Frequency and component analysis of contaminants generated in preparation of anticancer agents using closed system drug transfer devices (CSTDs)

Occupational exposure of anticancer agents during their preparation has been recognized as a serious hazard. Closed system drug transfer devices (CSTDs) enable “safe” preparation of agents for medical personnel and ensure a safe hospital environment. However, artificial particles of infusion materia...

Full description

Saved in:

Bibliographic Details
Published in:	Scientific reports Vol. 12; no. 1; p. 139
Main Authors:	Sumikawa, Satomi, Yakushijin, Yoshihiro, Aogi, Kenjiro, Yano, Takuya, Hiroki, Hashimoto, Tsukui, Chiyuki, Noguchi, Tadashi, Shiraishi, Taro, Horikawa, Yasuhiro, Yasuoka, Yasuo, Tanaka, Akihiro, Hidaka, Noriaki, Tanaka, Mamoru
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 07-01-2022 Nature Publishing Group Nature Portfolio
Subjects:	631/67 631/67/1059 Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - analysis Antineoplastic Agents - adverse effects Antineoplastic Agents - analysis Antitumor agents Cancer Chemical Safety - instrumentation Contaminants Contamination Cytotoxicity Drug Compounding Equipment Contamination - prevention & control Hazardous Substances - adverse effects Hazardous Substances - analysis Health Personnel Hospitals Humanities and Social Sciences Humans Injections Japan Medical personnel Monoclonal antibodies multidisciplinary Occupational exposure Occupational Exposure - analysis Occupational Exposure - prevention & control Occupational Health Patient Safety Protective Devices Risk Assessment Science Science (multidisciplinary) Japan
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Occupational exposure of anticancer agents during their preparation has been recognized as a serious hazard. Closed system drug transfer devices (CSTDs) enable “safe” preparation of agents for medical personnel and ensure a safe hospital environment. However, artificial particles of infusion materials have been reported during CSTD use. Here, the incidence of insoluble fine particles during preparation of anticancer agents using CSTDs was examined. Visible insoluble fine particles were found in 465 (9.4%) of 4948 treatment cases at Ehime University Hospital with CSTD use. Contaminants occurred more frequently during preparation of monoclonal antibodies than cytotoxic anticancer agents (19.4% vs. 4.1%, respectively, P < 0.01). A similar survey was conducted at nine hospitals to investigate the incidence of insoluble fine particles with or without CSTDs. Insoluble fine particles were detected in 113 (15.4%) of 732 treatment cases during preparation of monoclonal antibodies with CSTD use. In contrast, the occurrence of insoluble fine particles without CSTDs was found in only 3 (0.073%) of 4113 treatment cases. Contamination with CSTDs might cause harmful effects on patients during cancer therapy. We strongly recommend the use of in-line filters combined with infusion routes after CSTD use to avoid contamination-associated adverse events.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-021-03780-0