Search Results - "Tsvetkov, Evgeny"

Presenilin-1 Knockin Mice Reveal Loss-of-Function Mechanism for Familial Alzheimer’s Disease by Xia, Dan, Watanabe, Hirotaka, Wu, Bei, Lee, Sang Hun, Li, Yan, Tsvetkov, Evgeny, Bolshakov, Vadim Y., Shen, Jie, Kelleher, Raymond J.

“…Presenilins play essential roles in memory formation, synaptic function, and neuronal survival. Mutations in the Presenilin-1 (PSEN1) gene are the major cause…”
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Sex-dependent role for EPHB2 in brain development and autism-associated behavior by Assali, Ahlem, Cho, Jennifer Y, Tsvetkov, Evgeny, Gupta, Abha R, Cowan, Christopher W

“…Autism spectrum disorder (ASD) is characterized by impairments in social communication and interaction and restricted, repetitive behaviors. It is frequently…”
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NPAS4 in the medial prefrontal cortex mediates chronic social defeat stress-induced anhedonia-like behavior and reductions in excitatory synapses by Hughes, Brandon W, Siemsen, Benjamin M, Tsvetkov, Evgeny, Berto, Stefano, Kumar, Jaswinder, Cornbrooks, Rebecca G, Akiki, Rose Marie, Cho, Jennifer Y, Carter, Jordan S, Snyder, Kirsten K, Assali, Ahlem, Scofield, Michael D, Cowan, Christopher W, Taniguchi, Makoto

“…Chronic stress can produce reward system deficits (i.e., anhedonia) and other common symptoms associated with depressive disorders, as well as neural circuit…”
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Modulation of anxiety and fear via distinct intrahippocampal circuits by Engin, Elif, Smith, Kiersten S, Gao, Yudong, Nagy, David, Foster, Rachel A, Tsvetkov, Evgeny, Keist, Ruth, Crestani, Florence, Fritschy, Jean-Marc, Bolshakov, Vadim Y, Hajos, Mihaly, Heldt, Scott A, Rudolph, Uwe

“…Recent findings indicate a high level of specialization at the level of microcircuits and cell populations within brain structures with regards to the control…”
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Norepinephrine enables the induction of associative long-term potentiation at thalamo-amygdala synapses by Tully, Keith, Li, Yan, Tsvetkov, Evgeny, Bolshakov, Vadim Y

“…Emotional arousal, linked to a surge of norepinephrine (NE) in the amygdala, leads to creation of stronger and longer-lasting memories. However, little is…”
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NPAS4 supports cocaine-conditioned cues in rodents by controlling the cell type-specific activation balance in the nucleus accumbens by Hughes, Brandon W., Huebschman, Jessica L., Tsvetkov, Evgeny, Siemsen, Benjamin M., Snyder, Kirsten K., Akiki, Rose Marie, Wood, Daniel J., Penrod, Rachel D., Scofield, Michael D., Berto, Stefano, Taniguchi, Makoto, Cowan, Christopher W.

“…Powerful associations that link drugs of abuse with cues in the drug-paired environment often serve as prepotent relapse triggers. Drug-associated contexts and…”
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Essential Role for TRPC5 in Amygdala Function and Fear-Related Behavior by Riccio, Antonio, Li, Yan, Moon, Jisook, Kim, Kwang-Soo, Smith, Kiersten S., Rudolph, Uwe, Gapon, Svetlana, Yao, Gui Lan, Tsvetkov, Evgeny, Rodig, Scott J., Van't Veer, Ashlee, Meloni, Edward G., Carlezon, William A., Bolshakov, Vadim Y., Clapham, David E.

“…The transient receptor potential channel 5 (TRPC5) is predominantly expressed in the brain where it can form heterotetrameric complexes with TRPC1 and TRPC4…”
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411 Essential role for the neurodevelopmental disorder-linked gene, MEF2C, in inhibitory neuron function and neurotypical behaviors by Cho, Yongjoo (Jennifer), Assali, Ahlem, Tsvetkov, Evgeny, Cowan, Christopher W.

“…OBJECTIVES/GOALS: The MEF2 family of transcription factors regulate gene expression controlling cell differentiation and synapse development. Mutations or…”
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MEF2C Hypofunction in GABAergic Cells Alters Sociability and Prefrontal Cortex Inhibitory Synaptic Transmission in a Sex-Dependent Manner by Cho, Jennifer Y., Rumschlag, Jeffrey A., Tsvetkov, Evgeny, Proper, Divya S., Lang, Hainan, Berto, Stefano, Assali, Ahlem, Cowan, Christopher W.

“…Heterozygous mutations or deletions of MEF2C cause a neurodevelopmental disorder termed MEF2C haploinsufficiency syndrome (MCHS), characterized by autism…”
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stathmin, a Gene Enriched in the Amygdala, Controls Both Learned and Innate Fear by Shumyatsky, Gleb P., Malleret, Gaël, Shin, Ryong-Moon, Takizawa, Shuichi, Tully, Keith, Tsvetkov, Evgeny, Zakharenko, Stanislav S., Joseph, Jamie, Vronskaya, Svetlana, Yin, DeQi, Schubart, Ulrich K., Kandel, Eric R., Bolshakov, Vadim Y.

