Rhodium-catalyzed Synthesis of Benzo[b]thiophene-3-carboxamides via Cyclization of (ortho-Alkynyl)phenyl Sulfides in the Presence of Isocyanates

A facile synthesis of benzo[b]thiophene-3-carboxamides from (ortho-alkynyl)phenyl methoxymethyl sulfides and isocyanates was realized. The method involves a tandem-type, cyclization–addition sequence in the presence of a rhodium catalyst. The reactions proceed under considerably mild conditions (roo...

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Bibliographic Details
Published in:	Chemistry letters Vol. 48; no. 5; pp. 468 - 470
Main Authors:	Mizukami, Akiho, Tsugita, Maika, Shimora, Mako, Tanaka, Saki, Hayama, Noboru, Kimachi, Tetsutaro, Inamoto, Kiyofumi
Format:	Journal Article
Language:	English
Published:	Tokyo The Chemical Society of Japan 05-05-2019 Chemical Society of Japan
Subjects:	Benzothiophene Catalysis Chemical synthesis Isocyanates Rhodium Sulfides Tandem process Rhodium catalysis Benzo[b]thiophene
Online Access:	Get full text
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Summary:	A facile synthesis of benzo[b]thiophene-3-carboxamides from (ortho-alkynyl)phenyl methoxymethyl sulfides and isocyanates was realized. The method involves a tandem-type, cyclization–addition sequence in the presence of a rhodium catalyst. The reactions proceed under considerably mild conditions (room temperature to 50 °C), providing an efficient and entirely new route to substituted benzo[b]thiophene-3-carboxamide derivatives.
ISSN:	0366-7022 1348-0715
DOI:	10.1246/cl.190043