Epstein‐Barr‐virus‐associated gastric cancer in Russia

The present investigation was carried out to estimate the prevalence of EBV‐associated cases among gastric carcinoma (GC) patients of Russia and the Republics of the former Soviet Union (FSU). With this aim, formalin‐fixed paraffin‐embedded blocks from 206 gastric carcinomas obtained from patients o...

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Bibliographic Details
Published in:	International journal of cancer Vol. 73; no. 6; pp. 786 - 789
Main Authors:	Galetsky, Sergey A., Tsvetnov, Vadim V., Land, Charles E., Afanasieva, Tatiana A., Petrovichev, Nikolay N., Gurtsevitch, Vladimir E., Tokunaga, Masayoshi
Format:	Journal Article
Language:	English
Published:	New York Wiley Subscription Services, Inc., A Wiley Company 10-12-1997
Subjects:	Adenocarcinoma - complications Adenocarcinoma - epidemiology Adenocarcinoma - pathology Adenocarcinoma - virology Adult Aged Aged, 80 and over Biopsy Female Herpesviridae Infections - complications Herpesvirus 4, Human - isolation & purification Humans In Situ Hybridization Male Middle Aged RNA, Viral - analysis Russia - epidemiology Sex Distribution Stomach Neoplasms - complications Stomach Neoplasms - epidemiology Stomach Neoplasms - pathology Stomach Neoplasms - virology Tumor Virus Infections - complications Russia
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Summary:	The present investigation was carried out to estimate the prevalence of EBV‐associated cases among gastric carcinoma (GC) patients of Russia and the Republics of the former Soviet Union (FSU). With this aim, formalin‐fixed paraffin‐embedded blocks from 206 gastric carcinomas obtained from patients of the Cancer Research Center, Moscow, were investigated by EBV‐encoded RNA‐1 (EBER‐1) in situ hybridization applied to paraffin sections. As a result, 18 GC cases (8.7%) revealed uniform EBER‐1 expression restricted to the carcinoma cells. Hybridized signals not detected in non‐neoplastic gastric epithelium. EBV involvement was significantly more frequent among males, especially in tumors of less differentiated types (moderately differentiated tubular adenocarcinomas and poorly differentiated solid adenocarcinomas) and located in the upper stomach (cardia and middle). Most EBV‐positive GCs were characterized by strong lymphoid‐compartment involvement. Our findings concerning the distribution of EBV‐positive GCs by sex, site and hystological type are similar to those in Japan, however, EBV‐positive rate of GC cases in Russia is higher than in Japan and lower than in USA. Int. J. Cancer 73:786–789, 1997. © 1997 Wiley‐Liss, Inc.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0020-7136 1097-0215
DOI:	10.1002/(SICI)1097-0215(19971210)73:6<786::AID-IJC2>3.0.CO;2-Z