Search Results - "Tsukahara, Shigehiro"

Androgen receptor mutations for precision medicine in prostate cancer by Shiota, Masaki, Akamatsu, Shusuke, Tsukahara, Shigehiro, Nagakawa, Shohei, Matsumoto, Takashi, Eto, Masatoshi

“…Hormonal therapies including androgen deprivation therapy and androgen receptor (AR) pathway inhibitors such as abiraterone and enzalutamide have been widely…”
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Extracellular vesicles expressing CEACAM proteins in the urine of bladder cancer patients by Igami, Ko, Uchiumi, Takeshi, Shiota, Masaki, Ueda, Saori, Tsukahara, Shigehiro, Akimoto, Masaru, Eto, Masatoshi, Kang, Dongchon

“…Early detection and long‐term monitoring are important for urothelial carcinoma of the bladder (UCB). Urine cytology and existing markers have insufficient…”
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Mitochondrial dysfunction-induced high hCG associated with development of fetal growth restriction and pre-eclampsia with fetal growth restriction by Kiyokoba, Ryo, Uchiumi, Takeshi, Yagi, Mikako, Toshima, Takahiro, Tsukahara, Shigehiro, Fujita, Yasuyuki, Kato, Kiyoko, Kang, Dongchon

“…Fetal growth restriction (FGR) and pre-eclampsia with fetal growth restriction (PE/FGR) are high-risk perinatal diseases that may involve high levels of human…”
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Cancer genomic profiling identified dihydropyrimidine dehydrogenase deficiency in bladder cancer promotes sensitivity to gemcitabine by Tsukahara, Shigehiro, Shiota, Masaki, Takamatsu, Dai, Nagakawa, Shohei, Matsumoto, Takashi, Kiyokoba, Ryo, Yagi, Mikako, Setoyama, Daiki, Noda, Nozomi, Matsumoto, Shinya, Hayashi, Tetsutaro, Contreras-Sanz, Alberto, Black, Peter C., Inokuchi, Junichi, Kohashi, Kenichi, Oda, Yoshinao, Uchiumi, Takeshi, Eto, Masatoshi, Kang, Dongchon

“…Chemotherapy is a standard therapy for muscle-invasive bladder cancer (MIBC). However, genomic alterations associated with chemotherapy sensitivity in MIBC…”
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Fusion‐targeted biopsy significantly improves prostate cancer detection in biopsy‐naïve men by Blas, Leandro, Shiota, Masaki, Tsukahara, Shigehiro, Goto, Shunsuke, Kinoshita, Fumio, Matsumoto, Takashi, Monji, Keisuke, Kashiwagi, Eiji, Inokuchi, Junichi, Eto, Masatoshi

“…Objective The precise diagnosis of prostate cancer (PC) is crucial to avoid underdiagnosis, overdiagnosis, and overtreatment. We aimed to compare clinically…”
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Genomic characteristics revealed by targeted exon sequencing of testicular germ cell tumors in Japanese men by Matsumoto, Takashi, Shiota, Masaki, Uchiumi, Takeshi, Ueda, Shohei, Tsukahara, Shigehiro, Toshima, Takahiro, Matsumoto, Shinya, Noda, Nozomi, Eto, Masatoshi, Kang, Dongchon

“…Objective To investigate the somatic mutation profiles of testicular germ cell tumors in Japanese men. Methods We analyzed the somatic missense mutation…”
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Validation of models predicting lymph node involvement probability in patients with prostate cancer by Blas, Leandro, Shiota, Masaki, Nagakawa, Shohei, Tsukahara, Shigehiro, Matsumoto, Takashi, Monji, Keisuke, Kashiwagi, Eiji, Takeuchi, Ario, Inokuchi, Junichi, Eto, Masatoshi

“…Objectives There are many models to predict lymph node involvement in patients with prostate cancer. We aimed to externally validate several models in a…”
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Gene amplification of YB‐1 in castration‐resistant prostate cancer in association with aberrant androgen receptor expression by Shiota, Masaki, Sekino, Yohei, Tsukahara, Shigehiro, Abe, Tatsuro, Kinoshita, Fumio, Imada, Kenjiro, Ueda, Shohei, Ushijima, Miho, Nagakawa, Shohei, Matsumoto, Takashi, Kashiwagi, Eiji, Takeuchi, Ario, Inokuchi, Junichi, Uchiumi, Takeshi, Oda, Yoshinao, Eto, Masatoshi

“…Although Y‐box binding protein‐1 (YB‐1) is known to be overexpressed in prostate cancer, especially castration‐resistant prostate cancer (CRPC), the mechanism…”
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The impact of genetic polymorphism on CYP19A1 in androgen-deprivation therapy among Japanese men by Shiota, Masaki, Fujimoto, Naohiro, Tsukahara, Shigehiro, Ushijima, Miho, Takeuchi, Ario, Kashiwagi, Eiji, Inokuchi, Junichi, Tatsugami, Katsunori, Uchiumi, Takeshi, Eto, Masatoshi

“…Purpose Inadequate suppression of testosterone during androgen-deprivation therapy impairs its efficacy. This study investigated the significance of genetic…”
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Differential Impact of TGFB1 Variation by Metastatic Status in Androgen-Deprivation Therapy for Prostate Cancer by Shiota, Masaki, Fujimoto, Naohiro, Matsumoto, Takashi, Tsukahara, Shigehiro, Nagakawa, Shohei, Ueda, Shohei, Ushijima, Miho, Kashiwagi, Eiji, Takeuchi, Ario, Inokuchi, Junichi, Uchiumi, Takeshi, Eto, Masatoshi

