Search Results - "Tsurudome, Yuya"

Decreased ZO1 expression causes loss of time-dependent tight junction function in the liver of ob/ob mice by Tsurudome, Yuya, Morita, Nao, Horiguchi, Michiko, Ushijima, Kentaro

“…Diabetes patients are at a high risk of developing complications related to angiopathy and disruption of the signal transduction system. The liver is one of…”
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The scaffold protein PDZK1 governs diurnal localization of CNT2 on the plasma membrane in mouse intestinal epithelial cells by Jaballah, Nour, Tsurudome, Yuya, Murakami, Chiho, Matsunaga, Naoya, Ushijima, Kentaro, Koyanagi, Satoru, Ohdo, Shigehiro

“…Abstract Diurnal oscillations in the expression of several types of cell surface transporters have been demonstrated in the intestinal epithelial cells, which…”
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AMFR and DCTN2 genes cause transplantation resistance of adipose-derived mesenchymal stem cells in type 1 diabetes mellitus by Horiguchi, Michiko, Tsurudome, Yuya, Ushijima, Kentaro

“…Type 1 diabetes mellitus (T1DM) is characterized by pancreatic beta cell destruction by autoantibodies and other factors, resulting in insulin secretion…”
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Diurnal expression of MRP4 in bone marrow cells underlies the dosing-time dependent changes in the oxaliplatin-induced myelotoxicity by Kato, Mizuki, Tsurudome, Yuya, Kanemitsu, Takumi, Yasukochi, Sai, Kanado, Yuki, Ogino, Takashi, Matsunaga, Naoya, Koyanagi, Satoru, Ohdo, Shigehiro

“…The expression and function of some xenobiotic transporters varies according to the time of day, causing the dosing time-dependent changes in drug disposition…”
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Estradiol regulation of P-glycoprotein expression in mouse kidney and human tubular epithelial cells, implication for renal clearance of drugs by Kanado, Yuki, Tsurudome, Yuya, Omata, Yuji, Yasukochi, Sai, Kusunose, Naoki, Akamine, Takahiro, Matsunaga, Naoya, Koyanagi, Satoru, Ohdo, Shigehiro

“…P-glycoprotein (P-gp/ABCB1) is an ATP-binding cassette drug efflux transporter expressed in a variety of tissues that affects the pharmacokinetic disposition…”
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Synergistic Antiproliferative Effects of Zoledronic Acid and Fluvastatin on Human Pancreatic Cancer Cell Lines: An in Vitro Study by Elsayed, Mahitab, Kobayashi, Daisuke, Kubota, Toshio, Matsunaga, Naoya, Murata, Ryusei, Yoshizawa, Yuko, Watanabe, Natsuki, Matsuura, Tohru, Tsurudome, Yuya, Ogino, Takashi, Ohdo, Shigehiro, Shimazoe, Takao

“…Bisphosphonates and statins are known to have antitumor activities against different types of cancer cell lines. In the present study, we investigated the…”
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Prostaglandin F2α Affects the Cycle of Clock Gene Expression and Mouse Behavior by Tsurudome, Yuya, Yoshida, Yuya, Hamamura, Kengo, Ogino, Takashi, Yasukochi, Sai, Yasuo, Shinobu, Iwamoto, Ayaka, Yoshihara, Tatsuya, Inazumi, Tomoaki, Tsuchiya, Soken, Takeo, Toru, Nakagata, Naomi, Higuchi, Shigekazu, Sugimoto, Yukihiko, Tsuruta, Akito, Koyanagi, Satoru, Matsunaga, Naoya, Ohdo, Shigehiro

“…Prostaglandins are bioactive compounds, and the activation of their receptors affects the expression of clock genes. However, the prostaglandin F receptor ( )…”
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Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression by Okazaki, Fumiyasu, Matsunaga, Naoya, Okazaki, Hiroyuki, Azuma, Hiroki, Hamamura, Kengo, Tsuruta, Akito, Tsurudome, Yuya, Ogino, Takashi, Hara, Yukinori, Suzuki, Takuya, Hyodo, Kenji, Ishihara, Hiroshi, Kikuchi, Hiroshi, To, Hideto, Aramaki, Hironori, Koyanagi, Satoru, Ohdo, Shigehiro

“…Iron is an important biological catalyst and is critical for DNA synthesis during cell proliferation. Cellular iron uptake is enhanced in tumor cells to…”
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Circadian expression of Glycoprotein 2 (Gp2) gene is controlled by a molecular clock in mouse Peyer's patches by Kusunose, Naoki, Tsuruta, Akito, Hamamura, Kengo, Tsurudome, Yuya, Yoshida, Yuya, Akamine, Takahiro, Matsunaga, Naoya, Koyanagi, Satoru, Ohdo, Shigehiro

“…The expression levels of many cell‐surface proteins vary with the time of day. Glycoprotein 2 (Gp2), specifically expressed on the apical surface of M cells in…”
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Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT by Yamauchi, Tomoaki, Okano, Yumi, Terada, Daishu, Yasukochi, Sai, Tsuruta, Akito, Tsurudome, Yuya, Ushijima, Kentaro, Matsunaga, Naoya, Koyanagi, Satoru, Ohdo, Shigehiro

