Search Results - "Tu, Christina"

Development and validation of a simplified method to generate human microglia from pluripotent stem cells by McQuade, Amanda, Coburn, Morgan, Tu, Christina H, Hasselmann, Jonathan, Davtyan, Hayk, Blurton-Jones, Mathew

“…Microglia, the principle immune cells of the brain, play important roles in neuronal development, homeostatic function and neurodegenerative disease. Recent…”
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Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease by McQuade, Amanda, Kang, You Jung, Hasselmann, Jonathan, Jairaman, Amit, Sotelo, Alexandra, Coburn, Morgan, Shabestari, Sepideh Kiani, Chadarevian, Jean Paul, Fote, Gianna, Tu, Christina H., Danhash, Emma, Silva, Jorge, Martinez, Eric, Cotman, Carl, Prieto, G. Aleph, Thompson, Leslie M., Steffan, Joan S., Smith, Ian, Davtyan, Hayk, Cahalan, Michael, Cho, Hansang, Blurton-Jones, Mathew

“…The discovery of TREM2 as a myeloid-specific Alzheimer’s disease (AD) risk gene has accelerated research into the role of microglia in AD. While TREM2 mouse…”
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Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo by Hasselmann, Jonathan, Coburn, Morgan A., England, Whitney, Figueroa Velez, Dario X., Kiani Shabestari, Sepideh, Tu, Christina H., McQuade, Amanda, Kolahdouzan, Mahshad, Echeverria, Karla, Claes, Christel, Nakayama, Taylor, Azevedo, Ricardo, Coufal, Nicole G., Han, Claudia Z., Cummings, Brian J., Davtyan, Hayk, Glass, Christopher K., Healy, Luke M., Gandhi, Sunil P., Spitale, Robert C., Blurton-Jones, Mathew

“…iPSC-derived microglia offer a powerful tool to study microglial homeostasis and disease-associated inflammatory responses. Yet, microglia are highly sensitive…”
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Axonal mRNA in Uninjured and Regenerating Cortical Mammalian Axons by Taylor, Anne M, Berchtold, Nicole C, Perreau, Victoria M, Tu, Christina H, Li Jeon, Noo, Cotman, Carl W

“…Using a novel microfluidic chamber that allows the isolation of axons without contamination by nonaxonal material, we have for the first time purified mRNA…”
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Author Correction: Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease by McQuade, Amanda, Kang, You Jung, Hasselmann, Jonathan, Jairaman, Amit, Sotelo, Alexandra, Coburn, Morgan, Shabestari, Sepideh Kiani, Chadarevian, Jean Paul, Fote, Gianna, Tu, Christina H., Danhash, Emma, Silva, Jorge, Martinez, Eric, Cotman, Carl, Prieto, G. Aleph, Thompson, Leslie M., Steffan, Joan S., Smith, Ian, Davtyan, Hayk, Cahalan, Michael, Cho, Hansang, Blurton-Jones, Mathew

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β-Amyloid impairs axonal BDNF retrograde trafficking by Poon, Wayne W, Blurton-Jones, Mathew, Tu, Christina H, Feinberg, Leila M, Chabrier, Meredith A, Harris, Joe W, Jeon, Noo Li, Cotman, Carl W

“…Abstract The neurotrophin, brain-derived neurotrophic factor (BDNF), is essential for synaptic function, plasticity and neuronal survival. At the axon…”
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Expression of Oct4 in human embryonic stem cells is dependent on nanotopographical configuration by Kong, Yen P., Tu, Christina H., Donovan, Peter J., Yee, Albert F.

“…The fate of adult stem cells can be influenced by physical cues, including nanotopography. However, the response of human embryonic stem cells (hESCs) to…”
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Patterned cell culture inside microfluidic devices by Rhee, Seog Woo, Taylor, Anne M, Tu, Christina H, Cribbs, David H, Cotman, Carl W, Jeon, Noo Li

“…This paper describes a simple plasma-based dry etching method that enables patterned cell culture inside microfluidic devices by allowing patterning, fluidic…”
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4-Hydroxytamoxifen probes for light-dependent spatiotemporal control of Cre-ER mediated reporter gene expression by Faal, Tannaz, Wong, Pamela T, Tang, Shengzhuang, Coulter, Alexa, Chen, Yumay, Tu, Christina H, Baker, James R, Choi, Seok Ki, Inlay, Matthew A

“…The tamoxifen inducible Cre-ER/loxP system provides tissue specific temporal control of gene recombination events, and can be used to induce expression of…”
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Differential regulation of inhibitors of apoptosis proteins in Alzheimer’s disease brains by Christie, Lori-Ann, Su, Joseph H, Tu, Christina H, Dick, Malcolm C, Zhou, Jun, Cotman, Carl W

“…Abstract Neuronal degeneration linked to apoptosis can be inhibited by a family of proteins known as inhibitors of apoptosis proteins (IAPs). We examined three…”
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Preparing e18 cortical rat neurons for compartmentalization in a microfluidic device by Harris, Joseph, Lee, Hyuna, Tu, Christina Tu, Cribbs, David, Cotman, Carl, Jeon, Noo Li

