Search Results - "Tsygankova, Oxana M."

A unique role for clathrin light chain A in cell spreading and migration by Tsygankova, Oxana M, Keen, James H

“…Clathrin heavy chain is the structural component of the clathrin triskelion, but unique functions for the two distinct and highly conserved clathrin light…”
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Histone deacetylase is a target of valproic acid-mediated cellular differentiation by GURVICH, Nadia, TSYGANKOVA, Oxana M, MEINKOTH, Judy L, KLEIN, Peter S

“…Valproic acid (VPA), a well-established therapy for seizures and bipolar disorder, has recently been shown to inhibit histone deacetylases (HDACs). Similar to…”
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Tumor Cell Migration and Invasion Are Enhanced by Depletion of Rap1 GTPase-activating Protein (Rap1GAP) by Tsygankova, Oxana M., Wang, Hongbin, Meinkoth, Judy L.

“…The functional significance of the widespread down-regulation of Rap1 GTPase-activating protein (Rap1GAP), a negative regulator of Rap activity, in human…”
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Downregulation of Rap1GAP in Human Tumor Cells Alters Cell/Matrix and Cell/Cell Adhesion by Tsygankova, Oxana M., Ma, Changqing, Tang, Waixing, Korch, Christopher, Feldman, Michael D., Lv, Yu, Brose, Marcia S., Meinkoth, Judy L.

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Protein kinase A and B-Raf mediate extracellular signal-regulated kinase activation by thyrotropin by Vuchak, Lisa A, Tsygankova, Oxana M, Prendergast, Gregory V, Meinkoth, Judy L

“…Thyrotropin (TSH) regulates thyroid cell proliferation and function through cAMP-mediated signaling pathways that activate protein kinase A (PKA) and…”
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Downregulation of Rap1GAP Contributes to Ras Transformation by Tsygankova, Oxana M., Prendergast, Gregory V., Puttaswamy, Kanchan, Wang, Yan, Feldman, Michael D., Wang, Hongbin, Brose, Marcia S., Meinkoth, Judy L.

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Loss of Rap1GAP in Papillary Thyroid Cancer by Nellore, Anoma, Paziana, Karolina, Ma, Changqing, Tsygankova, Oxana M., Wang, Yan, Puttaswamy, Kanchan, Iqbal, Ammarah U., Franks, Susanna R., Lv, Yu, Troxel, Andrea B., Feldman, Michael D., Meinkoth, Judy L., Brose, Marcia S.

“…Context: Rap1 GTPase-activating protein (GAP) regulates the activity of Rap1, a putative oncogene. We previously reported Rap1GAP was highly expressed in…”
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Rap1GAP impairs cell-matrix adhesion in the absence of effects on cell-cell adhesion by Vuchak, Lisa A., Tsygankova, Oxana M., Meinkoth, Judy L.

“…The significance of the widespread downregulation of Rap1GAP in human tumors is unknown. In previous studies we demonstrated that silencing Rap1GAP expression…”
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Ras Triggers Ataxia-telangiectasia-mutated and Rad-3-related Activation and Apoptosis through Sustained Mitogenic Signaling by Fikaris, Aphrothiti J., Lewis, Aurélia E., Abulaiti, Adili, Tsygankova, Oxana M., Meinkoth, Judy L.

“…Genetic evidence indicates that Ras plays a critical role in the initiation and progression of human thyroid tumors. Paradoxically, acute expression of…”
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Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation by Mei, Fang C, Qiao, Jingbo, Tsygankova, Oxana M, Meinkoth, Judy L, Quilliam, Lawrence A, Cheng, Xiaodong

“…The recent discovery of Epac, a novel cAMP receptor protein, opens up a new dimension in studying cAMP-mediated cell signaling. It is conceivable that many of…”
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Ras induces chromosome instability and abrogation of the DNA damage response by ABULAITI, Adili, FIKARIS, Aphrothiti J, TSYGANKOVA, Oxana M, MEINKOTH, Judy L

“…Ras mutations are frequent in thyroid tumors, the most common endocrine malignancy. The ability of Ras to transform thyroid cells is thought to rely on its…”
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Coordinated Regulation of Rap1 and Thyroid Differentiation by Cyclic AMP and Protein Kinase A by Tsygankova, Oxana M., Saavedra, Arturo, Rebhun, John F., Quilliam, Lawrence A., Meinkoth, Judy L.

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TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion by Smirnova, Evgeniya V, Collingwood, Therese S, Bisbal, Catherine, Tsygankova, Oxana M, Bogush, Marina, Meinkoth, Judy L, Henderson, Earl E, Annan, Roland S, Tsygankov, Alexander Y

“…Abstract TULA, a recently identified UBA- and SH3-containing protein, has previously been shown to regulate cell signaling through protein tyrosine kinases. In…”
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Loss of Rap1GAP in Papillary Thyroid Cancer by Nellore, Anoma, Paziana, Karolina, Ma, Changqing, Tsygankova, Oxana M, Wang, Yan, Puttaswamy, Kanchan, Iqbal, Ammarah U, Franks, Susanna R, Lv, Yu, Troxel, Andrea B, Feldman, Michael D, Meinkoth, Judy L, Brose, Marcia S

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Role of cAMP, PKA and Rap1A in thyroid follicular cell survival by SAAVEDRA, Arturo P, TSYGANKOVA, Oxana M, PRENDERGAST, Gregory V, DWORET, Jessica H, CHENG, Guanjun, MEINKOTH, Judy L

“…Cyclic AMP (cAMP) rescues cells from apoptosis stimulated by diverse insults. We examined the role of cAMP as a survival factor, and the signaling pathways…”
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Cyclic AMP activates Ras by TSYGANKOVA, O. M, KUPPERMAN, E, WEI WEN, MEINKOTH, J. L

“…In addition to protein kinase A (PKA), cAMP regulates the activity of cAMP-gated channels and Rap1-specific guanine nucleotide exchange factors. We tested the…”
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Activation of ERK by Ca2+ store depletion in rat liver epithelial cells by Maloney, J A, Tsygankova, O M, Yang, L, Li, Q, Szot, A, Baysal, K, Williamson, J R

“…In rat liver epithelial (WB) cells, Ca2+ pool depletion induced by two independent methods resulted in activation of extracellular signal-regulated protein…”
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Differential Signaling of Cyclic AMP by Mei, Fang C., Qiao, Jingbo, Tsygankova, Oxana M., Meinkoth, Judy L., Quilliam, Lawrence A., Cheng, Xiaodong

“…The recent discovery of Epac, a novel cAMP receptor protein, opens up a new dimension in studying cAMP-mediated cell signaling. It is conceivable that many of…”
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Thyroid-stimulating Hormone/cAMP and Glycogen Synthase Kinase 3β Elicit Opposing Effects on Rap1GAP Stability by Tsygankova, Oxana M., Feshchenko, Elena, Klein, Peter S., Meinkoth, Judy L.

“…Beyond regulating Rap activity, little is known regarding the regulation and function of the Rap GTPase-activating protein Rap1GAP. Tuberin and E6TP1 protein…”
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Thyroid-stimulating Hormone/cAMP and Glycogen Synthase Kinase 3β Elicit Opposing Effects on Rap1GAP Stability by Oxana M. Tsygankova, Elena Feshchenko, Peter S. Klein, Judy L. Meinkoth

“…Beyond regulating Rap activity, little is known regarding the regulation and function of the Rap GTPase-activating protein Rap1GAP. Tuberin and E6TP1 protein…”
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