Search Results - "Tsutsumi, Shunichirou"

Establishment of cocrystal cocktail grinding method for rational screening of pharmaceutical cocrystals by Yamamoto, Katsuhiko, Tsutsumi, Shunichirou, Ikeda, Yukihiro

“…Cocrystals (CCs) used in the pharmaceutical industry are defined as complex crystals formed by reaction between an API and a cocrystal former (CCF); unlike…”
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High-throughput cocrystal slurry screening by use of in situ Raman microscopy and multi-well plate by Kojima, Takashi, Tsutsumi, Shunichirou, Yamamoto, Katsuhiko, Ikeda, Yukihiro, Moriwaki, Toshiya

“…Cocrystal has attracted much attention in order to improve poor physicochemical properties, since cocrystal former crystallize with the ionic drugs as well as…”
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Characterization and evaluation of miconazole salts and cocrystals for improved physicochemical properties by Tsutsumi, Shunichirou, Iida, Motoo, Tada, Norio, Kojima, Takashi, Ikeda, Yukihiro, Moriwaki, Toshiya, Higashi, Kenjirou, Moribe, Kunikazu, Yamamoto, Keiji

“…Miconazole salts and cocrystals were studied to improve the physicochemical properties of miconazole. Maleate, hemifumarate, and hemisuccinate were prepared…”
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Discovery of a Selective Kinase Inhibitor (TAK-632) Targeting Pan-RAF Inhibition: Design, Synthesis, and Biological Evaluation of C‑7-Substituted 1,3-Benzothiazole Derivatives by Okaniwa, Masanori, Hirose, Masaaki, Arita, Takeo, Yabuki, Masato, Nakamura, Akito, Takagi, Terufumi, Kawamoto, Tomohiro, Uchiyama, Noriko, Sumita, Akihiko, Tsutsumi, Shunichirou, Tottori, Tsuneaki, Inui, Yoshitaka, Sang, Bi-Ching, Yano, Jason, Aertgeerts, Kathleen, Yoshida, Sei, Ishikawa, Tomoyasu

“…With the aim of discovering a selective kinase inhibitor targeting pan-RAF kinase inhibition, we designed novel 1,3-benzothiazole derivatives based on our…”
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Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac‑d‑Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility by Nishizawa, Naoki, Takatsu, Yoshihiro, Kumano, Satoshi, Kiba, Atsushi, Ban, Junko, Tsutsumi, Shunichirou, Matsui, Hisanori, Matsumoto, Shin-ichi, Yamaguchi, Masashi, Ikeda, Yukihiro, Kusaka, Masami, Ohtaki, Tetsuya, Itoh, Fumio, Asami, Taiji

“…Metastin/kisspeptin is an endogenous ligand of KISS1 Receptor (KISS1R). Metastin and KISS1R are suggested to play crucial roles in regulating the secretion of…”
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Design and Synthesis of Novel DFG-Out RAF/Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Inhibitors. 1. Exploration of [5,6]-Fused Bicyclic Scaffolds by Okaniwa, Masanori, Hirose, Masaaki, Imada, Takashi, Ohashi, Tomohiro, Hayashi, Youko, Miyazaki, Tohru, Arita, Takeo, Yabuki, Masato, Kakoi, Kazuyo, Kato, Juran, Takagi, Terufumi, Kawamoto, Tomohiro, Yao, Shuhei, Sumita, Akihiko, Tsutsumi, Shunichirou, Tottori, Tsuneaki, Oki, Hideyuki, Sang, Bi-Ching, Yano, Jason, Aertgeerts, Kathleen, Yoshida, Sei, Ishikawa, Tomoyasu

“…To develop RAF/VEGFR2 inhibitors that bind to the inactive DFG-out conformation, we conducted structure-based drug design using the X-ray cocrystal structures…”
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Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH 2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility by Nishizawa, Naoki, Takatsu, Yoshihiro, Kumano, Satoshi, Kiba, Atsushi, Ban, Junko, Tsutsumi, Shunichirou, Matsui, Hisanori, Matsumoto, Shin-Ichi, Yamaguchi, Masashi, Ikeda, Yukihiro, Kusaka, Masami, Ohtaki, Tetsuya, Itoh, Fumio, Asami, Taiji

“…Metastin/kisspeptin is an endogenous ligand of KISS1 Receptor (KISS1R). Metastin and KISS1R are suggested to play crucial roles in regulating the secretion of…”
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Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives by Hirose, Masaaki, Okaniwa, Masanori, Miyazaki, Tohru, Imada, Takashi, Ohashi, Tomohiro, Tanaka, Yuta, Arita, Takeo, Yabuki, Masato, Kawamoto, Tomohiro, Tsutsumi, Shunichirou, Sumita, Akihiko, Takagi, Terufumi, Sang, Bi-Ching, Yano, Jason, Aertgeerts, Kathleen, Yoshida, Sei, Ishikawa, Tomoyasu

“…Our aim was to discover RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors that possess strong activity and sufficient oral absorption, and…”
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Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 2. Synthesis and characterization of a novel imide-type prodrug for improving oral absorption by Okaniwa, Masanori, Imada, Takashi, Ohashi, Tomohiro, Miyazaki, Tohru, Arita, Takeo, Yabuki, Masato, Sumita, Akihiko, Tsutsumi, Shunichirou, Higashikawa, Keiko, Takagi, Terufumi, Kawamoto, Tomohiro, Inui, Yoshitaka, Yoshida, Sei, Ishikawa, Tomoyasu

“…As an alternative to the previously reported solid dispersion formulation for enhancing the oral absorption of thiazolo[5,4-b]pyridine 1, we investigated novel…”
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Abstract C255: Discovery of TAK-632: A selective kinase inhibitor of pan-RAF with potent antitumor activity against BRAF and NRAS mutant melanomas by Okaniwa, Masanori, Hirose, Masaaki, Arita, Takeo, Yabuki, Masato, Nakamura, Akito, Takagi, Terufumi, Kawamoto, Tomohiro, Uchiyama, Noriko, Sumita, Akihiko, Tsutsumi, Shunichirou, Tottori, Tsuneaki, Inui, Yoshitaka, Sang, Bi-Ching, Yano, Jason, Aertgeerts, Kathleen, Yoshida, Sei, Ishikawa, Tomoyasu

“…Abstract The RAF family kinases play critical roles in cancer progression. Recently, BRAF selective inhibitors have shown significant clinical efficacy in…”
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