Search Results - "Tu, Lichan"

Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis by Tu, Lichan, Su, Ping, Zhang, Zhongren, Gao, Linhui, Wang, Jiadian, Hu, Tianyuan, Zhou, Jiawei, Zhang, Yifeng, Zhao, Yujun, Liu, Yuan, Song, Yadi, Tong, Yuru, Lu, Yun, Yang, Jian, Xu, Cao, Jia, Meirong, Peters, Reuben J., Huang, Luqi, Gao, Wei

“…Triptolide is a trace natural product of Tripterygium wilfordii . It has antitumor activities, particularly against pancreatic cancer cells. Identification of…”
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Identification and functional characterization of squalene epoxidases and oxidosqualene cyclases from Tripterygium wilfordii by Liu, Yuan, Zhou, Jiawei, Hu, Tianyuan, Lu, Yun, Gao, Linhui, Tu, Lichan, Gao, Jie, Huang, Luqi, Gao, Wei

“…Key message We cloned two squalene epoxidases and five oxidosqualene cyclases, and identified their function using CRISPR/Cas9 tool and yeast heterologous…”
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A cytochrome P450 CYP81AM1 from Tripterygium wilfordii catalyses the C-15 hydroxylation of dehydroabietic acid by Wang, Jiadian, Su, Ping, Gao, Linhui, Zhang, Yifeng, Wang, Jian, Tu, Lichan, Zhao, Yujun, Lu, Yun, Yin, Yan, Huang, Luqi, Gao, Wei

“…Main conclusion A novel cytochrome P450 from Tripterygium wilfordii , CYP81AM1, specifically catalyses the C-15 hydroxylation of dehydroabietic acid. This is…”
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Tandemly duplicated CYP82Ds catalyze 14-hydroxylation in triptolide biosynthesis and precursor production in Saccharomyces cerevisiae by Zhang, Yifeng, Gao, Jie, Ma, Lin, Tu, Lichan, Hu, Tianyuan, Wu, Xiaoyi, Su, Ping, Zhao, Yujun, Liu, Yuan, Li, Dan, Zhou, Jiawei, Yin, Yan, Tong, Yuru, Zhao, Huan, Lu, Yun, Wang, Jiadian, Gao, Wei, Huang, Luqi

“…Triptolide is a valuable multipotent antitumor diterpenoid in Tripterygium wilfordii , and its C-14 hydroxyl group is often selected for modification to…”
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The chromosome-level reference genome assembly for Panax notoginseng and insights into ginsenoside biosynthesis by Jiang, Zhouqian, Tu, Lichan, Yang, Weifei, Zhang, Yifeng, Hu, Tianyuan, Ma, Baowei, Lu, Yun, Cui, Xiuming, Gao, Jie, Wu, Xiaoyi, Tong, Yuru, Zhou, Jiawei, Song, Yadi, Liu, Yuan, Liu, Nan, Huang, Luqi, Gao, Wei

“…Panax notoginseng, a perennial herb of the genus Panax in the family Araliaceae, has played an important role in clinical treatment in China for thousands of…”
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A novel strategy to enhance terpenoids production using cambial meristematic cells of Tripterygium wilfordii Hook. f by Song, Yadi, Chen, Shang, Wang, Xiujuan, Zhang, Rui, Tu, Lichan, Hu, Tianyuan, Liu, Xihong, Zhang, Yifeng, Huang, Luqi, Gao, Wei

“…Hook. f. ( ) is an important medicinal plant with anti-inflammatory, immunosuppressive and anti-tumor activities. The main bioactive ingredients are…”
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Genome‐wide analysis of MYB family genes in Tripterygium wilfordii and their potential roles in terpenoid biosynthesis by Xia, Meng, Tu, Lichan, Liu, Yuan, Jiang, Zhouqian, Wu, Xiaoyi, Gao, Wei, Huang, Luqi