“…Little is known about the molecular mechanisms of learned and innate fear. We have identified stathmin, an inhibitor of microtubule formation, as highly…”
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Spatiotemporal Asymmetry of Associative Synaptic Plasticity in Fear Conditioning Pathways by Shin, Ryong-Moon, Tsvetkov, Evgeny, Bolshakov, Vadim Y.

“…Input-specific long-term potentiation (LTP) in afferent inputs to the amygdala serves an essential function in the acquisition of fear memory. Factors…”
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Identification of a Signaling Network in Lateral Nucleus of Amygdala Important for Inhibiting Memory Specifically Related to Learned Fear by Shumyatsky, Gleb P., Tsvetkov, Evgeny, Malleret, Gaël, Vronskaya, Svetlana, Hatton, Michael, Hampton, Lori, Battey, James F., Dulac, Catherine, Kandel, Eric R., Bolshakov, Vadim Y.

“…We identified the Grp gene, encoding gastrin-releasing peptide, as being highly expressed both in the lateral nucleus of the amygdala, the nucleus where…”
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Fear Conditioning Occludes LTP-Induced Presynaptic Enhancement of Synaptic Transmission in the Cortical Pathway to the Lateral Amygdala by Tsvetkov, Evgeny, Carlezon, William A., Benes, Francine M., Kandel, Eric R., Bolshakov, Vadim Y.

“…Auditory information critical for fear conditioning, a model of emotional learning, is conveyed to the lateral nucleus of the amygdala via two routes: directly…”
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Glutamate Uptake Determines Pathway Specificity of Long-Term Potentiation in the Neural Circuitry of Fear Conditioning by Tsvetkov, Evgeny, Shin, Ryong-Moon, Bolshakov, Vadim Y

“…Long-term synaptic modifications in afferent inputs to the amygdala underlie fear conditioning in animals. Fear conditioning to a single sensory modality does…”
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12-Lipoxygenase Metabolites of Arachidonic Acid Mediate Metabotropic Glutamate Receptor-Dependent Long-Term Depression at Hippocampal CA3-CA1 Synapses by Feinmark, Steven J, Begum, Roxana, Tsvetkov, Evgeny, Goussakov, Ivan, Funk, Colin D, Siegelbaum, Steven A, Bolshakov, Vadim Y

“…Arachidonic acid metabolites have been proposed as signaling molecules in hippocampal long-term potentiation (LTP) and long-term depression (LTD) for >15…”
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Repeated methamphetamine administration produces cognitive deficits through augmentation of GABAergic synaptic transmission in the prefrontal cortex by Armenta-Resendiz, Monserrat, Assali, Ahlem, Tsvetkov, Evgeny, Cowan, Christopher W, Lavin, Antonieta

“…Methamphetamine (METH) abuse is associated with the emergence of cognitive deficits and hypofrontality, a pathophysiological marker of many neuropsychiatric…”
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MEF2C Hypofunction in Neuronal and Neuroimmune Populations Produces MEF2C Haploinsufficiency Syndrome–like Behaviors in Mice by Harrington, Adam J., Bridges, Catherine M., Berto, Stefano, Blankenship, Kayla, Cho, Jennifer Y., Assali, Ahlem, Siemsen, Benjamin M., Moore, Hannah W., Tsvetkov, Evgeny, Thielking, Acadia, Konopka, Genevieve, Everman, David B., Scofield, Michael D., Skinner, Steven A., Cowan, Christopher W.

“…Microdeletions of the MEF2C gene are linked to a syndromic form of autism termed MEF2C haploinsufficiency syndrome (MCHS). MEF2C hypofunction in neurons is…”
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Epigenetic function during heroin self-administration controls future relapse-associated behavior in a cell type-specific manner by Anderson, Ethan M, Tsvetkov, Evgeny, Galante, Allison, DeVries, Derek, McCue, Lauren M, Wood, Daniel, Barry, Sarah, Berto, Stefano, Lavin, Antonieta, Taniguchi, Makoto, Cowan, Christopher W

“…Opioid use produces enduring associations between drug reinforcement/euphoria and discreet or diffuse cues in the drug-taking environment. These powerful…”
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Tonic Inhibitory Control of Dentate Gyrus Granule Cells by α5-Containing GABAA Receptors Reduces Memory Interference by Engin, Elif, Zarnowska, Ewa D, Benke, Dietmar, Tsvetkov, Evgeny, Sigal, Maksim, Keist, Ruth, Bolshakov, Vadim Y, Pearce, Robert A, Rudolph, Uwe

“…Interference between similar or overlapping memories formed at different times poses an important challenge on the hippocampal declarative memory system…”
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Decreased anxiety-like behavior and Gαq/11-dependent responses in the amygdala of mice lacking TRPC4 channels by Riccio, Antonio, Li, Yan, Tsvetkov, Evgeny, Gapon, Svetlana, Yao, Gui Lan, Smith, Kiersten S, Engin, Elif, Rudolph, Uwe, Bolshakov, Vadim Y, Clapham, David E

“…Transient receptor potential (TRP) channels are abundant in the brain where they regulate transmission of sensory signals. The expression patterns of different…”
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