Search Results - "Tsutomu Yoshihara"

A prospective interventional trial on the effect of periodontal treatment on Fusobacterium nucleatum abundance in patients with colorectal tumours by Yoshihara, Tsutomu, Kioi, Mitomu, Baba, Junichi, Usuda, Haruki, Kessoku, Takaomi, Iwaki, Michihiro, Takatsu, Tomohiro, Misawa, Noboru, Ashikari, Keiichi, Matsuura, Tetsuya, Fuyuki, Akiko, Ohkubo, Hidenori, Matsumoto, Mitsuharu, Wada, Koichiro, Nakajima, Atsushi, Higurashi, Takuma

“…Fusobacterium nucleatum is associated with the progression of colorectal cancer. Thus, the possibility of preventing colorectal cancer or its progression by…”
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Comparison of the diagnostic performance of NBI, Laser-BLI and LED-BLI: a randomized controlled noninferiority trial by Higurashi, Takuma, Ashikari, Keiichi, Tamura, Shigeki, Takatsu, Tomohiro, Misawa, Noboru, Yoshihara, Tsutomu, Ninomiya, Yuki, Okamoto, Yuki, Taguri, Masataka, Sakamoto, Taku, Oka, Shiro, Nakajima, Atsushi, Tanaka, Shinji, Matsuda, Takahisa

“…Background and aims New image-enhanced endoscopy (IEE), blue Light Imaging (LED-BLI) is launched in USA and Europe, whereas Blue Laser Imaging (Laser-BLI) is…”
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The efficacy of aspirin and metformin combination therapy in patients with rectal aberrant crypt foci: a double-blinded randomized controlled trial by Higurashi, Takuma, Arimoto, Jun, Ashikari, Keiichi, Takatsu, Tomohiro, Misawa, Noboru, Yoshihara, Tsutomu, Matsuura, Tetsuya, Fuyuki, Akiko, Ohkubo, Hidenori, Nakajima, Atsushi

“…The incidence and mortality rates of colorectal cancer (CRC) continue to increase worldwide. Therefore, new preventive strategies are needed to lower the…”
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The protective effect of Bifidobacterium bifidum G9-1 against mucus degradation by Akkermansia muciniphila following small intestine injury caused by a proton pump inhibitor and aspirin by Yoshihara, Tsutomu, Oikawa, Yosuke, Kato, Takayuki, Kessoku, Takaomi, Kobayashi, Takashi, Kato, Shingo, Misawa, Noboru, Ashikari, Keiichi, Fuyuki, Akiko, Ohkubo, Hidenori, Higurashi, Takuma, Tateishi, Yoko, Tanaka, Yoshiki, Nakajima, Shunji, Ohno, Hiroshi, Wada, Koichiro, Nakajima, Atsushi

“…Proton pump inhibitors (PPIs) can alleviate upper gastrointestinal injury but paradoxically exacerbate aspirin (ASA)-induced small intestine injury. In this…”
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Effects of colorectal endoscopic submucosal dissection on postoperative abdominal symptoms: a prospective observational study by Tanabe, Hiroaki, Higurashi, Takuma, Takatsu, Tomohiro, Misawa, Noboru, Yoshihara, Tsutomu, Goto, Shungo, Arimoto, Jun, Ashikari, Keiichi, Taniguchi, Leo, Chiba, Hideyuki, Nakajima, Atsushi

“…Background Endoscopic submucosal dissection (ESD) is an effective procedure to resect large superficial gastrointestinal neoplasms. In gastric ESD, several…”
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The efficacy of a leukotriene receptor antagonist in the treatment of human rectal aberrant crypt foci: a nonrandomized, open-label, controlled trial by Higurashi, Takuma, Arimoto, Jun, Ashikari, Keiichi, Takatsu, Tomohiro, Misawa, Noboru, Yoshihara, Tsutomu, Matsuura, Tetsuya, Fuyuki, Akiko, Ohkubo, Hidenori, Nakajima, Atsushi

“…Leukotriene receptor antagonists (LTRAs) are broadly used for the management of allergic asthma and have recently been indicated to inhibit carcinogenesis and…”
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Clinical impact of evaluation of frailty in endoscopic submucosal dissection for early gastric cancer in elderly patients by Misawa, Noboru, Higurashi, Takuma, Tachikawa, Jun, Tanabe, Hiroaki, Yoshihara, Tsutomu, Ashikari, Keiichi, Kanoshima, Kenji, Fuyuki, Akiko, Ohkubo, Hidenori, Saigusa, Yusuke, Chiba, Hideyuki, Nonaka, Takashi, Kuriyama, Hitoshi, Kobayashi, Noritoshi, Nakajima, Atsushi

“…Aims Endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) is performed safely and effectively in elderly patients; however, whether ESD for…”
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Diagnostic Ability of Ultrasonography Compared with Computed Tomography for Assessing Rectal Feces by Misawa, Noboru, Matsumoto, Masaru, Tsuda, Momoko, Tamura, Shigeki, Yoshihara, Tsutomu, Ashikari, Keiichi, Kessoku, Takaomi, Ohkubo, Hidenori, Higurashi, Takuma, Sanada, Hiromi, Kato, Mototsugu, Nakajima, Atsushi

