Search Results - "Tsunematsu, Ryosuke"

FBXL21 Regulates Oscillation of the Circadian Clock through Ubiquitination and Stabilization of Cryptochromes by Hirano, Arisa, Yumimoto, Kanae, Tsunematsu, Ryosuke, Matsumoto, Masaki, Oyama, Masaaki, Kozuka-Hata, Hiroko, Nakagawa, Tomoki, Lanjakornsiripan, Darin, Nakayama, Keiichi I., Fukada, Yoshitaka

“…In the mammalian circadian clockwork, CRY1 and CRY2 repressor proteins are regulated by posttranslational modifications for temporally coordinated…”
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FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors by Kitade, Shoko, Onoyama, Ichiro, Kobayashi, Hiroaki, Yagi, Hiroshi, Yoshida, Sachiko, Kato, Masaya, Tsunematsu, Ryosuke, Asanoma, Kazuo, Sonoda, Kenzo, Wake, Norio, Hata, Kenichiro, Nakayama, Keiichi I., Kato, Kiyoko

“…FBXW7 is a ubiquitin ligase that mediates ubiquitylation of oncoproteins, such as c‐Myc, cyclin E, Notch and c‐Jun. FBXW7 is a known tumor‐suppressor gene, and…”
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The Maternally Expressed Gene Tssc3 Regulates the Expression of MASH2 Transcription Factor in Mouse Trophoblast Stem Cells through the AKT-Sp1 Signaling Pathway by Takao, Tomoka, Asanoma, Kazuo, Tsunematsu, Ryosuke, Kato, Kiyoko, Wake, Norio

“…Tssc3 is a maternally expressed/paternally silenced imprinted gene. Recent evidence suggests that the loss of TSSC3 results in placental overgrowth in mice…”
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Attitude changes toward prenatal testing among women with twin pregnancies after the introduction of noninvasive prenatal testing: A single‐center study in Japan by Ogawa, Masanobu, Hasuo, Yasuyuki, Taura, Yumiko, Tsunematsu, Ryosuke, Shikada, Sawako, Matsushita, Yuki, Sato, Kazuo

“…Aim This study aimed to evaluate changes in prenatal testing among women with twin pregnancies before and after the introduction of noninvasive prenatal…”
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Isolation and characterization of human trophoblast side-population (SP) cells in primary villous cytotrophoblasts and HTR-8/SVneo cell line by Takao, Tomoka, Asanoma, Kazuo, Kato, Kiyoko, Fukushima, Kotaro, Tsunematsu, Ryosuke, Hirakawa, Toshio, Matsumura, Sueo, Seki, Hiroyuki, Takeda, Satoru, Wake, Norio

“…Recently, numerous studies have identified that immature cell populations including stem cells and progenitor cells can be found among "side-population" (SP)…”
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Genetic Reevaluation of the Role of F-Box Proteins in Cyclin D1 Degradation by Kanie, Tomoharu, Onoyama, Ichiro, Matsumoto, Akinobu, Yamada, Masanori, Nakatsumi, Hirokazu, Tateishi, Yuki, Yamamura, So, Tsunematsu, Ryosuke, Matsumoto, Masaki, Nakayama, Keiichi I.

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Successful surgical treatment for congenital vaginal agenesis accompanied by functional uterus: A report of two cases by Minami, Chihiro, Tsunematsu, Ryosuke, Hiasa, Kana, Egashira, Katsuko, Kato, Kiyoko

“…We present two cases of congenital vaginal agenesis with functional uterine corpus, manifesting with periodic lower abdominal pain and hematometra in…”
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Mouse Fbw7/Sel-10/Cdc4 Is Required for Notch Degradation during Vascular Development by Tsunematsu, Ryosuke, Nakayama, Keiko, Oike, Yuichi, Nishiyama, Masaaki, Ishida, Noriko, Hatakeyama, Shigetsugu, Bessho, Yasumasa, Kageyama, Ryoichiro, Suda, Toshio, Nakayama, Keiichi I.

“…Mammalian Fbw7 (also known as Sel-10, hCdc4, or hAgo) is the F-box protein component of an SCF (Skp1-Cul1-F-box protein-Rbx1)-type ubiquitin ligase, and the…”
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Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin‐dependent degradation by Fujii, Yo, Yada, Masayoshi, Nishiyama, Masaaki, Kamura, Takumi, Takahashi, Hidehisa, Tsunematsu, Ryosuke, Susaki, Etsuo, Nakagawa, Tadashi, Matsumoto, Akinobu, Nakayama, Keiichi I.