“…Terpenoids are a class of significant bioactive components in the woody vine of Tripterygium wilfordii. Previous studies have shown that MYB transcription…”
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Author Correction: Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis by Tu, Lichan, Su, Ping, Zhang, Zhongren, Gao, Linhui, Wang, Jiadian, Hu, Tianyuan, Zhou, Jiawei, Zhang, Yifeng, Zhao, Yujun, Liu, Yuan, Song, Yadi, Tong, Yuru, Lu, Yun, Yang, Jian, Xu, Cao, Jia, Meirong, Peters, Reuben J., Huang, Luqi, Gao, Wei

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Probing the Single Key Amino Acid Responsible for the Novel Catalytic Function of ent -Kaurene Oxidase Supported by NADPH-Cytochrome P450 Reductases in Tripterygium wilfordii by Su, Ping, Guan, Hongyu, Zhang, Yifeng, Wang, Xing, Gao, Linhui, Zhao, Yujun, Hu, Tianyuan, Zhou, Jiawei, Ma, Baowei, Tu, Lichan, Tong, Yuru, Huang, Luqi, Gao, Wei

“…produces not only -kaurene, which is an intermediate of gibberellin (GA) biosynthesis in flowering plants, but also 16α-hydroxy- -kaurane, whose physiological…”
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Mechanistic analysis for the origin of diverse diterpenes in Tripterygium wilfordii by Tu, Lichan, Cai, Xinbo, Zhang, Yifeng, Tong, Yuru, Wang, Jian, Su, Ping, Lu, Yun, Hu, Tianyuan, Luo, Yunfeng, Wu, Xiaoyi, Li, Dan, Huang, Luqi, Gao, Wei

“…Tripterygium wilfordii is a valuable medicinal plant rich in biologically active diterpenoids, but there are few studies on the origins of these diterpenoids…”
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Friedelane-type triterpene cyclase in celastrol biosynthesis from Tripterygium wilfordii and its application for triterpenes biosynthesis in yeast by Zhou, Jiawei, Hu, Tianyuan, Gao, Linhui, Su, Ping, Zhang, Yifeng, Zhao, Yujun, Chen, Shang, Tu, Lichan, Song, Yadi, Wang, Xing, Huang, Luqi, Gao, Wei

“…Celastrol is a promising bioactive compound isolated from Tripterygium wilfordii and has been shown to possess many encouraging preclinical applications…”
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Engineering chimeric diterpene synthases and isoprenoid biosynthetic pathways enables high-level production of miltiradiene in yeast by Hu, Tianyuan, Zhou, Jiawei, Tong, Yuru, Su, Ping, Li, Xinlin, Liu, Yuan, Liu, Nan, Wu, Xiaoyi, Zhang, Yifeng, Wang, Jiadian, Gao, Linhui, Tu, Lichan, Lu, Yun, Jiang, Zhouqian, Zhou, Yongjin J., Gao, Wei, Huang, Luqi

“…Miltiradiene is a key intermediate in the biosynthesis of many important natural diterpene compounds with significant pharmacological activity, including…”
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MYB transcription factors in plants: A comprehensive review of their discovery, structure, classification, functional diversity and regulatory mechanism by Wu, Xiaoyi, Xia, Meng, Su, Ping, Zhang, Yifeng, Tu, Lichan, Zhao, Huan, Gao, Wei, Huang, Luqi, Hu, Yating

“…The MYB transcription factor (TF) family is one of the largest families in plants and performs highly diverse regulatory functions, particularly in relation to…”
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Probing the functions of friedelane‐type triterpene cyclases from four celastrol‐producing plants by Lu, Yun, Luo, Yunfeng, Zhou, Jiawei, Hu, Tianyuan, Tu, Lichan, Tong, Yuru, Su, Ping, Liu, Yuan, Wang, Jiadian, Jiang, Zhouqian, Wu, Xiaoyi, Chen, Xiaochao, Huang, Luqi, Gao, Wei

