Search Results - "Tsuruda, Pamela R"

Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition by Crespo-Garcia, Sergio, Tsuruda, Pamela R., Dejda, Agnieszka, Ryan, Rathi D., Fournier, Frederik, Chaney, Shawnta Y., Pilon, Frederique, Dogan, Taner, Cagnone, Gael, Patel, Priyanka, Buscarlet, Manuel, Dasgupta, Sonali, Girouard, Gabrielle, Rao, Surabhi R., Wilson, Ariel M., O’Brien, Robert, Juneau, Rachel, Guber, Vera, Dubrac, Alexandre, Beausejour, Christian, Armstrong, Scott, Mallette, Frederick A., Yohn, Christopher B., Joyal, Jean-Sebastien, Marquess, Dan, Beltran, Pedro J., Sapieha, Przemyslaw

“…Attenuating pathological angiogenesis in diseases characterized by neovascularization such as diabetic retinopathy has transformed standards of care. Yet…”
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The menthol receptor TRPM8 is the principal detector of environmental cold by Basbaum, Allan I, Tsuruda, Pamela R, Bautista, Diana M, Jordt, Sven-Eric, Stucky, Cheryl L, Julius, David, Glazer, Joshua M, Siemens, Jan

“…Sensory nerve fibres can detect changes in temperature over a remarkably wide range, a process that has been proposed to involve direct activation of…”
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TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents by Bautista, Diana M., Jordt, Sven-Eric, Nikai, Tetsuro, Tsuruda, Pamela R., Read, Andrew J., Poblete, Jeannie, Yamoah, Ebenezer N., Basbaum, Allan I., Julius, David

“…TRPA1 is an excitatory ion channel targeted by pungent irritants from mustard and garlic. TRPA1 has been proposed to function in diverse sensory processes,…”
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Coiled Coils Direct Assembly of a Cold-Activated TRP Channel by Tsuruda, Pamela R., Julius, David, Minor, Daniel L.

“…Transient receptor potential (TRP) channels mediate numerous sensory transduction processes and are thought to function as tetramers. TRP channel physiology is…”
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The star-nosed mole reveals clues to the molecular basis of mammalian touch by Gerhold, Kristin A, Pellegrino, Maurizio, Tsunozaki, Makoto, Morita, Takeshi, Leitch, Duncan B, Tsuruda, Pamela R, Brem, Rachel B, Catania, Kenneth C, Bautista, Diana M

“…Little is known about the molecular mechanisms underlying mammalian touch transduction. To identify novel candidate transducers, we examined the molecular and…”
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Relative contributions of norepinephrine and serotonin transporters to antinociceptive synergy between monoamine reuptake inhibitors and morphine in the rat formalin model by Shen, Fei, Tsuruda, Pamela R, Smith, Jacqueline A M, Obedencio, Glenmar P, Martin, William J

“…Multimodal analgesia is designed to optimize pain relief by coadministering drugs with distinct mechanisms of action or by combining multiple pharmacologies…”
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Prediction of human serotonin and norepinephrine transporter occupancy of duloxetine by pharmacokinetic/pharmacodynamic modeling in the rat by Bourdet, David L, Tsuruda, Pamela R, Obedencio, Glenmar P, Smith, Jacqueline A M

“…Translation of central nervous system occupancy and clinical effect from animal models to humans has remained elusive for many pharmacological targets. The…”
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Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results by Crespo-Garcia, Sergio, Fournier, Frédérik, Diaz-Marin, Roberto, Klier, Sharon, Ragusa, Derek, Masaki, Lauren, Cagnone, Gael, Blot, Guillaume, Hafiane, Ikhlas, Dejda, Agnieszka, Rizk, Rana, Juneau, Rachel, Buscarlet, Manuel, Chorfi, Sarah, Patel, Priyanka, Beltran, Pedro J., Joyal, Jean-Sebastien, Rezende, Flavio A., Hata, Masayuki, Nguyen, Alex, Sullivan, Lynne, Damiano, Jason, Wilson, Ariel M., Mallette, Frédérick A., David, Nathaniel E., Ghosh, Anirvan, Tsuruda, Pamela R., Dananberg, Jamie, Sapieha, Przemyslaw

“…Compromised vascular endothelial barrier function is a salient feature of diabetic complications such as sight-threatening diabetic macular edema (DME)…”
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Influence of ligand binding kinetics on functional inhibition of human recombinant serotonin and norepinephrine transporters by Tsuruda, Pamela R., Yung, Joey, Martin, William J., Chang, Ray, Mai, Ngoc, Smith, Jacqueline A.M.