“…Transforming growth factor-β1 (TGF-β1) plays a dual role in cancer, acting as a tumor suppressor in the early stage of cancer development and as a tumor…”
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The impact of single-nucleotide polymorphisms on intravesical recurrence after bacillus Calmette–Guérin therapy for non-muscle invasive bladder cancer in a genome-wide association study by Nagakawa, Shohei, Shiota, Masaki, Fujimoto, Naohiro, Yamamoto, Yoshiaki, Blas, Leandro, Tsukahara, Shigehiro, Matsumoto, Takashi, Kashiwagi, Eiji, Takeuchi, Ario, Inokuchi, Junichi, Uchiumi, Takeshi, Matsuyama, Hideyasu, Eto, Masatoshi

“…•Genome-wide association study (GWAS) identified 12 candidate single-nucleotide polymorphisms (SNPs) which may predictive for intravesical recurrence after…”
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Validation of user-friendly models predicting extracapsular extension in prostate cancer patients by Blas, Leandro, Shiota, Masaki, Nagakawa, Shohei, Tsukahara, Shigehiro, Matsumoto, Takashi, Lee, Ken, Monji, Keisuke, Kashiwagi, Eiji, Inokuchi, Junichi, Eto, Masatoshi

“…Objective: There are many models to predict extracapsular extension (ECE) in patients with prostate cancer. We aimed to externally validate several models in a…”
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Impact of proton pump inhibitors on the efficacy of androgen receptor signaling inhibitors in metastatic castration‐resistant prostate cancer patients by Tanegashima, Tokiyoshi, Shiota, Masaki, Tsukahara, Shigehiro, Mutaguch, Jun, Goto, Shunsuke, Kobayashi, Satoshi, Matsumoto, Takashi, Eto, Masatoshi

“…Background Proton pump inhibitors (PPIs) are widely used due to their affordability and minimal severe side effects. However, their influence on the efficacy…”
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Importance of 3β-hydroxysteroid dehydrogenases and their clinical use in prostate cancer by Shiota, Masaki, Endo, Satoshi, Tsukahara, Shigehiro, Tanegashima, Tokiyoshi, Kobayashi, Satoshi, Matsumoto, Takashi, Eto, Masatoshi

“…Androgen receptor signaling is crucial for the development of treatment resistance in prostate cancer. Among steroidogenic enzymes, 3β-hydroxysteroid…”
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Oxidative stress in peroxisomes induced by androgen receptor inhibition through peroxisome proliferator–activated receptor promotes enzalutamide resistance in prostate cancer by Shiota, Masaki, Ushijima, Miho, Tsukahara, Shigehiro, Nagakawa, Shohei, Okada, Tatsunori, Tanegashima, Tokiyoshi, Kobayashi, Satoshi, Matsumoto, Takashi, Eto, Masatoshi

“…Androgen receptor (AR)-targeting therapy induces oxidative stress in prostate cancer. However, the mechanism of oxidative stress induction by AR-targeting…”
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PD02-09 ctDNA DETECTION OF NON-CORDING MUTATION IN PLEKHS1 BY DIGITAL PCR ENABLES EARLY PREDICTION OF RECURRENCE IN MUSCLE-INVASIVE BLADDER CANCER by Matsumoto, Takashi, Shigehiro, Tsukahara, Shiota, Masaki, Goto, Shunsuke, Mutaguchi, Jun, Monji, Keisuke, Inokuchi, Junichi, Kodama, Keisuke, Eto, Masatoshi

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Independent validation of genetic risk model to progression after intravesical bacillus Calmette‐Guérin therapy for non‐muscle invasive bladder cancer by Shiota, Masaki, Nagakawa, Shohei, Tsukahara, Shigehiro, Matsumoto, Takashi, Tanegashima, Tokiyoshi, Eto, Masatoshi

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Optimization of Extended Pelvic Lymph Node Dissection Side for Prostate Cancer by Shiota, Masaki, Shimbo, Masaki, Tsukahara, Shigehiro, Tanegashima, Tokiyoshi, Mutaguchi, Jun, Goto, Shunsuke, Kobayashi, Satoshi, Matsumoto, Takashi, Hattori, Kazunori, Endo, Fumiyasu, Eto, Masatoshi

“…Background This study aimed to show the association between tumor location and laterality of positive lymph nodes by evaluating biopsy and magnetic resonance…”
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NR5A2/HSD3B1 pathway promotes cellular resistance to second-generation antiandrogen darolutamide by Shiota, Masaki, Ushijima, Miho, Tsukahara, Shigehiro, Nagakawa, Shohei, Blas, Leandro, Takamatsu, Dai, Kobayashi, Satoshi, Matsumoto, Takashi, Inokuchi, Junichi, Eto, Masatoshi

“…This study investigated cellular mechanisms in steroidogenesis responsible for treatment resistance to the novel antiandrogen agent darolutamide in prostate…”
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Adverse Events of Cabozantinib Plus Nivolumab Versus Ipilimumab Plus Nivolumab by Blas, Leandro, Shiota, Masaki, Tsukahara, Shigehiro, Nagakawa, Shohei, Matsumoto, Takashi, Eto, Masatoshi

“…Recently, many agents and combinations for metastatic and advanced renal cell carcinoma have been approved. This study aims to highlight the comprehensive…”
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