“…Objectives: Chronic constipation is a common gastrointestinal disorder, and management is crucial. Computed tomography (CT) is useful for evaluating rectal…”
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Strain-level detection of Fusobacterium nucleatum in colorectal cancer specimens by targeting the CRISPR-Cas region by Shimomura, Yumi, Sugi, Yutaka, Kume, Aiko, Tanaka, Wataru, Yoshihara, Tsutomu, Matsuura, Tetsuya, Komiya, Yasuhiko, Ogata, Yusuke, Suda, Wataru, Hattori, Masahira, Higurashi, Takuma, Nakajima, Atsushi, Matsumoto, Mitsuharu

“…is one of the predominant oral bacteria in humans. However, this bacterium is enriched in colorectal cancer (CRC) tissues and may be involved in CRC…”
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Natural History of Chronic Intestinal Pseudo-obstruction and Need for Palliative Care by Tanaka, Kosuke, Ohkubo, Hidenori, Yamamoto, Atsushi, Takahashi, Kota, Kasai, Yuki, Ozaki, Anna, Iwaki, Michihiro, Kobayashi, Takashi, Yoshihara, Tsutomu, Misawa, Noboru, Fuyuki, Akiko, Kato, Shingo, Higurashi, Takuma, Hosono, Kunihiro, Yoneda, Masato, Kurihashi, Takeo, Taguri, Masataka, Nakajima, Atsushi, Gwee, Kok-Ann, Kessoku, Takaomi

“…Natural history of chronic intestinal pseudo-obstruction (CIPO), a rare disease characterized by episodes of non-mechanical obstruction, is unclear in adults…”
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Efficacy of Bifidobacterium bifidum G9-1 in improving quality of life in patients with chronic constipation: a prospective intervention study by FUYUKI, Akiko, HIGURASHI, Takuma, KESSOKU, Takaomi, ASHIKARI, Keiichi, YOSHIHARA, Tsutomu, MISAWA, Noboru, IWAKI, Michihiro, KOBAYASHI, Takashi, OHKUBO, Hidenori, YONEDA, Masato, USUDA, Haruki, WADA, Koichiro, NAKAJIMA, Atsushi

“…Chronic constipation is a functional disorder that decreases a patient’s quality of life (QOL). Because dysbiosis has been associated with constipation, we…”
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Rationale and design of a multicentre, 12-week, randomised, double-blind, placebo-controlled, parallel-group, investigator-initiated trial to investigate the efficacy and safety of elobixibat for chronic constipation by Tanaka, Kosuke, Kessoku, Takaomi, Yamamoto, Atsushi, Takahashi, Kota, Kasai, Yuki, Ozaki, Anna, Iwaki, Michihiro, Kobayashi, Takashi, Yoshihara, Tsutomu, Misawa, Noboru, Kato, Takayuki, Arimoto, Jun, Fuyuki, Akiko, Sakai, Eiji, Higurashi, Takuma, Chiba, Hideyuki, Hosono, Kunihiro, Yoneda, Masato, Iwasaki, Tomoyuki, Kurihashi, Takeo, Nakatogawa, Machiko, Suzuki, Ayao, Taguri, Masataka, Oyamada, Shunsuke, Ariyoshi, Keisuke, Kobayashi, Noritoshi, Ichikawa, Yasushi, Nakajima, Atsushi

“…IntroductionChronic constipation (CC) is a functional disorder that negatively impacts the quality of life of patients. This is a protocol for a multicentre,…”
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Investigation of the Local Recurrence Rate after Colorectal Endoscopic Mucosal Resection: Is Incomplete Polyp Resection Really a Clinically Important Problem? Analysis of the Rationale for the “Resect and Discard” Strategy by Ohkubo, Hidenori, Sato, Takamitsu, Sakai, Eiji, Iida, Hiroshi, Goto, Tohru, Nakajima, Atsushi, Fuyuki, Akiko, Kanoshima, Kenji, Kato, Takayuki, Yoshihara, Tsutomu, Misawa, Noboru, Chiba, Hideyuki, Higrashi, Takuma, Arimoto, Jun, Nonaka, Takashi

“…Background/Aims. The “Resect and Discard” strategy is a potentially useful strategy. At present, only the lesion size and accuracy of diagnosis are cited as…”
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Difference in Defecation Desire Between Patients With and Without Chronic Constipation: A Large-Scale Internet Survey by Ohkubo, Hidenori, Takatsu, Tomohiro, Yoshihara, Tsutomu, Misawa, Noboru, Ashikari, Keiichi, Fuyuki, Akiko, Matsuura, Tetsuya, Higurashi, Takuma, Yamamoto, Kouji, Matsumoto, Heido, Odaka, Takeo, Lembo, Anthony J., Nakajima, Atsushi

