Activating transcription factor 5 is required for mouse olfactory bulb development via interneuron

Activating transcription factor 5 is required for mouse olfactory bulb development via interneuron

Activating transcription factor 5 (ATF5) is a stress response transcription factor of the cAMP-responsive element-binding/ATF family. Earlier, we reported that ATF5 expression is up-regulated in response to stress, such as amino acid limitation or arsenite exposure. Although ATF5 is widely expressed...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry Vol. 79; no. 7; pp. 1082 - 1089
Main Authors: Umemura, Mariko, Tsunematsu, Kanako, Shimizu, Yusuke I., Nakano, Haruo, Takahashi, Shigeru, Higashiura, Yasutomo, Okabe, Masaru, Takahashi, Yuji
Format: Journal Article
Language:English
Published: England Taylor & Francis 03-07-2015
Oxford University Press
Subjects:
Activating Transcription Factors - genetics
Activating Transcription Factors - metabolism
Aggression
Animals
Animals, Newborn
ATF5
Behavior, Animal
development
Female
Interneurons - pathology
Interneurons - physiology
Male
Mice, Inbred C57BL
Mice, Knockout
olfactory bulb
Olfactory Bulb - embryology
Olfactory Bulb - growth & development
Olfactory Bulb - pathology
Olfactory Nerve - embryology
Olfactory Nerve - pathology
transcription factor
transcription factor
olfactory bulb
development
ATF5
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Summary:Activating transcription factor 5 (ATF5) is a stress response transcription factor of the cAMP-responsive element-binding/ATF family. Earlier, we reported that ATF5 expression is up-regulated in response to stress, such as amino acid limitation or arsenite exposure. Although ATF5 is widely expressed in the brain and the olfactory epithelium, the role of ATF5 is not fully understood. Here, the olfactory bulbs (OBs) of ATF5-deficient mice are smaller than those of wild-type mice. Histological analysis reveals the disturbed laminar structure of the OB, showing the thinner olfactory nerve layer, and a reduced number of interneurons. This is mainly due to the reduced number of bromodeoxyuridine-positive proliferating cells in the subventricular zone, where the interneuron progenitors are formed and migrate to the OBs. Moreover, the olfaction-related aggressive behavior of ATF5-deficient mice is reduced compared to wild-type mice. Our data suggest that ATF5 plays a crucial role in mouse OB development via interneuron. ATF5-deficient mice (ATF5 -/- ) have smaller olfactory bulbs (OBs) showing the thinner olfactory nerve layer and a reduced number of interneurons.
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ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2015.1012042