“…The metabolic reprogramming of amino acids is critical for cancer cell growth and survival. Notably, intracellular accumulation of cysteine is often observed…”
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Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function by Tsurudome, Yuya, Koyanagi, Satoru, Kanemitsu, Takumi, Katamune, Chiharu, Oda, Masayuki, Kanado, Yuki, Kato, Mizuki, Morita, Akari, Tahara, Yu, Matsunaga, Naoya, Shibata, Shigenobu, Ohdo, Shigehiro

“…A number of diverse cell-surface proteins are anchored to the cytoskeleton via scaffold proteins. Na + /H + exchanger regulatory factor-1 (NHERF1), encoded by…”
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Cholecystokinin receptor type A are involved in the circadian rhythm of the mouse retina by Yamakawa, Yusuke, Tsurudome, Yuya, Tamada, Masaki, Tsuchimochi, Yuki, Umeda, Yuya, Yoshida, Yuya, Kobayashi, Daisuke, Kawashiri, Takehiro, Kubota, Toshio, Matsunaga, Naoya, Shimazoe, Takao

“…The retina is the only organ projecting external light to the suprachiasmatic nucleus. Cholecystokinin receptor type A (Cckar/Cckar) is one of the essential…”
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Characterizing the degeneration of nuclear membrane and mitochondria of adipose‐derived mesenchymal stem cells from patients with type II diabetes by Horiguchi, Michiko, Hata, Shinichi, Tsurudome, Yuya, Ushijima, Kentaro

“…Regenerative therapeutic approaches involving the transplantation of stem cells differentiated into insulin‐producing cells are being studied in patients with…”
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Increased SPARC in brain microvessels of ob/ob mice accelerates molecular transport into the brain accompany with albumin by Tsurudome, Yuya, Takahata, Yumi, Morita, Nao, Yamauchi, Soma, Iyoda, Takuya, Horiguchi, Michiko, Ushijima, Kentaro

“…Cytotoxic metabolites originating from the peripheral circulation can induce central nervous system complications associated with diabetes. Since a large…”
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Periodic variation in bile acids controls circadian changes in uric acid via regulation of xanthine oxidase by the orphan nuclear receptor PPARα by Kanemitsu, Takumi, Tsurudome, Yuya, Kusunose, Naoki, Oda, Masayuki, Matsunaga, Naoya, Koyanagi, Satoru, Ohdo, Shigehiro

“…Xanthine oxidase (XOD), also known as xanthine dehydrogenase, is a rate-limiting enzyme in purine nucleotide degradation, which produces uric acid. Uric acid…”
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Oncogenic accumulation of cysteine promotes cancer cell proliferation by regulating the translation of D-type cyclins by Okano, Yumi, Yamauchi, Tomoaki, Fukuzaki, Runa, Tsuruta, Akito, Yoshida, Yuya, Tsurudome, Yuya, Ushijima, Kentaro, Matsunaga, Naoya, Koyanagi, Satoru, Ohdo, Shigehiro

“…Malignant cells exhibit a high demand for amino acids to sustain their abnormal proliferation. Particularly, the intracellular accumulation of cysteine is…”
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Inhibition of Tumor-Derived C-C Motif Chemokine Ligand 2 Expression Attenuates Tactile Allodynia in NCTC 2472 Fibrosarcoma-Inoculated Mice by Taniguchi, Marie, Yasukochi, Sai, Yamakawa, Wakaba, Tsurudome, Yuya, Tsuruta, Akito, Horiguchi, Michiko, Ushijima, Kentaro, Yamashita, Tomohiro, Shindo, Naoya, Ojida, Akio, Matsunaga, Naoya, Koyanagi, Satoru, Ohdo, Shigehiro

“…Neuropathic pain associated with cancers is caused by tumor growth compressing and damaging nerves, which would also be enhanced by inflammatory factors…”
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Suppression of neuropathic pain in the circadian clock-deficient Per2 m/m mice involves up-regulation of endocannabinoid system by Yamakawa, Wakaba, Yasukochi, Sai, Tsurudome, Yuya, Kusunose, Naoki, Yamaguchi, Yuta, Tsuruta, Akito, Matsunaga, Naoya, Ushijima, Kentaro, Koyanagi, Satoru, Ohdo, Shigehiro

“…Neuropathic pain often results from injuries and diseases that affect the somatosensory system. Disruption of the circadian clock has been implicated in the…”
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Suppression of neuropathic pain in the circadian clock-deficient [Per2.sup.m/m] mice involves up-regulation of endocannabinoid system by Yamakawa, Wakaba, Yasukochi, Sai, Tsurudome, Yuya, Kusunose, Naoki, Yamaguchi, Yuta, Tsuruta, Akito, Matsunaga, Naoya, Ushijima, Kentaro, Koyanagi, Satoru, Ohdo, Shigehiro

“…Neuropathic pain often results from injuries and diseases that affect the somatosensory system. Disruption of the circadian clock has been implicated in the…”
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Suppression of neuropathic pain in the circadian clock–deficient Per2m/m mice involves up-regulation of endocannabinoid system by Yamakawa, Wakaba, Yasukochi, Sai, Tsurudome, Yuya, Kusunose, Naoki, Yamaguchi, Yuta, Tsuruta, Akito, Matsunaga, Naoya, Ushijima, Kentaro, Koyanagi, Satoru, Ohdo, Shigehiro

“…Abstract Neuropathic pain often results from injuries and diseases that affect the somatosensory system. Disruption of the circadian clock has been implicated…”
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