“…Fbxw7 (also known as Sel‐10, hCdc4 or hAgo) is the F‐box protein component of a Skp1–Cul1–F‐box protein (SCF) ubiquitin ligase. Fbxw7 contributes to the…”
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SNP55, a new functional polymorphism of MDM2-P2 promoter, contributes to allele-specific expression of MDM2 in endometrial cancers by Okamoto, Kanako, Tsunematsu, Ryosuke, Tahira, Tomoko, Sonoda, Kenzo, Asanoma, Kazuo, Yagi, Hiroshi, Yoneda, Tomoko, Hayashi, Kenshi, Wake, Norio, Kato, Kiyoko

“…The functional single nucleotide polymorphism (SNP) in the MDM2 promoter region, SNP309, is known to be associated with various diseases, particularly cancer…”
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Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7 by Yada, Masayoshi, Hatakeyama, Shigetsugu, Kamura, Takumi, Nishiyama, Masaaki, Tsunematsu, Ryosuke, Imaki, Hiroyuki, Ishida, Noriko, Okumura, Fumihiko, Nakayama, Keiko, Nakayama, Keiichi I

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Fbxw8 Is Essential for Cul1-Cul7 Complex Formation and for Placental Development by Tsunematsu, Ryosuke, Nishiyama, Masaaki, Kotoshiba, Shuhei, Saiga, Toru, Kamura, Takumi, Nakayama, Keiichi I.

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Cell cycle regulation by F-box protein Fbxw7 by Tsunematsu, Ryosuke

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Early Embryonic Death in Mice Lacking the β-Catenin-Binding Protein Duplin by Nishiyama, Masaaki, Nakayama, Keiko, Tsunematsu, Ryosuke, Tsukiyama, Tadasuke, Kikuchi, Akira, Nakayama, Keiichi I.

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Hypercalcemia Due to Parathyroid Hormone-Related Protein Produced by Primary Ovarian Clear Cell Adenocarcinoma: Case Report by Tsunematsu, Ryosuke, Saito, Toshiaki, Iguchi, Haruo, Fukuda, Toshiro, Tsukamoto, Naoki

“…Objective. Amongovarian carcinomas, clear cell adenocarcinoma is one of the most common histologic subtypes associated with hypercalcemia. However, the…”
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Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis by Onoyama, Ichiro, Tsunematsu, Ryosuke, Matsumoto, Akinobu, Kimura, Taichi, de Alborán, Ignacio Moreno, Nakayama, Keiko, Nakayama, Keiichi I

“…Cell proliferation is strictly controlled during differentiation. In T cell development, the cell cycle is normally arrested at the CD4(+)CD8(+) stage, but the…”
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Phosphorylation‐dependent degradation of c‐Myc is mediated by the F‐box protein Fbw7 by Yada, Masayoshi, Hatakeyama, Shigetsugu, Kamura, Takumi, Nishiyama, Masaaki, Tsunematsu, Ryosuke, Imaki, Hiroyuki, Ishida, Noriko, Okumura, Fumihiko, Nakayama, Keiko, Nakayama, Keiichi I

“…The F‐box protein Skp2 mediates c‐Myc ubiquitylation by binding to the MB2 domain. However, the turnover of c‐Myc is largely dependent on phosphorylation of…”
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Fbxw7 / Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene by Balmain, Allan, Mao, Jian-Hua, Perez-losada, Jesus, Wu, Di, DelRosario, Reyno, Tsunematsu, Ryosuke, Nakayama, Keiichi I, Brown, Ken, Bryson, Sheila

“…The FBXW7/hCDC4 gene encodes a ubiquitin ligase implicated in the control of chromosome stability. Here we identify the mouse Fbxw7 gene as a p53-dependent…”
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Ubiquitylation-mediated regulation of notch signaling by Tsunematsu, Ryosuke

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Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication by Nakayama, K, Nagahama, H, Minamishima, Y A, Matsumoto, M, Nakamichi, I, Kitagawa, K, Shirane, M, Tsunematsu, R, Tsukiyama, T, Ishida, N, Kitagawa, M, Nakayama, K, Hatakeyama, S

“…The ubiquitin-proteasome pathway plays an important role in control of the abundance of cell cycle regulators. Mice lacking Skp2, an F-box protein and…”
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