Search Results - "Tsui, Tung‐Yu"
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Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allografts
Published in The FASEB journal (01-04-2004)“…Biliverdin, a product of heme oxygenase‐1 (HO‐1) enzymatic action, is converted into bilirubin, which has been considered a waste product in the past. We now…”
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Cytoglobin Overexpression Protects against Damage-Induced Fibrosis
Published in Molecular therapy (01-06-2006)“…Cytoglobin (Cygb), a member of the hexacoordinate globin superfamily (hxHb), is expressed in fibroblasts from a broad range of tissues. The physiological…”
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3
Carbon monoxide, a two-face for the protection of the liver
Published in Current pharmaceutical biotechnology (01-05-2012)“…Carbon monoxide is generally believed to be a 'toxic' gas molecule due to its binding capability with hemoglobin. Overexposure to carbon monoxide leads to a…”
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4
Intracellular Delivery of Molecular Cargo Using Cell-Penetrating Peptides and the Combination Strategies
Published in International journal of molecular sciences (18-08-2015)“…Cell-penetrating peptides (CPPs) can cross cellular membranes in a non-toxic fashion, improving the intracellular delivery of various molecular cargos such as…”
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5
Carbon monoxide inhalation rescues mice from fulminant hepatitis through improving hepatic energy metabolism
Published in Shock (Augusta, Ga.) (01-02-2007)“…Heme oxygenase 1 (HO-1) enhances cellular antioxidative capability by increasing the cleavage of the endogenous and exogenous heme. Besides the biochemical…”
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rAAV-mediated stable expression of heme oxygenase-1 in stellate cells : A new approach to attenuate liver fibrosis in rats
Published in Hepatology (Baltimore, Md.) (01-08-2005)“…Liver fibrosis is the consequence of activation of hepatic stellate cells mediated by persistent or recurrent liver injury, where oxidative stress or…”
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Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats
Published in World journal of gastroenterology : WJG (07-04-2006)“…AIM: To test the hypothesis that enhancement of the activity of heine oxygenase can interfere with processes of fibrogenesis associated with recurrent liver…”
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The functional relevance of passenger leukocytes and microchimerism for heart allograft acceptance in the rat
Published in Nature medicine (01-11-1999)“…With an organ transplant, hematopoietic donor cells are transferred to the recipient. To study the relevance of the resulting microchimerism for allograft…”
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Prevention of chronic deterioration of heart allograft by recombinant adeno-associated virus-mediated heme oxygenase-1 gene transfer
Published in Circulation (New York, N.Y.) (27-05-2003)“…Allograft deterioration is the major obstacle to organ transplantation as a long-term treatment of end-stage heart failure. In this study, we transduced the…”
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10
Highly efficient delivery of siRNA to a heart transplant model by a novel cell penetrating peptide-dsRNA binding domain
Published in International journal of pharmaceutics (20-07-2014)“…[Display omitted] Small interfering RNAs (siRNAs) delivery remains a bottleneck for RNA interference (RNAi) – based therapies in the clinic. In the present…”
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lncRNA KCNQ1OT1 Suppresses the Inflammation and Proliferation of Vascular Smooth Muscle Cells through IκBa in Intimal Hyperplasia
Published in Molecular therapy. Nucleic acids (05-06-2020)“…Inflammation and proliferation of vascular smooth muscle cells (VSMCs) are the key events in intimal hyperplasia. This study aimed to explore the mechanism by…”
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12
Heme Oxygenase-1 Modulates the Expression of Adhesion Molecules Associated with Endothelial Cell Activation
Published in The Journal of immunology (1950) (15-03-2004)“…Heme oxygenase-1 (HO-1) cleaves the porphyrin ring of heme into carbon monoxide, Fe2+, and biliverdin, which is then converted into bilirubin. Heme-derived…”
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Targeting of interleukin-10 is superior to cytotoxic T-lymphocyte associated antigen 4 with human immunoglobulin G1 for the prevention of chronic allograft deterioration in organ transplantation
Published in The journal of gene medicine (01-12-2008)“…Background Genetic manipulation of the allograft is an attractive approach to prevent the graft against chronic deterioration through stable expression of…”
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Prevention and Management of CMV Infections after Liver Transplantation: Current Practice in German Transplant Centers
Published in Journal of clinical medicine (23-07-2020)“…Human cytomegalovirus (CMV) remains a major cause of mortality and morbidity in human liver transplant recipients. Anti-CMV therapeutics can be used to prevent…”
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Recombinant adeno-associated virus vector: Is it ideal for gene delivery in liver transplantation?
Published in Liver transplantation (01-04-2003)“…Recombinant adeno-associated virus vector (rAAV) is an effective and safe gene-delivery tool. However, its application in solid-organ transplantation has not…”
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Posterior cavoplasty: a new approach to avoid venous outflow obstruction and symptoms for small-for-size syndrome in right lobe living donor liver transplantation
Published in Langenbeck's archives of surgery (01-03-2011)“…Purpose A common and serious problem after living donor liver transplantation (LDLT) of small grafts is small-for-size syndrome (SFSS). Although hyperdynamic…”
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"Rescue allocation offers" in liver transplantation: Is there any reason to reject "unwanted" organs?
Published in Scandinavian journal of gastroenterology (01-12-2010)“…Abstract To increase the number of transplanted organs, the Eurotransplant foundation uses a so-called "rescue-organ-allocation" procedure for organs that had…”
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Bilirubin derived from heme degradation suppresses MHC class II expression in endothelial cells
Published in Biochemical and biophysical research communications (16-12-2005)“…The enzymatic action of heme oxygenase (HO) is mediated by the cleavage of heme into carbon monoxide, ferrous iron, and biliverdin/bilirubin. Here, we show…”
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Heme oxygenase-1-derived carbon monoxide stimulates adenosine triphosphate generation in human hepatocyte
Published in Biochemical and biophysical research communications (28-10-2005)“…Heme oxygenases cleave the pro-oxidant heme molecule into carbon monoxide, ferrous iron, and biliverdin, which is subsequently converted to bilirubin…”
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Adult living donor liver transplantation: body mass index and MELD score of recipients are independent risk factors for hospital mortality
Published in Langenbeck's archives of surgery (01-03-2009)“…Background and aims Adult living donor liver transplantation (LDLT) has been established as elective procedure or urgent procedure to save the life of patients…”
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