu, Xiuqiong, Yang, Shang-Hsun, Li, Shihua, Ji, Weizhi, Li, Xiao-Jiang

“…CRISPR/Cas9 has been used to genetically modify genomes in a variety of species, including non-human primates. Unfortunately, this new technology does cause…”
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Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos by Tu, Zhuchi, Yang, Weili, Yan, Sen, Yin, An, Gao, Jinquan, Liu, Xudong, Zheng, Yinghui, Zheng, Jiezhao, Li, Zhujun, Yang, Su, Li, Shihua, Guo, Xiangyu, Li, Xiao-Jiang

“…CRISPR-Cas9 is a powerful new tool for genome editing, but this technique creates mosaic mutations that affect the efficiency and precision of its ability to…”
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CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys by Yang, Weili, Liu, Yunbo, Tu, Zhuchi, Xiao, Chong, Yan, Sen, Ma, Xishan, Guo, Xiangyu, Chen, Xiusheng, Yin, Peng, Yang, Zhengyi, Yang, Su, Jiang, Tianzi, Li, Shihua, Qin, Chuan, Li, Xiao-Jiang

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CRISPR/Cas9-mediated disruption of SHANK3 in monkey leads to drug-treatable autism-like symptoms by Tu, Zhuchi, Zhao, Hui, Li, Bang, Yan, Sen, Wang, Lu, Tang, Yongjin, Li, Zhujun, Bai, Dazhang, Li, Caijuan, Lin, Yingqi, Li, Yuefeng, Liu, Jianrong, Xu, Hao, Guo, Xiangyu, Jiang, Yong-hui, Zhang, Yong Q, Li, Xiao-Jiang

“…Abstract Monogenic mutations in the SHANK3 gene, which encodes a postsynaptic scaffold protein, play a causative role in autism spectrum disorder (ASD)…”
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CRISPR/Cas9: a powerful genetic engineering tool for establishing large animal models of neurodegenerative diseases by Tu, Zhuchi, Yang, Weili, Yan, Sen, Guo, Xiangyu, Li, Xiao-Jiang

“…Animal models are extremely valuable to help us understand the pathogenesis of neurodegenerative disorders and to find treatments for them. Since large animals…”
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Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates by Zhao, Hui, Wang, Qiqi, Yan, Ting, Zhang, Yu, Xu, Hui-juan, Yu, Hao-peng, Tu, Zhuchi, Guo, Xiangyu, Jiang, Yong-hui, Li, Xiao-jiang, Zhou, Huihui, Zhang, Yong Q.

“…Despite the substantial progress made in identifying genetic defects in autism spectrum disorder (ASD), the etiology for majority of ASD individuals remains…”
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PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis by Yang, Weili, Guo, Xiangyu, Tu, Zhuchi, Chen, Xiusheng, Han, Rui, Liu, Yanting, Yan, Sen, Wang, Qi, Wang, Zhifu, Zhao, Xianxian, Zhang, Yunpeng, Xiong, Xin, Yang, Huiming, Yin, Peng, Wan, Huida, Chen, Xingxing, Guo, Jifeng, Yan, Xiao-Xin, Liao, Lujian, Li, Shihua, Li, Xiao-Jiang

“…In vitro studies have established the prevalent theory that the mitochondrial kinase PINK1 protects neurodegeneration by removing damaged mitochondria in…”
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Application of CRISPR/Cas9 System in Establishing Large Animal Models by Lin, Yingqi, Li, Jun, Li, Caijuan, Tu, Zhuchi, Li, Shihua, Li, Xiao-Jiang, Yan, Sen

“…The foundation for investigating the mechanisms of human diseases is the establishment of animal models, which are also widely used in agricultural industry,…”
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A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin by Li, Caijuan, Lin, Yingqi, Chen, Yizhi, Song, Xichen, Zheng, Xiao, Li, Jiawei, He, Jun, Chen, Xiusheng, Huang, Chunhui, Wang, Wei, Wu, Jianhao, Wu, Jiaxi, Gao, Jiale, Tu, Zhuchi, Li, Xiao‐Jiang, Yan, Sen, Li, Shihua

“…Abstract Accumulation of misfolded proteins leads to many neurodegenerative diseases that can be treated by lowering or removing mutant proteins. Huntington's…”
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Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys by Tu, Zhuchi, Yan, Sen, Han, Bofeng, Li, Caijuan, Liang, Weien, Lin, Yingqi, Ding, Yongyan, Wei, Huiyi, Wang, Lu, Xu, Hao, Ye, Jianmeng, Li, Bang, Li, Shihua, Li, Xiao-Jiang

“…Tauopathy, characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau, and the accumulation of Aβ oligomers,…”
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Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing by Zheng, Xiao, Huang, Chunhui, Lin, Yingqi, Han, Bofeng, Chen, Yizhi, Li, Caijuan, Li, Jiawei, Ding, Yongyan, Song, Xichen, Wang, Wei, Liang, Weien, Wu, Jianhao, Wu, Jiaxi, Gao, Jiale, Wei, Chengxi, Zhang, Xudong, Tu, Zhuchi, Yan, Sen

