Search Results - "Tsui, Florence W. L"

The role of LCN2 and LCN2-MMP9 in spondylitis radiographic development: gender and HLA-B27 status differences by Tsui, Florence W. L, Lin, Aifeng, Sari, Ismail, Zhang, Zhenbo, Pritzker, Kenneth P. H, Tsui, Hing Wo, Inman, Robert D

“…Background Male HLA-B27-positive radiographic-axial spondyloarthritis (r-axSpA) patients are prone to have severe spinal radiographic progression, but the…”
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Serial Lipocalin 2 and Oncostatin M levels reflect inflammation status and treatment response in axial spondyloarthritis by Tsui, Florence W L, Lin, Aifeng, Sari, Ismail, Zhang, Zhenbo, Tsui, Hing Wo, Inman, Robert D

“…Informative serum biomarkers for monitoring inflammatory activity and treatment responses in axial spondyloarthritis (axSpA) are lacking. We assessed whether…”
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Radiographic severity of ankylosing spondylitis is associated with polymorphism of the large multifunctional peptidase 2 gene in the Spondyloarthritis Research Consortium of Canada cohort by Haroon, Nigil, Maksymowych, Walter P., Rahman, Proton, Tsui, Florence W. L., O'Shea, Finbar D., Inman, Robert D.

“…Objective There are limited data on genetic predictors of radiographic progression. The aim of this study was to examine polymorphisms in genes involved in…”
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Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain by Schlichter, Lyanne C, Jiang, Jiahua, Wang, John, Newell, Evan W, Tsui, Florence W L, Lam, Doris

“…Members of the EAG K(+) channel superfamily (EAG/Kv10.x, ERG/Kv11.x, ELK/Kv12.x subfamilies) are expressed in many cells and tissues. In particular, two…”
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Lipocalin 2 links inflammation and ankylosis in the clinical overlap of inflammatory bowel disease (IBD) and ankylosing spondylitis (AS) by Lin, Aifeng, Inman, Robert D, Streutker, Catherine J, Zhang, Zhenbo, Pritzker, Kenneth P H, Tsui, Hing Wo, Tsui, Florence W L

“…Little is known about the mechanisms underlying the clinical overlap between gut inflammation and joint ankylosis, as exemplified by the concurrence of…”
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Genetics and Mechanisms of Crystal Deposition in Calcium Pyrophosphate Deposition Disease by Tsui, Florence W. L.

“…Calcium pyrophosphate deposition (CPPD) disease (common in older adults) can be asymptomatic, associated with osteoarthritis, or can present as acute/chronic…”
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Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis by Tsui, Florence W L, Haroon, Nigil, Reveille, John D, Rahman, Proton, Chiu, Basil, Tsui, Hing Wo, Inman, Robert D

“…To assess whether there is excess transmission of alleles from the ERAP1 ERAP2 locus in families with ankylosing spondylitis (AS). 199 multiplex families with…”
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Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration by Erwin, W Mark, Islam, Diana, Inman, Robert D, Fehlings, Michael G, Tsui, Florence W L

“…The relative resistance of non-chondrodystrophic (NCD) canines to degenerative disc disease (DDD) may be due to a combination of anabolic and anti-catabolic…”
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Retinol (vitamin A) and retinol-binding protein levels are decreased in ankylosing spondylitis: clinical and genetic analysis by O'SHEA, Finbar D, TSUI, Florence W. L, BASIL CHIU, HING WO TSUI, YAZDANPANAH, Mehrdad, INMAN, Robert D

“…OBJECTIVE: Retinol (vitamin A) plays an important role in bone structure and function. Treatment with retinoids has been associated with bone abnormalities…”
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Inhibition of alkaline phosphatase by cysteine: implications for calcium pyrophosphate dihydrate crystal deposition disease by SO, Pauline P. L, TSUI, Florence W. L, VIETH, Reinhold, TUPY, Jindra H, PRITZKER, Kenneth P. H

“…OBJECTIVE: Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, a common arthritis affecting the elderly, is characterized by the deposition of…”
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Serum Cytokine Receptors in Ankylosing Spondylitis: Relationship to Inflammatory Markers and Endoplasmic Reticulum Aminopeptidase Polymorphisms by HAROON, Nigil, TSUI, Florence W. L, CHIU, Basil, HING WO TSUI, INMAN, Robert D