“…Monoamine reuptake inhibitors treat a wide range of CNS disorders, including depression, obesity, and pain. The in vitro pharmacological properties of these…”
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Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels by Nicoll, Roger A, Tsuruda, Pamela R, Milstein, Aaron D, Bautista, Diana M, Zorn, Julie A, Julius, David, Sigal, Yaron M, Garrison, Jennifer L

“…Sanshool, the compound responsible for the tingling sensations experienced when consuming Szechuan peppercorns, excites sensory neurons through a unique…”
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Neuroanatomical Evidence for Segregation of Nerve Fibers Conveying Light Touch and Pain Sensation in Eimer's Organ of the Mole by Marasco, Paul D., Tsuruda, Pamela R., Bautista, Diana M., Julius, David, Catania, Kenneth C.

“…Talpid moles are small insectivores that live in dark underground tunnels. They depend heavily on touch to navigate and find food. Most species have an array…”
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Fine structure of Eimer's organ in the coast mole (Scapanus orarius) by Marasco, Paul D., Tsuruda, Pamela R., Bautista, Diana M., Catania, Kenneth C.

“…Eimer's organ is a small, densely innervated sensory structure found on the glabrous rhinarium of most talpid moles. This structure consists of an epidermal…”
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Discovery of Axelopran (TD-1211): A Peripherally Restricted μ‑Opioid Receptor Antagonist by Long, Daniel D, Armstrong, Scott R, Beattie, David T, Campbell, Christina B, Church, Timothy J, Colson, Pierre-Jean, Dalziel, Sean M, Jacobsen, John R, Jiang, Lan, Obedencio, Glenmar P, Rapta, Miroslav, Saito, Daisuke, Stergiades, Ioanna, Tsuruda, Pamela R, Van Dyke, Priscilla M, Vickery, Ross G

“…The effects of opioids in the central nervous system (CNS) provide significant benefit in the treatment of pain but can also lead to physical dependence and…”
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The in vitro pharmacological profile of TD-1211, a neutral opioid receptor antagonist by Tsuruda, Pamela R., Vickery, Ross G., Long, Daniel D., Armstrong, Scott R., Beattie, David T.

“…The clinical efficacy of opioid receptor antagonists for the treatment of opioid-induced constipation (OIC) is established. Peripherally selective antagonists…”
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The in vivo pharmacodynamics of the novel opioid receptor antagonist, TD-1211, in models of opioid-induced gastrointestinal and CNS activity by Armstrong, Scott R., Campbell, Christina B., Richardson, Carrie L., Vickery, Ross G., Tsuruda, Pamela R., Long, Daniel D., Hegde, Sharath S., Beattie, David T.

“…The in vivo preclinical pharmacodynamic profile of TD-1211, a selective opioid receptor antagonist currently under development for the treatment of…”
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5-HT 4 receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment by Shen, Fei, Smith, Jacqueline A.M., Chang, Ray, Bourdet, David L., Tsuruda, Pamela R., Obedencio, Glenmar P., Beattie, David T.

“…There remains an urgent need for therapeutic agents that provide improved symptomatic treatment and attenuate disease progression in patients with Alzheimer's…”
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5-HT4 receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment by Shen, Fei, Smith, Jacqueline A.M., Chang, Ray, Bourdet, David L., Tsuruda, Pamela R., Obedencio, Glenmar P., Beattie, David T.

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Cer1p Functions as a Molecular Chaperone in the Endoplasmic Reticulum of Saccharomyces cerevisiae by Hamilton, T. Guy, Norris, Tracy B., Tsuruda, Pamela R., Flynn, Gregory C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Differential effects of monoamine reuptake inhibitors on food intake and energy expenditure in a mouse model of diet‐induced obesity by Martin, William J., Kim, Yoon Yi, Obedencio, Glenmar, Tsuruda, Pamela R, Shen, Fei

“…Dopamine (DA), norepinephrine (NE) and serotonin (5‐HT) modulate feeding behavior and energy homeostasis. Here, we investigated effects of sibutramine (Sib),…”
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5-HT sub(4 receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment) by Shen, Fei, Smith, Jacqueline AM, Chang, Ray, Bourdet, David L, Tsuruda, Pamela R, Obedencio, Glenmar P, Beattie, David T

“…There remains an urgent need for therapeutic agents that provide improved symptomatic treatment and attenuate disease progression in patients with Alzheimer's…”
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