Search Results - "Tsushima, Kensuke"

Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission by Tsushima, Kensuke, Bugger, Heiko, Wende, Adam R, Soto, Jamie, Jenson, Gregory A, Tor, Austin R, McGlauflin, Rose, Kenny, Helena C, Zhang, Yuan, Souvenir, Rhonda, Hu, Xiao X, Sloan, Crystal L, Pereira, Renata O, Lira, Vitor A, Spitzer, Kenneth W, Sharp, Terry L, Shoghi, Kooresh I, Sparagna, Genevieve C, Rog-Zielinska, Eva A, Kohl, Peter, Khalimonchuk, Oleh, Schaffer, Jean E, Abel, E Dale

“…RATIONALE:Cardiac lipotoxicity, characterized by increased uptake, oxidation, and accumulation of lipid intermediates, contributes to cardiac dysfunction in…”
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Enhanced Cardiac Akt/Protein Kinase B Signaling Contributes to Pathological Cardiac Hypertrophy in Part by Impairing Mitochondrial Function via Transcriptional Repression of Mitochondrion-Targeted Nuclear Genes by Wende, Adam R., O'Neill, Brian T., Bugger, Heiko, Riehle, Christian, Tuinei, Joseph, Buchanan, Jonathan, Tsushima, Kensuke, Wang, Li, Caro, Pilar, Guo, Aili, Sloan, Crystal, Kim, Bum Jun, Wang, Xiaohui, Pereira, Renata O., McCrory, Mark A., Nye, Brenna G., Benavides, Gloria A., Darley-Usmar, Victor M., Shioi, Tetsuo, Weimer, Bart C., Abel, E. Dale

“…Sustained Akt activation induces cardiac hypertrophy (LVH), which may lead to heart failure. This study tested the hypothesis that Akt activation contributes…”
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Low-carbohydrate diets containing plant-derived fat but not animal-derived fat ameliorate heart failure by Bujo, Satoshi, Toko, Haruhiro, Ito, Kaoru, Koyama, Satoshi, Ishizuka, Masato, Umei, Masahiko, Yanagisawa-Murakami, Haruka, Guo, Jiaxi, Zhai, Bowen, Zhao, Chunxia, Kishikawa, Risa, Takeda, Norifumi, Tsushima, Kensuke, Ikeda, Yuichi, Takimoto, Eiki, Morita, Hiroyuki, Harada, Mutsuo, Komuro, Issei

“…Cardiovascular disease (CVD) is a global health burden in the world. Although low-carbohydrate diets (LCDs) have beneficial effects on CVD risk, their…”
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Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation by Oishi, Yumiko, Manabe, Ichiro, Tobe, Kazuyuki, Tsushima, Kensuke, Shindo, Takayuki, Fujiu, Katsuhito, Nishimura, Go, Maemura, Koji, Yamauchi, Toshimasa, Kubota, Naoto, Suzuki, Ryo, Kitamura, Toshio, Akira, Shizuo, Kadowaki, Takashi, Nagai, Ryozo

“…Krüppel-like factor 5 (KLF5) is a zinc-finger transcription factor known to play a pivotal role in the pathogenesis of cardiovascular disease. Here, we show…”
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A Cold-Blooded Tiptoer: Nonresolving Cellulitis in an Immunocompromised Patient by Kitaura, Satoshi, Okamoto, Koh, Wakabayashi, Yoshitaka, Okada, Yuta, Okazaki, Aiko, Ikeda, Mahoko, Okugawa, Shu, Fujimoto, Fumie, Bujo, Chie, Minatsuki, Shun, Tsushima, Kensuke, Chikamatsu, Kinuyo, Mitarai, Satoshi, Moriya, Kyoji

“…Abstract Mycobacterium haemophilum is a nontuberculous mycobacteria (NTM) with a predilection for skin and soft tissue infection (SSTI) in the…”
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Connexin-43 Redistribution and Gap Junction Activation During Forced Restraint Protects Against Sudden Arrhythmic Death in Rats by Unuma, Kana, Shintani-Ishida, Kaori, Tsushima, Kensuke, Shimosawa, Tatsuo, Ueyama, Takashi, Kuwahara, Masayoshi, Yoshida, Ken-ichi

