Search Results - "Tsui, Dana W."

Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer by Dawson, Sarah-Jane, Tsui, Dana W.Y, Murtaza, Muhammed, Biggs, Heather, Rueda, Oscar M, Chin, Suet-Feung, Dunning, Mark J, Gale, Davina, Forshew, Tim, Mahler-Araujo, Betania, Rajan, Sabrina, Humphray, Sean, Becq, Jennifer, Halsall, David, Wallis, Matthew, Bentley, David, Caldas, Carlos, Rosenfeld, Nitzan

“…This study evaluated the sensitivity of assaying tumor DNA circulating in the plasma to monitor breast cancer. This assay is compared with three other…”
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Genome-wide mutational signatures in low-coverage whole genome sequencing of cell-free DNA by Wan, Jonathan C. M., Stephens, Dennis, Luo, Lingqi, White, James R., Stewart, Caitlin M., Rousseau, Benoît, Tsui, Dana W. Y., Diaz, Luis A.

“…Mutational signatures accumulate in somatic cells as an admixture of endogenous and exogenous processes that occur during an individual’s lifetime. Since…”
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Age at cancer diagnosis by breed, weight, sex, and cancer type in a cohort of more than 3,000 dogs: Determining the optimal age to initiate cancer screening in canine patients by Rafalko, Jill M, Kruglyak, Kristina M, McCleary-Wheeler, Angela L, Goyal, Vidit, Phelps-Dunn, Ashley, Wong, Lilian K, Warren, Chelsea D, Brandstetter, Gina, Rosentel, Michelle C, DiMarzio, Lauren, McLennan, Lisa M, O'Kell, Allison L, Cohen, Todd A, Grosu, Daniel S, Chibuk, Jason, Tsui, Dana W Y, Chorny, Ilya, Flory, Andi

“…The goal of cancer screening is to detect disease at an early stage when treatment may be more effective. Cancer screening in dogs has relied upon annual…”
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Predicting tumour content of liquid biopsies from cell-free DNA by Cardner, Mathias, Marass, Francesco, Gedvilaite, Erika, Yang, Julie L, Tsui, Dana W Y, Beerenwinkel, Niko

“…Liquid biopsy is a minimally-invasive method of sampling bodily fluids, capable of revealing evidence of cancer. The distribution of cell-free DNA (cfDNA)…”
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Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA by Murtaza, Muhammed, Dawson, Sarah-Jane, Tsui, Dana W. Y., Gale, Davina, Forshew, Tim, Piskorz, Anna M., Parkinson, Christine, Chin, Suet-Feung, Kingsbury, Zoya, Wong, Alvin S. C., Marass, Francesco, Humphray, Sean, Hadfield, James, Bentley, David, Chin, Tan Min, Brenton, James D., Caldas, Carlos, Rosenfeld, Nitzan

“…A proof of principle study shows that by exome sequencing of cell-free circulating DNA from cancer patient plasma samples, the genomic evolution of metastatic…”
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Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA by Forshew, Tim, Murtaza, Muhammed, Parkinson, Christine, Gale, Davina, Tsui, Dana W Y, Kaper, Fiona, Dawson, Sarah-Jane, Piskorz, Anna M, Jimenez-Linan, Mercedes, Bentley, David, Hadfield, James, May, Andrew P, Caldas, Carlos, Brenton, James D, Rosenfeld, Nitzan

“…Plasma of cancer patients contains cell-free tumor DNA that carries information on tumor mutations and tumor burden. Individual mutations have been probed…”
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Mutant-RB1 circulating tumor DNA in the blood of unilateral retinoblastoma patients: What happens during enucleation surgery: A pilot study by Abramson, David H, Mandelker, Diana L, Brannon, A Rose, Dunkel, Ira J, Benayed, Ryma, Berger, Michael F, Arcila, Maria E, Ladanyi, Marc, Friedman, Danielle Novetsky, Jayakumaran, Gowtham, Diosdado, Monica S, Robbins, Melissa A, Haggag-Lindgren, Dianna, Shukla, Neerav, Walsh, Michael F, Kothari, Prachi, Tsui, Dana W Y, Francis, Jasmine H

“…Cell free DNA (cfDNA) and circulating tumor cell free DNA (ctDNA) from blood (plasma) are increasingly being used in oncology for diagnosis, monitoring…”
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Development of Genome-Derived Tumor Type Prediction to Inform Clinical Cancer Care by Penson, Alexander, Camacho, Niedzica, Zheng, Youyun, Varghese, Anna M, Al-Ahmadie, Hikmat, Razavi, Pedram, Chandarlapaty, Sarat, Vallejo, Christina E, Vakiani, Efsevia, Gilewski, Teresa, Rosenberg, Jonathan E, Shady, Maha, Tsui, Dana W Y, Reales, Dalicia N, Abeshouse, Adam, Syed, Aijazuddin, Zehir, Ahmet, Schultz, Nikolaus, Ladanyi, Marc, Solit, David B, Klimstra, David S, Hyman, David M, Taylor, Barry S, Berger, Michael F