“…SUMMARY Triterpenes are among the most diverse plant natural products, and their diversity is closely related to various triterpene skeletons catalyzed by…”
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Cytochrome P450 catalyses the 29-carboxyl group formation of celastrol by Zhou, Jiawei, Hu, Tianyuan, Liu, Yuan, Tu, Lichan, Song, Yadi, Lu, Yun, Zhang, Yifeng, Tong, Yuru, Zhao, Yujun, Su, Ping, Wu, Xiaoyi, Huang, Luqi, Gao, Wei

“…Celastrol, a potent anticancer and anti-obesity drug, was first isolated from Tripterygium wilfordii Hook. f. and it is produced in small quantities in many…”
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CYP72D19 from Tripterygium wilfordii catalyzes C-2 hydroxylation of abietane-type diterpenoids by Gao, Jie, Ma, Lin, Liu, Yuan, Tu, Lichan, Wu, Xiaoyi, Wang, Jian, Li, Dan, Zhang, Xianan, Gao, Wei, Zhang, Yifeng, Liu, Changli

“…Key message CYP72D19, the first functional gene of the CYP72D subfamily, catalyzes the C-2 hydroxylation of abietane-type diterpenoids . The abietane-type…”
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Functional characterization and substrate promiscuity of sesquiterpene synthases from Tripterygium wilfordii by Tong, Yuru, Hu, Tianyuan, Tu, Lichan, Chen, Kang, Liu, Tiezheng, Su, Ping, Song, Yadi, Liu, Yuan, Huang, Luqi, Gao, Wei

“…Acyclic terpenes, commonly found in plants, are of high physiological importance and commercial value, and their diversity was controlled by different terpene…”
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Characterization of the Cytochrome P450 CYP716C52 in Celastrol Biosynthesis and Its Applications in Engineered Saccharomyces cerevisiae by Lu, Yun, Liu, Yuan, Zhang, Yifeng, Gao, Haiyun, Chen, Xiaochao, Tu, Lichan, Luo, Yunfeng, Jiang, Zhouqian, Yin, Yan, Zhou, Jiawei, Hu, Tianyuan, Wu, Xiaoyi, Wang, Jiadian, Gao, Wei, Huang, Luqi

“…Celastrol is a bioactive pentacyclic triterpenoid with promising therapeutic effects that is mainly distributed in Celastraceae plants. Although some enzymes…”
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Structural and Catalytic Insight into the Unique Pentacyclic Triterpene Synthase TwOSC by Luo, Yunfeng, Ma, Xiaoli, Qiu, Yufan, Lu, Yun, Shen, Siyu, Li, Yang, Gao, Haiyun, Chen, Kang, Zhou, Jiawei, Hu, Tianyuan, Tu, Lichan, Zhao, Huan, Li, Dan, Leng, Faqiang, Gao, Wei, Jiang, Tao, Liu, Changli, Huang, Luqi, Wu, Ruibo, Tong, Yuru

“…The oxidosqualene cyclase (OSC) catalyzed cyclization of the linear substrate (3S)‐2,3‐oxidosqualene to form diverse pentacyclic triterpenoid (PT) skeletons is…”
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Analysis of the role of geranylgeranyl diphosphate synthase 8 from Tripterygium wilfordii in diterpenoids biosynthesis by Su, Ping, Gao, Linhui, Tong, Yuru, Guan, Hongyu, Liu, Shuang, Zhang, Yifeng, Zhao, Yujun, Wang, Jiadian, Hu, Tianyuan, Tu, Lichan, Zhou, Jiawei, Ma, Baowei, Huang, Luqi, Gao, Wei

“…•GGPPS1, GGPPS7 and GGPPS8 catalyzed the successive addition of IPP to DMAPP, GPP and FPP to form GGPP.•GPPS.SSU was inactive alone but interacted with GGPPS1,…”
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