Search Results - "Tsuruo, Takashi"

Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal by Tsuruo, Takashi, Naito, Mikihiko, Tomida, Akihiro, Fujita, Naoya, Mashima, Tetsuo, Sakamoto, Hiroshi, Haga, Naomi

“…Recent progress in the development of molecular cancer therapeutics has revealed new types of antitumor drugs, such as Herceptin, Gleevec, and Iressa, as…”
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Modulation of Akt Kinase Activity by Binding to Hsp90 by Sato, Saori, Fujita, Naoya, Tsuruo, Takashi

“…Serine/threonine kinase Akt/PKB is a downstream effector molecule of phosphoinositide 3-kinase and is thought to mediate many biological actions toward…”
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Dofequidar fumarate sensitizes cancer stem‐like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP‐mediated drug export by Katayama, Ryohei, Koike, Sumie, Sato, Shigeo, Sugimoto, Yoshikazu, Tsuruo, Takashi, Fujita, Naoya

“…The ATP‐binding cassette (ABC) transporters (ABC‐T) actively efflux structurally and mechanistically unrelated anticancer drugs from cells. As a consequence,…”
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Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose Deprivation by SAITO, Sakae, FURUNO, Aki, SAKURAI, Junko, SAKAMOTO, Asami, PARK, Hae-Ryong, SHIN-YA, Kazuo, TSURUO, Takashi, TOMIDA, Akihiro

“…Glucose deprivation, a cell condition that occurs in solid tumors, activates the unfolded protein response (UPR). A key feature of the UPR is the transcription…”
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Akt/Protein Kinase B-Dependent Phosphorylation and Inactivation of WEE1Hu Promote Cell Cycle Progression at G2/M Transition by Katayama, Kazuhiro, Fujita, Naoya, Tsuruo, Takashi

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Acyl‐CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide by Mashima, Tetsuo, Sato, Shigeo, Okabe, Sachiko, Miyata, Satoshi, Matsuura, Masaaki, Sugimoto, Yoshikazu, Tsuruo, Takashi, Seimiya, Hiroyuki

“…Lipid metabolism is often elevated in cancer cells and plays an important role in their growth and malignancy. Acyl‐CoA synthetase (ACS), which converts…”
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Small Molecules Destabilize cIAP1 by Activating Auto-ubiquitylation by Sekine, Keiko, Takubo, Kohei, Kikuchi, Ryo, Nishimoto, Michie, Kitagawa, Masayuki, Abe, Fuminori, Nishikawa, Kiyohiro, Tsuruo, Takashi, Naito, Mikihiko

“…Overexpression of an anti-apoptotic protein cIAP1 caused by its genetic amplification was reported in certain cancers, such as hepatocellular carcinoma,…”
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The Platelet Aggregation-Inducing Factor Aggrus/Podoplanin Promotes Pulmonary Metastasis by Kunita, Akiko, Kashima, Takeshi G, Morishita, Yasuyuki, Fukayama, Masashi, Kato, Yukinari, Tsuruo, Takashi, Fujita, Naoya

“…Tumor cell-induced platelet aggregation has been reported to facilitate hematogenous metastasis. Aggrus/podoplanin is a platelet aggregation-inducing factor…”
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Platelet aggregation in the formation of tumor metastasis by TSURUO, Takashi, FUJITA, Naoya

“…Metastasis is the major cause of death from cancer, yet the optimal strategy against it remains uncertain. The pathogenesis of hematogenous metastasis is…”
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Involvement of mitochondrial aggregation in arsenic trioxide (As2O3)‐induced apoptosis in human glioblastoma cells by Haga, Naomi, Fujita, Naoya, Tsuruo, Takashi