“…Diagnosing the site of origin for cancer is a pillar of disease classification that has directed clinical care for more than a century. Even in an era of…”
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Tumor fraction-guided cell-free DNA profiling in metastatic solid tumor patients by Tsui, Dana W Y, Cheng, Michael L, Shady, Maha, Yang, Julie L, Stephens, Dennis, Won, Helen, Srinivasan, Preethi, Huberman, Kety, Meng, Fanli, Jing, Xiaohong, Patel, Juber, Hasan, Maysun, Johnson, Ian, Gedvilaite, Erika, Houck-Loomis, Brian, Socci, Nicholas D, Selcuklu, S Duygu, Seshan, Venkatraman E, Zhang, Hongxin, Chakravarty, Debyani, Zehir, Ahmet, Benayed, Ryma, Arcila, Maria, Ladanyi, Marc, Funt, Samuel A, Feldman, Darren R, Li, Bob T, Razavi, Pedram, Rosenberg, Jonathan, Bajorin, Dean, Iyer, Gopa, Abida, Wassim, Scher, Howard I, Rathkopf, Dana, Viale, Agnes, Berger, Michael F, Solit, David B

“…Cell-free DNA (cfDNA) profiling is increasingly used to guide cancer care, yet mutations are not always identified. The ability to detect somatic mutations in…”
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Fragment Size Analysis May Distinguish Clonal Hematopoiesis from Tumor-Derived Mutations in Cell-Free DNA by Marass, Francesco, Stephens, Dennis, Ptashkin, Ryan, Zehir, Ahmet, Berger, Michael F, Solit, David B, Diaz, Luis A, Tsui, Dana W Y

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Clinical validation of a next-generation sequencing-based multi-cancer early detection "liquid biopsy" blood test in over 1,000 dogs using an independent testing set: The CANcer Detection in Dogs (CANDiD) study by Flory, Andi, Kruglyak, Kristina M, Tynan, John A, McLennan, Lisa M, Rafalko, Jill M, Fiaux, Patrick Christian, Hernandez, Gilberto E, Marass, Francesco, Nakashe, Prachi, Ruiz-Perez, Carlos A, Fath, Donna M, Jennings, Thuy, Motalli-Pepio, Rita, Wotrang, Kate, McCleary-Wheeler, Angela L, Lana, Susan, Phillips, Brenda, Flesner, Brian K, Leibman, Nicole F, LaDue, Tracy, Tripp, Chelsea D, Coomber, Brenda L, Woods, J Paul, Miller, Mairin, Aiken, Sean W, Wolf-Ringwall, Amber, Borgatti, Antonella, Kraska, Kathleen, Thomson, Christopher B, Kosanovich Cahalane, Alane, Murray, Rebecca L, Kisseberth, William C, Camps-Palau, Maria A, Floch, Franck, Beaudu-Lange, Claire, Klajer-Peres, Aurélia, Keravel, Olivier, Fribourg-Blanc, Luc-André, Mazetier, Pascale Chicha, Marco, Angelo, McLeod, Molly B, Portillo, Erin, Clark, Terry S, Judd, Scott, Feinberg, C Kirk, Benitez, Marie, Runyan, Candace, Hackett, Lindsey, Lafey, Scott, Richardson, Danielle, Vineyard, Sarah, Tefend Campbell, Mary, Dharajiya, Nilesh, Jensen, Taylor J, van den Boom, Dirk, Diaz, Jr, Luis A, Grosu, Daniel S, Polk, Arthur, Marsal, Kalle, Hicks, Susan Cho, Lytle, Katherine M, Holtvoigt, Lauren, Chibuk, Jason, Chorny, Ilya, Tsui, Dana W Y

“…Cancer is the leading cause of death in dogs, yet there are no established screening paradigms for early detection. Liquid biopsy methods that interrogate…”
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The value of cell‐free DNA for molecular pathology by Stewart, Caitlin M, Kothari, Prachi D, Mouliere, Florent, Mair, Richard, Somnay, Saira, Benayed, Ryma, Zehir, Ahmet, Weigelt, Britta, Dawson, Sarah‐Jane, Arcila, Maria E, Berger, Michael F, Tsui, Dana WY

“…Over the past decade, advances in molecular biology and genomics techniques have revolutionized the diagnosis and treatment of cancer. The technological…”
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Detection of Age-Related Somatic Alterations in Canine Blood Using Next-Generation Sequencing-Based Liquid Biopsy: An Analysis of over 4800 Dogs by Kruglyak, Kristina M, O'Kell, Allison L, Cohen, Todd A, Marshall, Maggie A, Ruiz-Perez, Carlos A, Marass, Francesco, Tynan, John A, Hicks, Susan C, Lytle, Katherine M, Phelps-Dunn, Ashley, Brandstetter, Gina, Warren, Chelsea D, DiMarzio, Lauren R, Rosentel, Michelle C, Wong, Lilian K, McLennan, Lisa M, Rafalko, Jill M, Grosu, Daniel S, Chibuk, Jason, Chorny, Ilya, McCleary-Wheeler, Angela L, Flory, Andi, Tsui, Dana W Y