“…Severe combined immunodeficiency (SCID) encompasses a range of inherited disorders that lead to a profound deterioration of the immune system. Among the…”
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Intravenous AAV9 administration results in safe and widespread distribution of transgene in the brain of mini-pig by Lin, Yingqi, Li, Caijuan, Wang, Wei, Li, Jiawei, Huang, Chunhui, Zheng, Xiao, Liu, Zhaoming, Song, Xichen, Chen, Yizhi, Gao, Jiale, Wu, Jianhao, Wu, Jiaxi, Tu, Zhuchi, Lai, Liangxue, Li, Xiao-Jiang, Li, Shihua, Yan, Sen

“…Animal models are important for understanding the pathogenesis of human diseases and for developing and testing new drugs. Pigs have been widely used in the…”
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CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate by Li, Bang, Zhao, Hui, Tu, Zhuchi, Yang, Weili, Han, Rui, Wang, Lu, Luo, Xiaopeng, Pan, Mingtian, Chen, Xiusheng, Zhang, Jiawei, Xu, Huijuan, Guo, Xiangyu, Yan, Sen, Yin, Peng, Zhao, Zhiguang, Liu, Jianrong, Luo, Yafeng, Li, Yuefeng, Yang, Zhengyi, Zhang, Baogui, Tan, Zhiqiang, Xu, Hao, Jiang, Tianzi, Jiang, Yong-hui, Li, Shihua, Zhang, Yong Q., Li, Xiao-Jiang

“…Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that affects social interaction and behavior. Mutations in the gene encoding…”
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A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington’s Disease by Yan, Sen, Tu, Zhuchi, Liu, Zhaoming, Fan, Nana, Yang, Huiming, Yang, Su, Yang, Weili, Zhao, Yu, Ouyang, Zhen, Lai, Chengdan, Yang, Huaqiang, Li, Li, Liu, Qishuai, Shi, Hui, Xu, Guangqing, Zhao, Heng, Wei, Hongjiang, Pei, Zhong, Li, Shihua, Lai, Liangxue, Li, Xiao-Jiang

“…Huntington’s disease (HD) is characterized by preferential loss of the medium spiny neurons in the striatum. Using CRISPR/Cas9 and somatic nuclear transfer…”
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Use of CRISPR/Cas9 to model brain diseases by Yan, Sen, Tu, Zhuchi, Li, Shihua, Li, Xiao-Jiang

“…•Genomic editing has been used to generate animal models of human diseases to mimic neurological symptoms and to study disease pathogenesis and treatments.•Of…”
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Altered neurogenesis and disrupted expression of synaptic proteins in prefrontal cortex of SHANK3-deficient non-human primate by Zhao, Hui, Tu, Zhuchi, Xu, Huijuan, Yan, Sen, Yan, Huanhuan, Zheng, Yinghui, Yang, Weili, Zheng, Jiezhao, Li, Zhujun, Tian, Rui, Lu, Youming, Guo, Xiangyu, Jiang, Yong-hui, Li, Xiao-Jiang, Zhang, Yong Q

“…Dear Editor, Despite substantial progress made toward under- standing the molecular changes contributing to autism spectrum disorders （ASD）, the…”
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TBN improves motor function and prolongs survival in a TDP-43M337V mouse model of ALS by Huang, Chunhui, Li, Jun, Zhang, Guiliang, Lin, Yingqi, Li, Caijuan, Zheng, Xiao, Song, Xichen, Han, Bofeng, Guo, Baojian, Tu, Zhuchi, Zhang, Jun, Sun, Yewei, Wang, Yuqiang, Zhang, Zaijun, Yan, Sen

“…Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are serious neurodegenerative diseases. Although their pathogenesis is…”
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Large animal models for Huntington's disease research by Han, Bofeng, Liang, Weien, Li, Xiao-Jiang, Li, Shihua, Yan, Sen, Tu, Zhuchi

“…Huntington's disease (HD) is a hereditary neurodegenerative disorder for which there is currently no effective treatment available. Consequently, the…”
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Deficiency of parkin causes neurodegeneration and accumulation of pathological α-synuclein in monkey models by Han, Rui, Wang, Qi, Xiong, Xin, Chen, Xiusheng, Tu, Zhuchi, Li, Bang, Zhang, Fei, Chen, Chunyu, Pan, Mingtian, Xu, Ting, Chen, Laiqiang, Wang, Zhifu, Liu, Yanting, He, Dajian, Guo, Xiangyu, He, Feng, Wu, Peng, Yin, Peng, Liu, Yunbo, Yan, Xiaoxin, Li, Shihua, Li, Xiao-Jiang, Yang, Weili

“…Parkinson's disease (PD) is characterized by age-dependent neurodegeneration and the accumulation of toxic phosphorylated α-synuclein (pS129-α-syn). The…”
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Deficiency of parkin causes neurodegeneration and accumulation of pathological [alpha]-synuclein in monkey models by Han, Rui, Wang, Qi, Xiong, Xin, Chen, Xiusheng, Tu, Zhuchi, Li, Bang, Zhang, Fei, Chen, Chunyu, Pan, Mingtian, Xu, Ting, Chen, Laiqiang, Wang, Zhifu, Liu, Yanting, He, Dajian, Guo, Xiangyu, He, Feng, Wu, Peng, Yin, Peng, Liu, Yunbo, Yan, Xiaoxin, Li, Shihua, Li, Xiao-Jiang, Yang, Weili

“…Parkinson's disease (PD) is characterized by age-dependent neurodegeneration and the accumulation of toxic phosphorylated [alpha]-synuclein…”
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