Search Results - "Tsurumi, Amy"

Global heterochromatin loss: A unifying theory of aging? by Tsurumi, Amy, Li, Willis

“…The aging field is replete with theories. Over the past years, many distinct, yet overlapping mechanisms have been proposed to explain organismal aging. These…”
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Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis by Larson, Kimberly, Yan, Shian-Jang, Tsurumi, Amy, Liu, Jacqueline, Zhou, Jun, Gaur, Kriti, Guo, Dongdong, Eickbush, Thomas H, Li, Willis X

“…Organismal aging is influenced by a multitude of intrinsic and extrinsic factors, and heterochromatin loss has been proposed to be one of the causes of aging…”
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Change in screen time and overuse, and their association with psychological well-being among US-wide school-age children during the COVID-19 pandemic: analysis of the National Survey of Children's Health (NSCH) years 2018-21 by Wu, Helena T, Li, Jiandong, Tsurumi, Amy

“…Previous studies on screen use and children's mental health during the Coronavirus Disease 2019 (COVID-19) pandemic focused only on the timeframe during the…”
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A quorum sensing small volatile molecule promotes antibiotic tolerance in bacteria by Que, Yok-Ai, Hazan, Ronen, Strobel, Benjamin, Maura, Damien, He, Jianxin, Kesarwani, Meenu, Panopoulos, Panagiotis, Tsurumi, Amy, Giddey, Marlyse, Wilhelmy, Julie, Mindrinos, Michael N, Rahme, Laurence G

“…Bacteria can be refractory to antibiotics due to a sub-population of dormant cells, called persisters that are highly tolerant to antibiotic exposure. The low…”
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Canonical and non-canonical JAK/STAT transcriptional targets may be involved in distinct and overlapping cellular processes by Tsurumi, Amy, Zhao, Connie, Li, Willis X

“…The Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway has been well-characterized as a crucial signal transduction cascade that…”
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Unphosphorylated STAT5A stabilizes heterochromatin and suppresses tumor growth by Hu, Xiaoyu, Dutta, Pranabananda, Tsurumi, Amy, Li, Jinghong, Wang, Jingtong, Land, Hartmut, Li, Willis X.

“…Tumor suppressors known to date impede cancer growth by arresting the cell cycle or promoting apoptosis. Here we show that unphosphorylated human STAT5A…”
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Development of a biomarker prediction model for post-trauma multiple organ failure/dysfunction syndrome based on the blood transcriptome by Duran, Ivan, Banerjee, Ankita, Flaherty, Patrick J., Que, Yok-Ai, Ryan, Colleen M., Rahme, Laurence G., Tsurumi, Amy

“…Background Multiple organ failure/dysfunction syndrome (MOF/MODS) is a major cause of mortality and morbidity among severe trauma patients. Current clinical…”
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NF-κBp50 and HDAC1 Interaction Is Implicated in the Host Tolerance to Infection Mediated by the Bacterial Quorum Sensing Signal 2-Aminoacetophenone by Bandyopadhaya, Arunava, Tsurumi, Amy, Rahme, Laurence G

“…Some bacterial quorum sensing (QS) small molecules are important mediators of inter-kingdom signaling and impact host immunity. The QS regulated small volatile…”
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Denver and Marshall scores successfully predict susceptibility to multiple independent infections in trauma patients by Almpani, Marianna, Tsurumi, Amy, Peponis, Thomas, Dhole, Yashoda V, Goodfield, Laura F, Tompkins, Ronald G, Rahme, Laurence G

“…Trauma patients are at risk of repeated hospital-acquired infections, however predictive scores aiming to identify susceptibility to such infections are…”
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Aging mechanisms—A perspective mostly from Drosophila by Tsurumi, Amy, Li, Willis X.