“…Defecation desire (DD) is an important physiological component of normal defecation. However, knowledge of DD in the general population and in individuals with…”
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Prior appendectomy and cerebral infarction as potential risk factors for recurrent ischemic colitis: A retrospective observational study by Takatsu, Tomohiro, Misawa, Noboru, Yoshihara, Tsutomu, Ashikari, Keiichi, Kessoku, Takaomi, Ohkubo, Hidenori, Hosono, Kunihiro, Yoneda, Masato, Saito, Satoru, Nakajima, Atsushi, Higurashi, Takuma

“…Background and Aim Ischemic colitis (IC) is a benign disease associated with acute lower gastrointestinal bleeding and frequent recurrence. While several…”
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Comparing the effectiveness of magnesium oxide and naldemedine in preventing opioid-induced constipation: a proof of concept, single institutional, two arm, open-label, phase II, randomized controlled trial: the MAGNET study by Ozaki, Anna, Kessoku, Takaomi, Iwaki, Michihiro, Kobayashi, Takashi, Yoshihara, Tsutomu, Kato, Takayuki, Honda, Yasushi, Ogawa, Yuji, Imajo, Kento, Higurashi, Takuma, Yoneda, Masato, Taguri, Masataka, Yamanaka, Takeharu, Ishiki, Hiroto, Kobayashi, Noritoshi, Saito, Satoru, Ichikawa, Yasushi, Nakajima, Atsushi

“…Patients taking opioids are known to develop opioid-induced constipation (OIC), which reduces their quality of life. The aim of this study is to compare…”
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Exploratory, multicenter, open-label study to evaluate the effects of linaclotide in patients with chronic constipation with an insufficient response to magnesium oxide: A study protocol by Yoshihara, Tsutomu, Kessoku, Takaomi, Takatsu, Tomohiro, Misawa, Noboru, Ashikari, Keiichi, Fuyuki, Akiko, Ohkubo, Hidenori, Higurashi, Takuma, Iwaki, Michihiro, Kurihashi, Takeo, Nakatogawa, Machiko, Yamamoto, Koji, Terada, Izuru, Tanaka, Yusuke, Nakajima, Atsushi

“…Chronic constipation leads to poor quality of life, and treatment remains unsatisfactory for patients. In Japan, magnesium oxide has been commonly used as the…”
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Efficacy and safety of rifaximin in patients with chronic intestinal pseudo-obstruction: a randomized, double-blind, placebo-controlled, phase II—a exploratory trial by OHKUBO, Hidenori, KESSOKU, Takaomi, TANAKA, Kosuke, TAKAHASHI, Kota, TAKATSU, Tomohiro, YOSHIHARA, Tsutomu, MISAWA, Noboru, ASHIKARI, Keiichi, FUYUKI, Akiko, KATO, Shingo, HIGURASHI, Takuma, HOSONO, Kunihiro, YONEDA, Masato, MISUMI, Toshihiro, SHINODA, Satoru, STANGHELLINI, Vincenzo, NAKAJIMA, Atsushi

“…Chronic intestinal pseudo-obstruction (CIPO) is a rare intractable disease with limited treatment options. Small intestinal bacterial overgrowth (SIBO) often…”
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A Handheld Ultrasound Device Can Predict Constipation with Rectal Fecal Retention in a Palliative Care Setting by Yamamoto, Atsushi, Kessoku, Takaomi, Ogata, Tomoki, Jono, Tsumugi, Takahashi, Kota, Tanaka, Kosuke, Suzuki, Ko, Takeda, Yuma, Ozaki, Anna, Kasai, Yuki, Okubo, Naoki, Iwaki, Michihiro, Kobayashi, Takashi, Misawa, Noboru, Yoshihara, Tsutomu, Suzuki, Akihiro, Fuyuki, Akiko, Hasegawa, Sho, Imajo, Kento, Kobayashi, Noritoshi, Matsumoto, Masaru, Tamai, Nao, Sanada, Hiromi, Oyamada, Shunsuke, Ichikawa, Yasushi, Nakajima, Atsushi

“…Although handheld ultrasound devices (HUDs) are commonplace, their ability to diagnose fecal retention (FR) remains unclear. This prospective observational…”
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Case Reports: Transformation of End-Stage Neuroendocrine Tumors With Uncontrollable Liver Metastasis Into a Novel or Additional Functional Phenotype by Kessoku, Takaomi, Kobayashi, Noritoshi, Yoneda, Masato, Kasai, Yuki, Ozaki, Anna, Okubo, Naoki, Iwaki, Michihiro, Kobayashi, Takashi, Yoshihara, Tsutomu, Kurita, Yusuke, Honda, Yasushi, Tokuhisa, Motohiko, Ishiki, Hiroto, Hibiya, Takashi, Fujii, Satoshi, Nakajima, Atsushi, Ichikawa, Yasushi

“…Background: Neuroendocrine tumors (NETs) are rare, but their worldwide incidence is gradually increasing. NETs are generally heterogeneous; however, in rare…”
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