“…Endoplasmic reticulum aminopeptidase (ERAP)1 is associated with ankylosing spondylitis (AS) and is known to be involved in the clipping of the cytokine…”
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Symptomatic Acute Reactive Arthritis After An Outbreak of Salmonella by ROHEKAR, Sherry, TSUI, Florence W. L, HING WO TSUI, XI, Nancy, RIARH, Reena, BILOTTA, Rose, INMAN, Robert D

“…Objective In 2005, 592 individuals in Ontario developed acute gastroenteritis, predominantly after consuming bean sprouts contaminated with Salmonella…”
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The CPPDD-Associated ANKH M48T Mutation Interrupts the Interaction of ANKH with the Sodium/Phosphate Cotransporter PiT-1 by Wang, John, Tsui, Hing Wo, Beier, Frank, Tsui, Florence W L

“…Objective. Numerous dominant human homolog of progressive ankylosis ( ANKH ) mutations have been identified in familial calcium pyrophosphate dihydrate crystal…”
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Aberrant Chondrocyte Hypertrophy and Activation of β-Catenin Signaling Precede Joint Ankylosis in ank/ank Mice by FACUNDO LAS HERAS, PRITZKER, Kenneth P. H, SO, Anthony, HING WO TSUI, CHIU, Basil, INMAN, Robert D, TSUI, Florence W. L

“…We assessed the role of Ank in the maintenance of postnatal articular cartilage using the ank/ank mouse (mice homozygous for progressive ankylosis). We…”
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Investigations into the regulation and function of the SH2 domain-containing protein-tyrosine phosphatase, SHP-1 by Tsui, Florence W L, Martin, Alberto, Wang, John, Tsui, Hing Wo

“…Our laboratory is interested in identifying genes relevant to diseases. Our approach is to use spontaneous mouse mutants with immunological defects and…”
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Serum levels of novel noggin and sclerostin-immune complexes are elevated in ankylosing spondylitis by Tsui, Florence W L, Tsui, Hing Wo, Las Heras, Facundo, Pritzker, Kenneth P H, Inman, Robert D

“…Unravelling the basis of joint inflammation and ankylosis represents a major challenge in ankylosing spondylitis (AS) research. As noggin (NOG) and sclerostin…”
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Aberrant axial mineralization precedes spinal ankylosis: a molecular imaging study in ank/ank mice by Las Heras, Facundo, DaCosta, Ralph S, Pritzker, Kenneth P H, Haroon, Nigil, Netchev, George, Tsui, Hing Wo, Chiu, Basil, Erwin, W Mark, Tsui, Florence W L, Inman, Robert D

“…The diagnosis of ankylosing spondylitis is made from a combination of clinical features and the presence of radiographic evidence that may be detected only…”
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Microcytosis in ank/ank mice and the role of ANKH in promoting erythroid differentiation by Wang, John, Wang, Chen, Tsui, Hing Wo, Las Heras, Facundo, Cheng, Emily Y., Iscove, Norman N., Chiu, Basil, Inman, Robert D., Pritzker, Kenneth P.H., Tsui, Florence W.L.

“…Progressive ankylosis (Ank and the human homolog, ANKH) is a transmembrane protein which regulates transport of inorganic pyrophosphate (PPi). ank/ank mice…”
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Functional Up-regulation of HERG K+ Channels in Neoplastic Hematopoietic Cells by Smith, Garth A.M., Tsui, Hing-Wo, Newell, Evan W., Jiang, Xinpo, Zhu, Xiao-Ping, Tsui, Florence W.L., Schlichter, Lyanne C.

“…Kv1.3 channels regulate proliferation of normal lymphocytes, but the role of voltage-gated potassium channels in transformed hematopoietic cells is not known…”
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Association of a TNAP haplotype with ankylosing spondylitis by Tsui, Hing Wo, Inman, Robert D., Reveille, John D., Tsui, Florence W. L.

“…Objective To use a candidate gene approach to the identification of genetic markers that are significantly associated with ankylosing spondylitis (AS). Methods…”
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