Search Results - "Tu, Liangxing"

Nanocrystal-Loaded Micelles for the Enhanced In Vivo Circulation of Docetaxel by Cheng, Meng, Liu, Qiaoming, Gan, Tiantian, Fang, Yuanying, Yue, Pengfei, Sun, Yongbing, Jin, Yi, Feng, Jianfang, Tu, Liangxing

“…Prolonging in vivo circulation has proved to be an efficient route for enhancing the therapeutic effect of rapidly metabolized drugs. In this study, we aimed…”
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Research Progress on the Mechanism of Nanoparticles Crossing the Intestinal Epithelial Cell Membrane by He, Yunjie, Cheng, Meng, Yang, Ruyue, Li, Haocheng, Lu, Zhiyang, Jin, Yi, Feng, Jianfang, Tu, Liangxing

“…Improving the stability of drugs in the gastrointestinal tract and their penetration ability in the mucosal layer by implementing a nanoparticle delivery…”
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Resveratrol-Loaded Dissolving Microneedles: Fabrication and in vitro Evaluation by Xing, Banghuai, Luo, Qian, Gan, Tiantian, Jin, Yi, Feng, Jianfang, Cheng, Meng, Tu, Liangxing

“…Abstract Resveratrol (Res), an active ingredient derived from a multitude of plants, exhibits multiple pharmacological activities. However, its poor water…”
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Multi-functional chitosan copolymer modified nanocrystals as oral andrographolide delivery systems for enhanced bioavailability and anti-inflammatory efficacy by Liu, Wan, Cheng, Meng, Lu, Zhiyang, Li, Haocheng, Feng, Yulin, Jin, Yi, Yang, Shilin, Feng, Jianfang, Tu, Liangxing

“…Modifying nanocrystals with functional materials have been common strategy to enlarge the enhancing ability on oral absorption via nanocrystals; however,…”
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High‐performance liquid chromatography‐tandem mass spectrometry method for determination of peramivir in rat plasma using the simple protein precipitation pretreatment by Ke, Xin, Nan, Gu, Lili, Wan, Jiaai, Zhou, Ziqian, Huang, Liangxing, Tu, Qi, Zhang, Heyun, Nie, Yongbing, Sun

“…A high‐performance liquid chromatography‐tandem mass spectrometry method has been developed for the determination of peramivir in rat plasma in the present…”
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Optimisation of novel 4, 8-disubstituted dihydropyrimido[5,4-b][1,4]oxazine derivatives as potent GPR 119 agonists by Fang, Yuanying, Zhang, Shaokun, Li, Min, Xiong, Lijuan, Tu, Liangxing, Xie, Saisai, Jin, Yi, Liu, Yanhua, Yang, Zunhua, Liu, Ronghua

“…GPR119 is a promising target for discovery of anti-type 2 diabetes mellitus agents. We described the optimisation of a novel series of…”
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Multi-functional chitosan polymeric micelles as oral paclitaxel delivery systems for enhanced bioavailability and anti-tumor efficacy by Chen, Tian'e, Tu, Liangxing, Wang, Ge, Qi, Na, Wu, Wei, Zhang, Wei, Feng, Jianfang

“…In this paper, we intended to synthesize a GA-CS-TPGS copolymer and construct paclitaxel micelles by using this copolymer. Aiming to use the enhanced…”
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Mechanisms for oral absorption enhancement of drugs by nanocrystals by Liu, Jiali, Tu, Liangxing, Cheng, Meng, Feng, Jianfang, Jin, Yi

“…Currently, numerous new compounds suffer from poor water solubility, hindering their oral absorption from the gastrointestinal tract and thereby limiting their…”
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Fabrication of Luteolin Nanoemulsion by Box-Behnken Design to Enhance its Oral Absorption Via Lymphatic Transport by Tu, Liangxing, Wang, Ju, Sun, Yongbing, Wan, Yang

“…Intestinal lymphatic transport offers an alternative and effective way to deliver drugs, such as avoiding first-pass metabolism, enhancing oral…”
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Fabrication of ultra-small nanocrystals by formation of hydrogen bonds: In vitro and in vivo evaluation by Tu, Liangxing, Cheng, Meng, Sun, Yongbing, Fang, Yuanying, Liu, Jiali, Liu, Wan, Feng, Jianfang, Jin, Yi

