Search Results - "Tsykin, Anna"
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The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
Published in Nature cell biology (01-05-2008)“…Epithelial to mesenchymal transition (EMT) facilitates tissue remodelling during embryonic development and is viewed as an essential early step in tumour…”
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Naturally existing isoforms of miR-222 have distinct functions
Published in Nucleic acids research (02-11-2017)“…Deep-sequencing reveals extensive variation in the sequence of endogenously expressed microRNAs (termed 'isomiRs') in human cell lines and tissues, especially…”
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Clinical Utility of a STAT3-Regulated miRNA-200 Family Signature with Prognostic Potential in Early Gastric Cancer
Published in Clinical cancer research (15-03-2018)“…The majority of gastric cancer patients are diagnosed with late-stage disease, for which distinct molecular subtypes have been identified that are potentially…”
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Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion
Published in The EMBO journal (17-09-2014)“…The microRNAs of the miR‐200 family maintain the central characteristics of epithelia and inhibit tumor cell motility and invasiveness. Using the Ago‐HITS‐CLIP…”
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The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking
Published in Science signaling (17-02-2015)“…Factors secreted by tumor cells shape the local microenvironment to promote invasion and metastasis, as well as condition the premetastatic niche to enable…”
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Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin–restricted miRNA antagonists of miR-27
Published in Blood (17-10-2013)“…Cellular junctions are essential to the normal functioning of the endothelium and control angiogenesis, tissue leak, and inflammation. From a screen of micro…”
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Exploring complex miRNA-mRNA interactions with Bayesian networks by splitting-averaging strategy
Published in BMC bioinformatics (10-12-2009)“…microRNAs (miRNAs) regulate target gene expression by controlling their mRNAs post-transcriptionally. Increasing evidence demonstrates that miRNAs play…”
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Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML
Published in Blood (26-11-2009)“…Deregulated cell survival programs are a classic hallmark of cancer. We have previously identified a serine residue (Ser585) in the βc subunit of the…”
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Gene expression analysis of multiple gastrointestinal regions reveals activation of common cell regulatory pathways following cytotoxic chemotherapy
Published in International journal of cancer (15-10-2007)“…Gastrointestinal mucositis involves many changes at the gene level, affecting epithelial/subepithelial interactions and leading to overt damage. The regional…”
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Induction of miR-21 by Retinoic Acid in Estrogen Receptor-positive Breast Carcinoma Cells
Published in The Journal of biological chemistry (01-02-2011)“…Retinoids are promising agents for the treatment/prevention of breast carcinoma. We examined the role of microRNAs in mediating the effects of…”
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11
Nxf and Fbxo33: novel seizure-responsive genes in mice
Published in The European journal of neuroscience (01-10-2004)“…Much is understood about the response of the brain to seizure but little is known in relation to the underlying molecular mechanisms involved. We used…”
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Genetic regulators of myelopoiesis and leukemic signaling identified by gene profiling and linear modeling
Published in Journal of leukocyte biology (01-08-2006)“…Mechanisms controlling the balance between proliferation and self‐renewal versus growth suppression and differentiation during normal and leukemic myelopoiesis…”
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Inferring microRNA-mRNA causal regulatory relationships from expression data
Published in Bioinformatics (15-03-2013)“…microRNAs (miRNAs) are known to play an essential role in the post-transcriptional gene regulation in plants and animals. Currently, several computational…”
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Induction of miR-21 by Retinoic Acid in Estrogen Receptor-positive Breast Carcinoma Cells: BIOLOGICAL CORRELATES AND MOLECULAR TARGETS
Published in The Journal of biological chemistry (04-02-2011)“…Retinoids are promising agents for the treatment/prevention of breast carcinoma. We examined the role of microRNAs in mediating the effects of…”
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Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-beta/bone morphogenic protein signalling
Published in Arthritis research & therapy (01-01-2007)“…Osteoarthritis (OA) is characterized by alterations to subchondral bone as well as articular cartilage. Changes to bone in OA have also been identified at…”
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Identifying functional miRNA–mRNA regulatory modules with correspondence latent dirichlet allocation
Published in Bioinformatics (15-12-2010)“…Motivation: MicroRNAs (miRNAs) are small non-coding RNAs that cause mRNA degradation and translational inhibition. They are important regulators of development…”
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Evidence that Meningeal Mast Cells Can Worsen Stroke Pathology in Mice
Published in The American journal of pathology (01-09-2014)“…Stroke is the leading cause of adult disability and the fourth most common cause of death in the United States. Inflammation is thought to play an important…”
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Inferring microRNA and transcription factor regulatory networks in heterogeneous data
Published in BMC bioinformatics (11-03-2013)“…Transcription factors (TFs) and microRNAs (miRNAs) are primary metazoan gene regulators. Regulatory mechanisms of the two main regulators are of great interest…”
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209: STAT3-driven regulation of microRNAs during gastric inflammation-associated tumourigenesis
Published in Cytokine (Philadelphia, Pa.) (01-11-2014)“…Hyperactivation of the latent transcription factor signal transducer and activator of transcription (STAT)3 is frequently observed in inflammation-associated…”
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