Search Results - "Tsunoda, Toshiyuki"

Death domain–associated protein DAXX regulates noncoding RNA transcription at the centromere through the transcription regulator ZFAT by Ishikura, Shuhei, Yoshida, Kazumasa, Tsunoda, Toshiyuki, Shirasawa, Senji

“…The centromere is an essential chromosomal structure for faithful chromosome segregation during cell division. No protein-coding genes exist at the…”
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ZFAT binds to centromeres to control noncoding RNA transcription through the KAT2B–H4K8ac–BRD4 axis by Ishikura, Shuhei, Nakabayashi, Kazuhiko, Nagai, Masayoshi, Tsunoda, Toshiyuki, Shirasawa, Senji

“…Abstract Centromeres are genomic regions essential for faithful chromosome segregation. Transcription of noncoding RNA (ncRNA) at centromeres is important for…”
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CENP-B promotes the centromeric localization of ZFAT to control transcription of noncoding RNA by Ishikura, Shuhei, Yoshida, Kazumasa, Hashimoto, Sayuri, Nakabayashi, Kazuhiko, Tsunoda, Toshiyuki, Shirasawa, Senji

“…The centromere is a chromosomal locus that is essential for the accurate segregation of chromosomes during cell division. Transcription of noncoding RNA…”
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Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation by Charitou, Theodosia, Srihari, Sriganesh, Lynn, Miriam A., Jarboui, Mohamed-Ali, Fasterius, Erik, Moldovan, Max, Shirasawa, Senji, Tsunoda, Toshiyuki, Ueffing, Marius, Xie, Jianling, Xin, Jin, Wang, Xuemin, Proud, Christopher G., Boldt, Karsten, Al-Khalili Szigyarto, Cristina, Kolch, Walter, Lynn, David J.

“…Background Activating mutations in KRAS frequently occur in colorectal cancer (CRC) patients, leading to resistance to EGFR-targeted therapies. Methods To…”
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The transcriptional regulator Zfat is essential for maintenance and differentiation of the adipocytes by Ishikura, Shuhei, Nagai, Masayoshi, Tsunoda, Toshiyuki, Nishi, Kensuke, Tanaka, Yoko, Koyanagi, Midori, Shirasawa, Senji

“…Adipocytes play crucial roles in the control of whole‐body energy homeostasis. Differentiation and functions of the adipocytes are regulated by various…”
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ROS-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cell line by Nishi, Kensuke, Iwaihara, Yuri, Tsunoda, Toshiyuki, Doi, Keiko, Sakata, Toshifumi, Shirasawa, Senji, Ishikura, Shuhei

“…Excess production of reactive oxygen species (ROS) is known to cause apoptotic cell death. However, the molecular mechanisms whereby ROS induce apoptosis…”
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Cancer Spheroid Proliferation Is Suppressed by a Novel Low-toxicity Compound, Pyra-Metho-Carnil, in a Context-independent Manner by Yoshida, Kazumasa, Nishi, Kensuke, Ishikura, Shuhei, Nakabayashi, Kazuhiko, Yazaki, Ryo, Ohshima, Takashi, Suenaga, Masahiko, Shirasawa, Senji, Tsunoda, Toshiyuki

“…Background/Aim: In a screen of compounds to selectively suppress the growth of cancer spheroids, which contained mutant (mt) KRAS, NPD10621 was discovered and…”
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Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP1 by Kandasamy, Palanivel, Zlobec, Inti, Nydegger, Damian T., Pujol‐Giménez, Jonai, Bhardwaj, Rajesh, Shirasawa, Senji, Tsunoda, Toshiyuki, Hediger, Matthias A.

“…Oncogenic KRAS mutations develop unique metabolic dependencies on nutrients to support tumor metabolism and cell proliferation. In particular, KRAS mutant…”
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A novel compound, ferulic acid-bound resveratrol, induces the tumor suppressor gene p15 and inhibits the three-dimensional proliferation of colorectal cancer cells by Sawata, Yuuga, Matsukawa, Taiji, Doi, Satoshi, Tsunoda, Toshiyuki, Arikawa, Nagisa, Matsunaga, Natsumi, Ohnuki, Koichiro, Shirasawa, Senji, Kotake, Yojiro

“…Resveratrol, a phytoalexin present in grapes and other edible foods, has been reported to have beneficial effects against various diseases including cancer. We…”
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Epipharyngeal Abrasive Therapy (EAT) Reduces the mRNA Expression of Major Proinflammatory Cytokine IL-6 in Chronic Epipharyngitis by Nishi, Kensuke, Yoshimoto, Shohei, Nishi, Soichiro, Nishi, Tatsuro, Nishi, Ryushiro, Tanaka, Takayuki, Tsunoda, Toshiyuki, Imai, Kazuaki, Tanaka, Hiroaki, Hotta, Osamu, Tanaka, Ayaki, Hiromatsu, Kenji, Shirasawa, Senji, Nakagawa, Takashi, Yamano, Takafumi

“…The epipharynx, located behind the nasal cavity, is responsible for upper respiratory tract immunity; however, it is also the site of frequent acute and…”
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Epipharyngeal Abrasive Therapy Down-regulates the Expression of SARS-CoV-2 Entry Factors ACE2 and TMPRSS2 by Nishi, Kensuke, Yoshimoto, Shohei, Nishi, Soichiro, Tsunoda, Toshiyuki, Ohno, Jun, Yoshimura, Michinobu, Hiromatsu, Kenji, Yamano, Takafumi