“…A mechanistic understanding of the natural aging process, which is distinct from aging‐related disease mechanisms, is essential for developing interventions to…”
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STAT is an essential activator of the zygotic genome in the early Drosophila embryo by Tsurumi, Amy, Xia, Fan, Li, Jinghong, Larson, Kimberly, LaFrance, Russell, Li, Willis X

“…In many organisms, transcription of the zygotic genome begins during the maternal-to-zygotic transition (MZT), which is characterized by a dramatic increase in…”
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TNF-α/IL-10 Ratio Correlates with Burn Severity and May Serve as a Risk Predictor of Increased Susceptibility to Infections by Tsurumi, Amy, Que, Yok-Ai, Ryan, Colleen M, Tompkins, Ronald G, Rahme, Laurence G

“…Severe burn injury renders patients susceptible to multiple infection episodes; however, identifying specific patient groups at high risk remains challenging…”
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A quorum-sensing signal promotes host tolerance training through HDAC1-mediated epigenetic reprogramming by Bandyopadhaya, Arunava, Tsurumi, Amy, Maura, Damien, Jeffrey, Kate L., Rahme, Laurence G.

“…The mechanisms by which pathogens evade elimination without affecting host fitness are not well understood. For the pathogen Pseudomonas aeruginosa , this…”
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Multi-Biomarker Prediction Models for Multiple Infection Episodes Following Blunt Trauma by Tsurumi, Amy, Flaherty, Patrick J., Que, Yok-Ai, Ryan, Colleen M., Mendoza, April E., Almpani, Marianna, Bandyopadhaya, Arunava, Ogura, Asako, Dhole, Yashoda V., Goodfield, Laura F., Tompkins, Ronald G., Rahme, Laurence G.

“…Severe trauma predisposes patients to multiple independent infection episodes (MIIEs), leading to augmented morbidity and mortality. We developed a method to…”
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The impact of molecular manipulation in residue 114 of human immunodeficiency virus type-1 reverse transcriptase on dNTP substrate binding and viral replication by Van Cor-Hosmer, Sarah K, Daddacha, Waaqo, Kelly, Z, Tsurumi, Amy, Kennedy, Edward M, Kim, Baek

“…Abstract Human immunodeficiency virus type-1 (HIV-1) reverse transcriptase (RT) has a unique tight binding to dNTP substrates. Structural modeling of Ala-114…”
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Raf activation is regulated by tyrosine 510 phosphorylation in Drosophila by Xia, Fan, Li, Jinghong, Hickey, Gavin W, Tsurumi, Amy, Larson, Kimberly, Guo, Dongdong, Yan, Shian-Jang, Silver-Morse, Louis, Li, Willis X

“…The proto-oncoprotein Raf is pivotal for mitogen-activated protein kinase (MAPK) signaling, and its aberrant activation has been implicated in multiple human…”
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Genome-wide transcriptome profiling and development of age prediction models in the human brain by Zarrella, Joseph A, Tsurumi, Amy

“…Aging-related transcriptome changes in various regions of the healthy human brain have been explored in previous works, however, a study to develop prediction…”
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Genome-wide Kdm4 histone demethylase transcriptional regulation in Drosophila by Tsurumi, Amy, Xue, Shuang, Zhang, Lin, Li, Jinghong, Li, Willis X.

“…The histone lysine demethylase 4 (Kdm4/Jmjd2/Jhdm3) family is highly conserved across species and reverses di- and tri-methylation of histone H3 lysine 9…”
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A Preventative Tool for Predicting Blood Stream Infections in Children with Burns by Tsurumi, Amy, Flaherty, Patrick J., Que, Yok-Ai, Ryan, Colleen M., Banerjee, Ankita, Chakraborty, Arijit, Almpani, Marianna, Shankar, Malavika, Goverman, Jeremy, Schulz, John T., Sheridan, Robert L., Friedstat, Jonathan, Hickey, Sean A., Tompkins, Ronald G., Rahme, Laurence G.

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A PREVENTIVE TOOL FOR PREDICTING BLOODSTREAM INFECTIONS IN CHILDREN WITH BURNS by Tsurumi, Amy, Flaherty, Patrick J., Que, Yok-Ai, Ryan, Colleen M., Banerjee, Ankita, Chakraborty, Arijit, Almpani, Marianna, Shankar, Malavika, Goverman, Jeremy, Schulz, John T., Sheridan, Robert L., Friedstat, Jonathan, Hickey, Sean A., Tompkins, Ronald G., Rahme, Laurence G.

“…Introduction: Despite significant advances in pediatric burn care, bloodstream infections (BSIs) remain a compelling challenge during recovery. A personalized…”
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