Search Results - "Tsujimoto, Ikuko"
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Wnt5a promotes cancer cell invasion and proliferation by receptor-mediated endocytosis-dependent and -independent mechanisms, respectively
Published in Scientific reports (27-01-2015)“…Wnt5a activates the Wnt/β-catenin-independent pathway and its overexpression is associated with tumor aggressiveness enhancing invasive activity. For this…”
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Critical Role of Factor XIII in the Initial Stages of Carbon Tetrachloride–Induced Adult Liver Remodeling
Published in The American journal of pathology (01-12-2011)“…The transglutaminase-mediated, covalent cross-linking of proteins is an essential step in tissue remodeling after injury. This process provides tissues with…”
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Tubulointerstitial Nephritis Caused by Chronic Lymphocytic Leukemia
Published in Internal Medicine (01-01-2015)Get full text
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Targeted Deletion of Apoptosis Signal-Regulating Kinase 1 Attenuates Left Ventricular Remodeling
Published in Proceedings of the National Academy of Sciences - PNAS (23-12-2003)“…Left ventricular remodeling that occurs after myocardial infarction (MI) and pressure overload is generally accepted as a determinant of the clinical course of…”
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Depletion of CSN5 inhibits Ras-mediated tumorigenesis by inducing premature senescence in p53-null cells
Published in FEBS letters (14-12-2012)“…► Depletion of CSN5 prevents formation of tumors by Ras transformed cells. ► Depletion of CSN5 suppresses cell proliferation, and induces premature senescence…”
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Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis
Published in The Journal of clinical investigation (01-10-2004)“…The Raf/MEK/extracellular signal-regulated kinase (ERK) signaling pathway regulates diverse cellular processes such as proliferation, differentiation, and…”
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Apoptosis Signal-Regulating Kinase 1/p38 Signaling Pathway Negatively Regulates Physiological Hypertrophy
Published in Circulation (New York, N.Y.) (29-01-2008)“…Mechanical stress on the heart can lead to crucially different outcomes. Physiological stimuli such as exercise cause adaptive cardiac hypertrophy,…”
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Apicobasal secretion of Wnt11 and Wnt3a in polarized epithelial cells is regulated by distinct mechanisms
Published in Journal of cell science (01-01-2013)“…Wnts are glycan- and lipid-modified morphogens that are important for cellular responses, but how Wnt is secreted in polarized epithelial cells remains…”
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A Hollenhorst Plaque in Cholesterol Crystal Embolism
Published in Internal Medicine (01-01-2012)Get full text
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A Case of Emphysematous Cystitis
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The Antioxidant Edaravone Attenuates Pressure Overload–Induced Left Ventricular Hypertrophy
Published in Hypertension (Dallas, Tex. 1979) (01-05-2005)“…The free radical scavenger 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone) is used to treat patients with ischemic brain damage. We and others reported…”
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Temporal Artery Involvement in Microscopic Polyangitis
Published in Internal Medicine (2011)“…An 81-year-old man was hospitalized because of fever and pain in the temporal region. Temporal artery biopsy revealed temporal arteritis; steroid therapy was…”
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Pressure overload induces cardiac dysfunction and dilation in signal transducer and activator of transcription 6-deficient mice
Published in Circulation (New York, N.Y.) (26-10-2004)“…Signal transducer and activator of transcription (STAT) proteins constitute a family of transcription factors that mediate many cytokine-induced responses…”
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The apical and basolateral secretion of Wnt11 and Wnt3a in polarized epithelial cells is regulated by different mechanisms
Published in Journal of cell science (01-07-2013)“…Wnts are glycan- and lipid-modified morphogens that are important for cellular responses, but how Wnts are secreted in polarized epithelial cells remains…”
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A Fibronectin-Independent Mechanism of Collagen Fibrillogenesis in Adult Liver Remodeling
Published in Gastroenterology (New York, N.Y. 1943) (01-05-2011)“…Background & Aims Fibrosis is an abnormal extension of the wound healing process that follows tissue damage; it is involved in pathogenesis in a variety of…”
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CaMKII activates ASK1 and NF-κB to induce cardiomyocyte hypertrophy
Published in Biochemical and biophysical research communications (04-02-2005)“…Ca 2+/calmodulin-dependent protein kinase (CaMK) is an important downstream target of Ca 2+ in the hypertrophic signaling pathways. We previously showed that…”
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Ca(2+)-sensitive tyrosine kinase Pyk2/CAK beta-dependent signaling is essential for G-protein-coupled receptor agonist-induced hypertrophy
Published in Journal of molecular and cellular cardiology (01-06-2004)“…G-protein-coupled receptor agonists including endothelin-1 (ET-1) and phenylephrine (PE) induce hypertrophy in neonatal ventricular cardiomyocytes. Others and…”
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CaMKII activates ASK1 and NF-kappaB to induce cardiomyocyte hypertrophy
Published in Biochemical and biophysical research communications (04-02-2005)“…Ca2+/calmodulin-dependent protein kinase (CaMK) is an important downstream target of Ca2+ in the hypertrophic signaling pathways. We previously showed that the…”
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Ca 2+-sensitive tyrosine kinase Pyk2/CAK β-dependent signaling is essential for G-protein-coupled receptor agonist-induced hypertrophy
Published in Journal of molecular and cellular cardiology (2004)“…G-protein-coupled receptor agonists including endothelin-1 (ET-1) and phenylephrine (PE) induce hypertrophy in neonatal ventricular cardiomyocytes. Others and…”
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