“…Background: Connexin-43 (Cx43) expression is reduced or redistributed in heart disease. Restraint or other emotional stressors might cause sudden death in…”
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Restraint Stress Induces Connexin-43 Translocation via α-Adrenoceptors in Rat Heart by Unuma, Kana, Shintani-Ishida, Kaori, Yahagi, Naoki, Tsushima, Kensuke, Shimosawa, Tatsuo, Ueyama, Takashi, Yoshida, Ken-ichi

“…Background: Immobilization (IMO) confers emotional stress in animals and humans. It was recently reported that IMO in rats induced translocation of connexin-43…”
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Temporary Dual-Chamber Pacing Can Stabilize Hemodynamics During Noncardiac Surgery in a Patient With Left Ventricular Hypertrophy and Outflow Obstruction by Kojima, Toshiya, MD, PhD, Imai, Yasushi, MD, PhD, Tsushima, Kensuke, MD, PhD, Uno, Kansei, MD, PhD, Fujiu, Katsuhito, MD, PhD, Iiri, Taroh, MD, PhD, Nishimatsu, Hiroaki, MD, PhD, Suzuki, Takeki, MD, PhD, Sugiyama, Hiroaki, MD, Asada, Kazuo, MD, Nakao, Tomoko, MD, PhD, Yamashita, Hiroshi, MD, PhD, Hirata, Yasunobu, MD, PhD, Nagai, Ryozo, MD, PhD

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A common Ile 823 Met variant of ATP-binding cassette transporter A1 gene ( ABCA1) alters high density lipoprotein cholesterol level in Japanese population by Harada, Tomohiro, Imai, Yasushi, Nojiri, Takefumi, Morita, Hiroyuki, Hayashi, Doubun, Maemura, Koji, Fukino, Keiko, Kawanami, Daiji, Nishimura, Go, Tsushima, Kensuke, Monzen, Koshiro, Yamazaki, Tadashi, Mitsuyama, Satoshi, Shintani, Takahiko, Watanabe, Narimasa, Seto, Kumiko, Sugiyama, Takao, Nakamura, Fumitaka, Ohno, Minoru, Hirata, Yasunobu, Yamazaki, Tsutomu, Nagai, Ryozo

“…Recently, variants in ATP-binding cassette transporter A1 ( ABCA1) were demonstrated to be associated with increased level of high density lipoprotein…”
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Effect of Oral Branched-Chain Amino Acids on Serum Albumin Concentration in Heart Failure Patients with Hypoalbuminemia: Results of a Preliminary Study by Uchino, Yuichi, Watanabe, Masafumi, Takata, Munenori, Amiya, Eisuke, Tsushima, Kensuke, Adachi, Takeshi, Hiroi, Yukio, Funazaki, Toshikazu, Komuro, Issei

“…Background We conducted a randomized, controlled trial to determine whether supplementation with oral branched-chain amino acids (BCAAs) improves serum albumin…”
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IRF3 regulates cardiac fibrosis but not hypertrophy in mice during angiotensin II‐induced hypertension by Tsushima, Kensuke, Osawa, Tomoko, Yanai, Hideyuki, Nakajima, Akira, Takaoka, Akinori, Manabe, Ichiro, Ohba, Yusuke, Imai, Yasushi, Taniguchi, Tadatsugu, Nagai, Ryozo

“…ABSTRACT Hypertension is a typical modern lifestyle‐related disease that is closely associated with the development of cardiovascular disorders. Elevation of…”
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δEF1 Mediates TGF-β Signaling in Vascular Smooth Muscle Cell Differentiation by Nishimura, Go, Manabe, Ichiro, Tsushima, Kensuke, Fujiu, Katsuhito, Oishi, Yumiko, Imai, Yasushi, Maemura, Koji, Miyagishi, Makoto, Higashi, Yujiro, Kondoh, Hisato, Nagai, Ryozo

“…Alteration in the differentiated state of smooth muscle cells (SMCs) is known to be integral to vascular development and the pathogenesis of vascular disease…”
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Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induces Post-Translational Modifications of AKAP121, DRP1 and OPA1 That Promote Mitochondrial Fission by Tsushima, Kensuke, Bugger, Heiko, Wende, Adam R., Soto, Jamie, Jenson, Gregory A., Tor, Austin R., McGlauflin, Rose, Kenny, Helena C., Zhang, Yuan, Souvenir, Rhonda, Hu, Xiao X., Sloan, Crystal L., Pereira, Renata O., Lira, Vitor A, Spitzer, Kenneth W., Sharp, Terry L., Shoghi, Kooresh I., Sparagna, Genevieve C., Rog-Zielinska, Eva A., Kohl, Peter, Khalimonchuk, Oleh, Schaffer, Jean E., Abel, E. Dale

