Search Results - "Tu, Guogang"

Molecular dynamics-guided receptor-dependent 4D-QSAR studies of HDACs inhibitors by Hu, Zhihao, Lin, Qianxia, Liu, Haiyun, Zhao, Tiansheng, Yang, Bowen, Tu, Guogang

“…Histone deacetylases (HDACs) were highlighted as a novel category of anticancer targets. Several HDACs inhibitors were approved for therapeutic use in cancer…”
Get full text

5D-QSAR studies of 1H-pyrazole derivatives as EGFR inhibitors by Qin, Daogang, Zeng, Xiaoqi, Zhao, Tiansheng, Cai, Biying, Yang, Bowen, Tu, Guogang

“…Epidermal growth factor receptor (EGFR) is highlighted as a target for anticancer treatment. Several EGFR inhibitors were approved in cancer treatment…”
Get full text

Synthesis and Molecular Simulation Studies of Mandelic Acid Peptidomimetic Derivatives as Aminopeptidase N Inhibitors by Chen, Jiawei, Lv, Qiaoli, Tu, Guogang

“…The aminopeptidase N (APN) over-expressed in tumor cells plays a critical role in angiogenesis which makes the development of APN inhibitors an attractive…”
Get more information

Novel aminopeptidase N inhibitors derived from 1,3,4-thiadiazole scaffold by Tu, GuoGang, Li, ShaoHua, Huang, HuiMing, Li, Gang, Xiong, Fang, Mai, Xi, Zhu, HuaWei, Kuang, BinHai, Xu, Wen Fang

“…The synthesis and biological activity of a new series of 1,3,4-thiadiazole scaffold is described. The aminopeptidase N (APN/CD13), overexpressed in tumor…”
Get full text

3D-QSAR studies on flavone-8-acetic acid derivatives of aminopeptidase N inhibitors by Tang, XianShuai, Qu, QingLian, Kuang, BinHai, Li, ShaoHua, Tu, GuoGang

“…The 3D-QSARs models of 29 flavone-8-acetic acid derivatives of aminopeptidase N inhibitors were generated by applying the molecular interaction fields at…”
Get more information

Progress in the development of matrix metalloproteinase inhibitors by Tu, GuoGang, Xu, WenFang, Huang, HuiMing, Li, ShaoHua

“…Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases involved in the degradation and remodeling of extracellular matrix proteins that…”
Get more information

Synthesis and antiproliferative assay of 1,3,4-oxadiazole and 1,2,4-triazole derivatives in cancer cells by Tu, Guogang, Yan, Yugang, Chen, Xueying, Lv, Qiaoli, Wang, Jiaqi, Li, Shaohua

“…A series of new 1,3,4-oxadiazole and 1,2,4-triazole derivatives were synthesized. The structures were confirmed by IR, 1H-NMR, and MS. The compounds were…”
Get full text

HOMOLOGY MODEL, DOCKING ANALYSIS AND MOLECULAR DYNAMICS SIMULATION OF CANNABINOID CB2 RECEPTOR by XU, WEIDONG

Get full text

4D-QSAR studies of CB2 cannabinoid receptor inverse agonists: a comparison to 3D-QSAR by Zhang, Houpan, Lv, Qiaoli, Xu, Weidong, Lai, Xiaoping, Liu, Ya, Tu, Guogang

“…Over the years QSAR methods have developed from 2D-QSAR to more complex 4D-QSAR which features freedom of alignment and conformational flexibility of…”
Get full text

Synthesis and molecular simulation study of furoic peptidomimetic derivatives as potent aminopeptodase N inhibitors by Gao, Min, He, JunHua, Xu, WeiDong, Lai, XiaoPing, Liu, Fen, Tu, GuoGang

“…The aminopeptidase N (APN) plays a critical role in angiogenesis and is over-expressed in tumor cells. In this paper, we report the synthesis and enzyme…”
Get more information

3D-QSAR Studies, Molecular Dynamics Simulation and Free Energy Calculation of APN Inhibitors by Qu, Qinglian, Tang, Xianshuai, Kuang, Binhai, Li, Shaohua, Tu, Guogang

Get full text

Exploring ligand dissociation pathways from aminopeptidase N using random acceleration molecular dynamics simulation by Liu, Ya, Tu, GuoGang, Lai, XiaoPing, Kuang, BinHai, Li, ShaoHua

“…Aminopeptidase N (APN) is a zinc-dependent ectopeptidase involved in cell proliferation, secretion, invasion, and angiogenesis, and is widely recognized as an…”
Get full text

Design, synthesis and biological evaluation of CB1 cannabinoid receptor ligands derived from the 1,5-diarylpyrazole scaffold by Tu, GuoGang, Xiong, Fang, Huang, HuiMing, Kuang, BinHai, Li, ShaoHua

“…The CB1 receptor belongs to the G-protein-coupled receptor superfamily. CB1 antagonism has been considered as a new therapeutic target for the treatment of…”
Get more information