“…In this paper, we intended to fabricate ultra-small nanocrystals (below 50 nm) by formation of hydrogen bonds between model drug and stabilizer. The absorption…”
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Vesicular drug delivery systems for oral absorption enhancement by Zou, Linghui, Cheng, Meng, Hu, Kaili, Feng, Jianfang, Tu, Liangxing

“…Oral administration is the most acceptable route of drug delivery at this stage due to its convenience, safety, and non-invasiveness. However, drugs given…”
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Design and evaluation of inhalable nanocrystals embedded microparticles with enhanced redispersibility and bioavailability for breviscapine by Chen, Yingchong, Gui, Yan, Luo, Yijing, Liu, Yang, Tu, Liangxing, Ma, Yueqin, Yue, Pengfei, Yang, Ming

“…The purpose of this study was to design novel inhalable nanocrystals embedded microparticles for pulmonary delivery of breviscapine (BVC). The TPGS modified…”
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The construction of puerarin nanocrystals and its pharmacokinetic and in vivo–in vitro correlation (IVIVC) studies on beagle dog by Yi, Yueneng, Tu, Liangxing, Hu, Kaili, Wu, Wei, Feng, Jianfang

“…•The nanocrystals prepared was smaller than 229nm.•Redispersion of nanocrystals powder was performed above 30°C.•A fine in vivo–in vitro correlation was…”
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Fabrication of Fine Puerarin Nanocrystals by Box–Behnken Design to Enhance Intestinal Absorption by Cheng, Meng, Yuan, Fangying, Liu, Jiali, Liu, Wan, Feng, Jianfang, Jin, Yi, Tu, Liangxing

“…Puerarin is widely used as a therapeutic agent to cardiovascular diseases in clinics in China through intravenous administration, which could elicit adverse…”
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Improved Bioavailability and Antitumor Effect of Docetaxel by TPGS Modified Proniosomes: In Vitro and In Vivo Evaluations by Liu, Helong, Tu, Liangxing, Zhou, Yongxin, Dang, Zefang, Wang, Luting, Du, Junfeng, Feng, Jianfang, Hu, Kaili

“…A novel oral drug delivery system, TPGS modified docetaxel proniosomes (DTX-TPGS-PNs), was designed to enhance the oral bioavailability and antitumor…”
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Improving Oral Bioavailability of Luteolin Nanocrystals by Surface Modification of Sodium Dodecyl Sulfate by Liu, Jiali, Sun, Yongbing, Cheng, Meng, Liu, Qiaoming, Liu, Wan, Gao, Chao, Feng, Jianfang, Jin, Yi, Tu, Liangxing

“…Luteolin suffers from drawbacks like low solubility and bioavailability, thus hindering its application in the clinic. In this study, we employed sodium…”
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Intestinal transporters and oral absorption enhancing strategies based on these transporters by Wang, Ju, Sun, Yongbing, Meng, Lingbang, Feng, Jianfang, Cheng, Meng, Tu, Liangxing

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Self-Assembled Micelles Based on Ginsenoside Rg5 for the Targeted Treatment of PTX-Resistant Tumors by Gao, Feiyan, Ma, Zhongyi, Luo, Xing, Wang, Yahua, Liu, Xinlong, Tang, Mei, Chen, Junyu, Tu, Liangxing, Ouyang, Defang, Zheng, Ji, Li, Chong

“…Paclitaxel (PTX) is one of the first-line drugs for prostate cancer (PC) treatment. However, the poor water solubility, inadequate specific targeting ability,…”
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Effects of particle size on the pharmacokinetics of puerarin nanocrystals and microcrystals after oral administration to rat by Tu, Liangxing, Yi, Yueneng, Wu, Wei, Hu, Fuqiang, Hu, Kaili, Feng, Jianfang

“…With the decreasing of particle size, an increasing of absolute bioavailability (Fa) and a decreasing of clearance rate (CL/F) were observed for puerarin…”
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Bifunctional and Unusual Amino Acid β- or γ‑Ester Prodrugs of Nucleoside Analogues for Improved Affinity to ATB0,+ and Enhanced Metabolic Stability: An Application to Floxuridine by Sun, Yongbing, Ke, Yu, Li, Chunshi, Wang, Jian, Tu, Liangxing, Hu, Lvjiang, Jin, Yi, Chen, Hao, Gong, Jianping, Yu, Zhiqiang

“…Floxuridine (FUdR, 5-fluoro-2-deoxyuridine) was widely used in patients with tumor. But the poor activity and severe side effects have been observed in the…”
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