“…The epipharynx, with its high expression of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) entry factors angiotensin-converting enzyme 2 (ACE2)…”
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ANRIL regulates the proliferation of human colorectal cancer cells in both two- and three-dimensional culture by Naemura, Madoka, Tsunoda, Toshiyuki, Inoue, Yasutoshi, Okamoto, Haruna, Shirasawa, Senji, Kotake, Yojiro

“…ANRIL is a long noncoding RNA transcribed from the INK4 locus that encodes three tumor suppressor genes, p15 , p16, and ARF . Previous studies demonstrated…”
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Acquisition of resistance to vemurafenib leads to interleukin‐10 production through an aberrant activation of Akt in a melanoma cell line by Inozume, Takashi, Tsunoda, Toshiyuki, Morisaki, Takashi, Harada, Kazutoshi, Shirasawa, Seiji, Kawamura, Tatsuyoshi

“…Serine/threonine‐protein kinase B‐Raf (BRAF) inhibitors are very effective in treating melanoma with BRAF mutations. BRAF inhibitors suppress aberrant growth…”
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Epipharyngeal Abrasive Therapy Down-regulates the Expression of Cav1.2: A Key Molecule in Influenza Virus Entry by NISHI, KENSUKE, YOSHIMOTO, SHOHEI, NISHI, SOICHIRO, NISHI, TATSURO, NISHI, RYUSHIRO, TSUNODA, TOSHIYUKI, MORITA, HIROMITSU, TANAKA, HIROAKI, HOTTA, OSAMU, YASUMASU, SUSUMU, HIROMATSU, KENJI, SHIRASAWA, SENJI, NAKAGAWA, TAKASHI, YAMANO, TAKAFUMI

“…BACKGROUND/AIMInfluenza A virus (IAV) infection causes an inflammatory response to the respiratory mucosa. The viral glycoprotein hemagglutinin (HA) binds to…”
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Epipharyngeal Abrasive Therapy (EAT) Has Potential as a Novel Method for Long COVID Treatment by Imai, Kazuaki, Yamano, Takafumi, Nishi, Soichiro, Nishi, Ryushiro, Nishi, Tatsuro, Tanaka, Hiroaki, Tsunoda, Toshiyuki, Yoshimoto, Shohei, Tanaka, Ayaki, Hiromatsu, Kenji, Shirasawa, Senji, Nakagawa, Takashi, Nishi, Kensuke

“…COVID-19 often causes sequelae after initial recovery, referred to collectively as long COVID. Long COVID is considered to be caused by the persistence of…”
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Zfat expression in ZsGreen reporter gene knock‑in mice: Implications for a novel function of Zfat in definitive erythropoiesis by Tsunoda, Toshiyuki, Doi, Keiko, Ishikura, Shuhei, Luo, Hao, Nishi, Kensuke, Matsuzaki, Hiroshi, Koyanagi, Midori, Tanaka, Yoko, Okamura, Tadashi, Shirasawa, Senji

“…Zinc finger and AT‑hook domain containing (Zfat) is a transcriptional regulator harboring an AT‑hook domain and 18 repeats of a C2H2 zinc‑finger motif, which…”
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Inhibition of phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model by Tsunoda, Toshiyuki, Ota, Takeharu, Fujimoto, Takahiro, Doi, Keiko, Tanaka, Yoko, Yoshida, Yasuhiro, Ogawa, Masahiro, Matsuzaki, Hiroshi, Hamabashiri, Masato, Tyson, Darren R, Kuroki, Masahide, Miyamoto, Shingo, Shirasawa, Senji

“…We previously established a three-dimensional (3-D) colonic crypt model using HKe3 cells which are human colorectal cancer (CRC) HCT116 cells with a disruption…”
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KRAS-induced actin-interacting protein regulates inositol 1,4,5-trisphosphate-receptor-mediated calcium release by Fujimoto, Takahiro, Machida, Takashi, Tsunoda, Toshiyuki, Doi, Keiko, Ota, Takeharu, Kuroki, Masahide, Shirasawa, Senji

“…► Reduction of KRAP inhibits IP 3R-mediated Ca 2+ release in the cultured cells. ► KRAP does not affect the releasable Ca 2+ content of intracellular Ca 2+…”
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Effects of Aspergillus fumigatus Conidia on Apoptosis and Proliferation in an In Vitro Model of the Lung Microenvironment by Kushima, Hisako, Tsunoda, Toshiyuki, Matsumoto, Taichi, Kinoshita, Yoshiaki, Izumikawa, Koichi, Shirasawa, Senji, Fujita, Masaki, Ishii, Hiroshi

“…Background/Aim: Aspergillus is often detected in respiratory samples from patients with chronic respiratory diseases, including pulmonary fibrosis, suggesting…”
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Three-dimensionally Specific Inhibition of DNA Repair-Related Genes by Activated KRAS in Colon Crypt Model by Tsunoda, Toshiyuki, Takashima, Yasuo, Fujimoto, Takahiro, Koyanagi, Midori, Yoshida, Yasuhiro, Doi, Keiko, Tanaka, Yoko, Kuroki, Masahide, Sasazuki, Takehiko, Shirasawa, Senji

“…Growth and differentiation of colonic epithelium are regulated in the three-dimensional (3D) physiological architecture, colonic crypt, and deregulation of 3D…”
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