Search Results - "Tsuzuku, Junko K"
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Mice lacking a transcriptional corepressor Tob are predisposed to cancer
Published in Genes & development (15-05-2003)“…tob is a member of antiproliferative family genes. Mice lacking tob are prone to spontaneous formation of tumors. The occurrence rate of…”
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2
Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation
Published in Genes & development (01-06-2002)“…tob is a member of an emerging family of genes with antiproliferative function. Tob is rapidly phosphorylated at Ser 152, Ser 154, and Ser 164 by Erk1 and Erk2…”
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3
Alteration of expression or phosphorylation status of tob, a novel tumor suppressor gene product, is an early event in lung cancer
Published in Cancer letters (08-12-2003)“…Tob is a member of the Tob/BTG family, a novel class of anti-proliferative proteins. To investigate the involvement of tob as a tumor suppressor gene in human…”
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4
Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling
Published in Mechanisms of development (01-05-2003)“…Tob inhibits bone morphogenetic protein (BMP) signaling by interacting with receptor-regulated Smads in osteoblasts. Here we provide evidence that Tob also…”
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5
A serine/threonine kinase p90rsk1 phosphorylates the anti‐proliferative protein Tob
Published in Genes to cells : devoted to molecular & cellular mechanisms (01-02-2001)“…Background tob is a member of a gene family with anti‐proliferative function. Over‐expression of Tob in NIH3T3 cells results in the suppression of cell…”
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