Search Results - "Tsuzuku, Takuma"

Inhibition of Akt (ser473) Phosphorylation and Rapamycin-Resistant Cell Growth by Knockdown of Mammalian Target of Rapamycin with Small Interfering RNA in Vascular Endothelial Growth Factor Receptor-1-Targeting Vector by Koide, Hiroyuki, Asai, Tomohiro, Furuya, Keiichi, Tsuzuku, Takuma, Kato, Hiroki, Dewa, Takehisa, Nango, Mamoru, Maeda, Noriyuki, Oku, Naoto

“…Previously we developed dicetyl phosphate-tetraethylenepentamine-based polycation liposomes (TEPA-PCL) for use in small interfering RNA (siRNA) therapy. In the…”
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Cell-penetrating peptide-conjugated lipid nanoparticles for siRNA delivery by Asai, Tomohiro, Tsuzuku, Takuma, Takahashi, Shoya, Okamoto, Ayaka, Dewa, Takehisa, Nango, Mamoru, Hyodo, Kenji, Ishihara, Hiroshi, Kikuchi, Hiroshi, Oku, Naoto

“…•Lipid derivatives of cell-penetrating peptides (CPP) were newly synthesized.•Lipid nanoparticles modified with CPP (CPP-LNP) were designed for siRNA…”
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Inhibition of Akt (ser473) Phosphorylation and Rapamycin-Resistant Cell Growth by Knockdown of Mammalian Target of Rapamycin with Small Interfering RNA in Vascular Endothelial Growth Factor Receptor-1-Targeting Vector by Hiroyuki KOIDEa, Tomohiro ASAIa, Keiichi FURUYAa, Takuma TSUZUKUa, Hiroki KATOa, Takehisa DEWAb, Mamoru NANGOb, Noriyuki MAEDAc, Naoto OKUa

“…Previously we developed dicetyl phosphate-tetraethylenepentamine-based polycation liposomes (TEPA-PCL) for use in small interfering RNA (siRNA) therapy. In the…”
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RNA創薬研究におけるポジトロン標識small interfering RNA (siRNA) の positron emission tomography (PET) 体内動態イメージング by 安藤, 英紀, 米永, 憲史, 浅井, 知浩, 畑中, 剣太朗, 小出, 裕之, 都竹, 拓磨, 原田, 典弘, 塚田, 秀夫, 奥, 直人

“…「1. はじめに」small interfering RNA(siRNA)は, 21-23塩基対の2本鎖核酸分子であり, 配列特異的な遺伝子サイレンシングを引き起こすことから, 1,2)遺伝子疾患や難治性疾患を始めとする, 今まで治療が困難であった様々な疾患に対する新規治療薬として, 近年大きな注目を集めている3)…”
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Development of Double-Stranded siRNA Labeling Method Using Positron Emitter and Its In Vivo Trafficking Analyzed by Positron Emission Tomography by Hatanaka, Kentaro, Asai, Tomohiro, Koide, Hiroyuki, Kenjo, Eriya, Tsuzuku, Takuma, Harada, Norihiro, Tsukada, Hideo, Oku, Naoto

“…Pharmacokinetic study of small interfering RNA (siRNA) is an important issue for the development of siRNAs for use as a medicine. For this purpose, a novel and…”
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Dicetyl Phosphate-Tetraethylenepentamine-Based Liposomes for Systemic siRNA Delivery by Asai, Tomohiro, Matsushita, Saori, Kenjo, Eriya, Tsuzuku, Takuma, Yonenaga, Norihito, Koide, Hiroyuki, Hatanaka, Kentaro, Dewa, Takehisa, Nango, Mamoru, Maeda, Noriyuki, Kikuchi, Hiroshi, Oku, Naoto

“…Dicetyl phosphate-tetraethylenepentamine (DCP-TEPA) conjugate was newly synthesized and formed into liposomes for efficient siRNA delivery. Formulation of…”
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In Vivo Imaging of Liposomal Small Interfering RNA (siRNA) Trafficking by Positron Emission Tomography by Ando, Hidenori, Yonenaga, Norihito, Asai, Tomohiro, Hatanaka, Kentaro, Koide, Hiroyuki, Tsuzuku, Takuma, Harada, Norihiro, Tsukada, Hideo, Oku, Naoto

“…In the development of nucleic acid medicines such as small interfering RNA (siRNA) drugs, one problem is how to study the pharmacokinetics and…”
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