“…Age-related somatic genomic alterations in hematopoietic cell lines have been well characterized in humans; however, this phenomenon has not been well studied…”
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Systematic identification of placental epigenetic signatures for the noninvasive prenatal detection of Edwards syndrome by Tsui, Dana W Y, Lam, Y M Doris, Lee, Wing S, Leung, Tak Y, Lau, Tze K, Lau, Elizabeth T, Tang, Mary H Y, Akolekar, Ranjit, Nicolaides, Kypros H, Chiu, Rossa W K, Lo, Y M Dennis, Chim, Stephen S C

“…Noninvasive prenatal diagnosis of fetal aneuploidy by maternal plasma analysis is challenging owing to the low fractional and absolute concentrations of fetal…”
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Horizons in Veterinary Precision Oncology: Fundamentals of Cancer Genomics and Applications of Liquid Biopsy for the Detection, Characterization, and Management of Cancer in Dogs by Chibuk, Jason, Flory, Andi, Kruglyak, Kristina M, Leibman, Nicole, Nahama, Alexis, Dharajiya, Nilesh, van den Boom, Dirk, Jensen, Taylor J, Friedman, Jeffrey S, Shen, M Richard, Clemente-Vicario, Francisco, Chorny, Ilya, Tynan, John A, Lytle, Katherine M, Holtvoigt, Lauren E, Murtaza, Muhammed, Diaz, Jr, Luis A, Tsui, Dana W Y, Grosu, Daniel S

“…Cancer is the leading cause of death in dogs, in part because many cases are identified at an advanced stage when clinical signs have developed, and prognosis…”
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Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid by Miller, Alexandra M., Shah, Ronak H., Pentsova, Elena I., Pourmaleki, Maryam, Briggs, Samuel, Distefano, Natalie, Zheng, Youyun, Skakodub, Anna, Mehta, Smrutiben A., Campos, Carl, Hsieh, Wan-Ying, Selcuklu, S. Duygu, Ling, Lilan, Meng, Fanli, Jing, Xiaohong, Samoila, Aliaksandra, Bale, Tejus A., Tsui, Dana W. Y., Grommes, Christian, Viale, Agnes, Souweidane, Mark M., Tabar, Viviane, Brennan, Cameron W., Reiner, Anne S., Rosenblum, Marc, Panageas, Katherine S., DeAngelis, Lisa M., Young, Robert J., Berger, Michael F., Mellinghoff, Ingo K.

“…Diffuse gliomas are the most common malignant brain tumours in adults and include glioblastomas and World Health Organization (WHO) grade II and grade III…”
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Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer by Murtaza, Muhammed, Dawson, Sarah-Jane, Pogrebniak, Katherine, Rueda, Oscar M., Provenzano, Elena, Grant, John, Chin, Suet-Feung, Tsui, Dana W. Y., Marass, Francesco, Gale, Davina, Ali, H. Raza, Shah, Pankti, Contente-Cuomo, Tania, Farahani, Hossein, Shumansky, Karey, Kingsbury, Zoya, Humphray, Sean, Bentley, David, Shah, Sohrab P., Wallis, Matthew, Rosenfeld, Nitzan, Caldas, Carlos

“…Circulating tumour DNA analysis can be used to track tumour burden and analyse cancer genomes non-invasively but the extent to which it represents metastatic…”
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The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes by Pereira, Bernard, Chin, Suet-Feung, Rueda, Oscar M, Vollan, Hans-Kristian Moen, Provenzano, Elena, Bardwell, Helen A, Pugh, Michelle, Jones, Linda, Russell, Roslin, Sammut, Stephen-John, Tsui, Dana W Y, Liu, Bin, Dawson, Sarah-Jane, Abraham, Jean, Northen, Helen, Peden, John F, Mukherjee, Abhik, Turashvili, Gulisa, Green, Andrew R, McKinney, Steve, Oloumi, Arusha, Shah, Sohrab, Rosenfeld, Nitzan, Murphy, Leigh, Bentley, David R, Ellis, Ian O, Purushotham, Arnie, Pinder, Sarah E, Børresen-Dale, Anne-Lise, Earl, Helena M, Pharoah, Paul D, Ross, Mark T, Aparicio, Samuel, Caldas, Carlos

“…The genomic landscape of breast cancer is complex, and inter- and intra-tumour heterogeneity are important challenges in treating the disease. In this study,…”
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Quantitative aberrations of hypermethylated RASSF1A gene sequences in maternal plasma in pre-eclampsia by Tsui, Dana W. Y., Chan, K. C. Allen, Chim, Stephen S. C., Chan, Lin-wai, Leung, Tak-yeung, Lau, Tze-kin, Lo, Y. M. Dennis, Chiu, Rossa W. K.

“…Objective To study if quantitative aberrations in circulating placental‐derived hypermethylated RASSF1A DNA in maternal plasma are associated with…”
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Circulating cell-free DNA for non-invasive cancer management by Stewart, Caitlin M., Tsui, Dana W.Y.

“…•Cell-free nucleic acids in body fluids contain tumour fragments that can be profiled for prognostic and diagnostic information for the management of…”
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