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Abstract 284: Disruption of Nrf2 Promotes Atrial Remodeling and Fibrillation on Aging by Abu-Rmaileh, Naser, Kannan, Sankaranarayanan, Tsushima, Kensuke, Whitehead, Kevin, Abel, E Dale, Marrouche, Nassir F, Namakkal Soorappan, Rajasekaran

“…Abstract only Background: Heart failure is a leading health problem with over 500,000 new cases and 275,000 deaths annually in the United States. Recent…”
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Autopsy report on central pontine myelinolysis triggered by vomiting associated with digoxin intoxication by Unuma, Kana, Harada, Kazuki, Nakajima, Makoto, Eguchi, Hiromi, Tsushima, Kensuke, Ito, Takako, Shintani-Ishida, Kaori, Kojima, Hideaki, Yoshida, Ken-ichi

“…Abstract An 87-year-old male, prescribed digoxin and furosemide for congestive heart failure and Alzheimer disease, had dehydration and anemia due to poor food…”
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Krüppel-like Factor 5 Causes Cartilage Degradation through Transactivation of Matrix Metalloproteinase 9 by Shinoda, Yusuke, Ogata, Naoshi, Higashikawa, Akiro, Manabe, Ichiro, Shindo, Takayuki, Yamada, Takashi, Kugimiya, Fumitaka, Ikeda, Toshiyuki, Kawamura, Naohiro, Kawasaki, Yosuke, Tsushima, Kensuke, Takeda, Norifumi, Nagai, Ryozo, Hoshi, Kazuto, Nakamura, Kozo, Chung, Ung-il, Kawaguchi, Hiroshi

“…Although degradation of cartilage matrix has been suggested to be a rate-limiting step for endochondral ossification during skeletal development, little is…”
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Krüppel-like Factor 5 Causes Cartilage Degradation through Transactivation of Matrix Metalloproteinase 9 by Yusuke Shinoda, Naoshi Ogata, Akiro Higashikawa, Ichiro Manabe, Takayuki Shindo, Takashi Yamada, Fumitaka Kugimiya, Toshiyuki Ikeda, Naohiro Kawamura, Yosuke Kawasaki, Kensuke Tsushima, Norifumi Takeda, Ryozo Nagai, Kazuto Hoshi, Kozo Nakamura, Ung-il Chung, Hiroshi Kawaguchi

“…Although degradation of cartilage matrix has been suggested to be a rate-limiting step for endochondral ossification during skeletal development, little is…”
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Krüppel-like Factor 5 Causes Cartilage Degradation through Transactivation of Matrix Metalloproteinase 9S by Shinoda, Yusuke, Ogata, Naoshi, Higashikawa, Akiro, Manabe, Ichiro, Shindo, Takayuki, Yamada, Takashi, Kugimiya, Fumitaka, Ikeda, Toshiyuki, Kawamura, Naohiro, Kawasaki, Yosuke, Tsushima, Kensuke, Takeda, Norifumi, Nagai, Ryozo, Hoshi, Kazuto, Nakamura, Kozo, Chung, Ung-il, Kawaguchi, Hiroshi

“…Although degradation of cartilage matrix has been suggested to be a rate-limiting step for endochondral ossification during skeletal development, little is…”
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DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation by Nishimura, Go, Manabe, Ichiro, Tsushima, Kensuke, Fujiu, Katsuhito, Oishi, Yumiko, Imai, Yasushi, Maemura, Koji, Miyagishi, Makoto, Higashi, Yujiro, Kondoh, Hisato, Nagai, Ryozo

“…Alteration in the differentiated state of smooth muscle cells (SMCs) is known to be integral to vascular development and the pathogenesis of vascular disease…”
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KRÜPPEL-LIKE FACTOR 5 IS A KEY TRANSCRIPTION FACTOR OF ADIPOCYTE DIFFERENTIATION by Oishi, Yumiko, Manabe, Iciro, Tsushima, Kensuke, Shindo, Takayuki, Yamauchi, Toshimasa, Tobe, Kazuyuki, Kadowaki, Takashi, Nagai, Ryozo

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