“…Arsenic trioxide (As2O3) is effective against acute promyelocytic leukemia and has potential as a novel treatment against malignant solid tumors. As2O3 induces…”
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Phosphorylation of p27Kip1 at Threonine 198 by p90 Ribosomal Protein S6 Kinases Promotes Its Binding to 14-3-3 and Cytoplasmic Localization by Fujita, Naoya, Sato, Saori, Tsuruo, Takashi

“…The cyclin-dependent kinase inhibitor p27Kip1 plays an important role in cell cycle regulation. The cyclin-dependent kinase-inhibitory activity of p27Kip1 is…”
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Freud-1/Aki1, a Novel PDK1-Interacting Protein, Functions as a Scaffold To Activate the PDK1/Akt Pathway in Epidermal Growth Factor Signaling by Nakamura, Akito, Naito, Mikihiko, Tsuruo, Takashi, Fujita, Naoya

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Dephosphorylated hypoxia-inducible factor 1α as a mediator of p53-dependent apoptosis during hypoxia by SUZUKI, Hiroyuki, TOMIDA, Akihiro, TSURUO, Takashi

“…Under hypoxia, HIF-1α binds to aryl hydrocarbon receptor nuclear translocator (ARNT, also called HIF-1β) to activate expression of genes important for cell…”
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Mitochondria regulate the unfolded protein response leading to cancer cell survival under glucose deprivation conditions by Haga, Naomi, Saito, Sakae, Tsukumo, Yoshinori, Sakurai, Junko, Furuno, Aki, Tsuruo, Takashi, Tomida, Akihiro

“…Cancer cells consume large amounts of glucose because of their specific metabolic pathway. However, cancer cells exist in tumor tissue where glucose is…”
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Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine) by Sato, Saori, Fujita, Naoya, Tsuruo, Takashi

“…3-Phosphoinositide-dependent protein kinase-1 (PDK1) plays a central role in activating the AGC subfamily of protein kinases. In particular, PDK1 plays an…”
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Mitochondrial aggregation precedes cytochrome c release from mitochondria during apoptosis by HAGA, Naomi, FUJITA, Naoya, TSURUO, Takashi

“…Mitochondria play a central role in apoptotic signaling pathways. Upon exposure to apoptotic stimuli, mitochondria release cytochrome c to the cytoplasm and…”
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TRF1 Mediates Mitotic Abnormalities Induced by Aurora-A Overexpression by OHISHI, Tomokazu, HIROTA, Toru, TSURUO, Takashi, SEIMIYA, Hiroyuki

“…Aurora-A, a conserved serine-threonine kinase, plays essential roles in mitosis. Aberrant upregulation of Aurora-A perturbs proper mitotic progression and…”
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Rap1 Translates Chemokine Signals to Integrin Activation, Cell Polarization, and Motility across Vascular Endothelium under Flow by Shimonaka, Mika, Katagiri, Koko, Nakayama, Toshinori, Fujita, Naoya, Tsuruo, Takashi, Yoshie, Osamu, Kinashi, Tatsuo

“…Chemokines arrest circulating lymphocytes within the vasculature through the rapid up-regulation of leukocyte integrin adhesive activity, promoting subsequent…”
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Breast cancer resistance protein exports sulfated estrogens but not free estrogens by Imai, Yasuo, Asada, Sakiyo, Tsukahara, Satomi, Ishikawa, Etsuko, Tsuruo, Takashi, Sugimoto, Yoshikazu

“…Breast cancer resistance protein (BCRP), an ATP-binding cassette transporter, confers resistance to a series of anticancer reagents such as mitoxantrone,…”
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PRMT5, a Novel TRAIL Receptor-Binding Protein, Inhibits TRAIL-Induced Apoptosis via Nuclear Factor-κB Activation by Tanaka, Hiroshi, Hoshikawa, Yutaka, Oh-hara, Tomoko, Koike, Sumie, Naito, Mikihiko, Noda, Tetsuo, Arai, Hiroyuki, Tsuruo, Takashi, Fujita, Naoya

“…Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily and has selective antitumor activity. Although…”
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