“…In this video, we demonstrate the preparation of E18 cortical rat neurons. E18 cortical rat neurons are obtained from E18 fetal rat cortex previously dissected…”
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Fas and Fas Ligand are associated with neuritic degeneration in the AD brain and participate in β-amyloid-induced neuronal death by Su, Joseph H, Anderson, Aileen J, Cribbs, David H, Tu, Christina, Tong, Liqi, Kesslack, Patrick, Cotman, Carl W

“…It has recently been suggested that neuronal cell death in response to many brain insults may be mediated by the upregulation of tumor necrosis factor receptor…”
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Microfluidic Multicompartment Device for Neuroscience Research by Taylor, Anne M, Rhee, Seog Woo, Tu, Christina H, Cribbs, David H, Cotman, Carl W, Jeon, Noo Li

“…This paper describes and characterizes a novel microfabricated neuronal culture device. This device combines microfabrication, microfluidic, and surface…”
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Prevention of apoptotic but not necrotic cell death following neuronal injury by neurotrophins signaling through the tyrosine kinase receptor by KIM, Dong H, XIURONG ZHAO, TU, Christina H, CASACCIA-BONNEFIL, Patrizia, CHAO, Moses V

“…Neurotrophins prevent the death of neurons during embryonal development and have potential as therapeutic agents. During development, neuronal death occurs…”
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Preparing E18 Cortical Rat Neurons for Compartmentalization in a Microfluidic Device by Harris, Joseph, Lee, Hyuna, Tu, Christina Tu, Cribbs, David, Cotman, Carl, Jeon, Noo Li

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Engineering an inhibitor-resistant human CSF1R variant for microglia replacement by Chadarevian, Jean Paul, Lombroso, Sonia I, Peet, Graham C, Hasselmann, Jonathan, Tu, Christina, Marzan, Dave E, Capocchi, Joia, Purnell, Freddy S, Nemec, Kelsey M, Lahian, Alina, Escobar, Adrian, England, Whitney, Chaluvadi, Sai, O'Brien, Carleigh A, Yaqoob, Fazeela, Aisenberg, William H, Porras-Paniagua, Matias, Bennett, Mariko L, Davtyan, Hayk, Spitale, Robert C, Blurton-Jones, Mathew, Bennett, F Chris

“…Hematopoietic stem cell transplantation (HSCT) can replace endogenous microglia with circulation-derived macrophages but has high mortality. To mitigate the…”
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The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model by Claes, Christel, England, Whitney E., Danhash, Emma P., Kiani Shabestari, Sepideh, Jairaman, Amit, Chadarevian, Jean Paul, Hasselmann, Jonathan, Tsai, Andy P., Coburn, Morgan A., Sanchez, Jessica, Lim, Tau En, Hidalgo, Jorge L. S., Tu, Christina, Cahalan, Michael D., Lamb, Bruce T., Landreth, Gary E., Spitale, Robert C., Blurton‐Jones, Mathew, Davtyan, Hayk

“…The P522R variant of PLCG2, expressed by microglia, is associated with reduced risk of Alzheimer's disease (AD). Yet, the impact of this protective mutation on…”
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Examining the effects of the microglial PLCG2 P522R mutation by transplantation of human stem cell‐derived microglia in chimeric AD mice: Molecular and cell biology/stem cells, iPS cells by Claes, Christel, Danhash, Emma, Hasselmann, Jonathan, Chadarevian, Jean Paul, Shabestari, Sepideh Kiani, Lim, Tau En, Tu, Christina, Silva, Jorge, Coburn, Morgan A., Jairaman, Amit, Cahalan, Michael, Blurton‐Jones, Mathew, Davtyan, Hayk

“…Abstract Background Genetic studies have uncovered several Alzheimer’s Disease (AD) risk genes that are highly expressed in microglia, suggesting that immune…”
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Examining the effects of the microglial PLCG2 P522R mutation by transplantation of human stem cell‐derived microglia in chimeric AD mice by Claes, Christel, Danhash, Emma, Hasselmann, Jonathan, Chadarevian, Jean Paul, Shabestari, Sepideh Kiani, Lim, Tau En, Tu, Christina, Silva, Jorge, Coburn, Morgan A., Jairaman, Amit, Cahalan, Michael, Blurton‐Jones, Mathew, Davtyan, Hayk

“…Background Genetic studies have uncovered several Alzheimer’s Disease (AD) risk genes that are highly expressed in microglia, suggesting that immune…”
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Fabrication of a microfluidic device for the compartmentalization of neuron soma and axons by Harris, Joseph, Lee, Hyuna, Vahidi, Behrad, Tu, Christina, Cribbs, David, Jeon, Noo Li, Cotman, Carl

“…In this video, we demonstrate the technique of soft lithography with polydimethyl siloxane (PDMS) which we use to fabricate a microfluidic device for culturing…”
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