Search Results - "Tsuda, Minoru"

Absorption, metabolism, and excretion of [14C]dersimelagon, an investigational oral selective melanocortin 1 receptor agonist, in preclinical species and healthy volunteers by Tsuda, Minoru, Ogawa, Kei, Endou, Tadashi, Goto, Takahiro, Ogasawara, Yuko, Ogasawara, Akihito

“…Dersimelagon (formerly MT‐7117) is a novel, orally administered nonpeptide small molecule selective agonist for melanocortin 1 receptor currently being…”
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Intestinal Sodium Glucose Cotransporter 1 Inhibition Enhances Glucagon-Like Peptide-1 Secretion in Normal and Diabetic Rodents by Oguma, Takahiro, Nakayama, Keiko, Kuriyama, Chiaki, Matsushita, Yasuaki, Yoshida, Kumiko, Hikida, Kumiko, Obokata, Naoyuki, Tsuda-Tsukimoto, Minoru, Saito, Akira, Arakawa, Kenji, Ueta, Kiichiro, Shiotani, Masaharu

“…The sodium glucose cotransporter (SGLT) 1 plays a major role in glucose absorption and incretin hormone release in the gastrointestinal tract; however, the…”
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Molecular Cloning and Characterization of a New Multispecific Organic Anion Transporter from Rat Brain by Kusuhara, Hiroyuki, Sekine, Takashi, Utsunomiya-Tate, Naoko, Tsuda, Minoru, Kojima, Ryoji, Cha, Seok Ho, Sugiyama, Yuichi, Kanai, Yoshikatsu, Endou, Hitoshi

“…A cDNA encoding the new member of the multispecific organic anion transporter family, OAT3, was isolated by the reverse transcription-polymerase chain reaction…”
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Changes in glucose-induced plasma active glucagon-like peptide-1 levels by co-administration of sodium–glucose cotransporter inhibitors with dipeptidyl peptidase-4 inhibitors in rodents by Oguma, Takahiro, Kuriyama, Chiaki, Nakayama, Keiko, Matsushita, Yasuaki, Hikida, Kumiko, Tsuda-Tsukimoto, Minoru, Saito, Akira, Arakawa, Kenji, Ueta, Kiichiro, Minami, Masabumi, Shiotani, Masaharu

“…We investigated whether structurally different sodium–glucose cotransporter (SGLT) 2 inhibitors, when co-administered with dipeptidyl peptidase-4 (DPP4)…”
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Interactions of Organic Anion Transporters and Organic Cation Transporters With Mycotoxins by Tachampa, Kittipong, Takeda, Michio, Khamdang, Suparat, Noshiro-Kofuji, Rie, Tsuda, Minoru, Jariyawat, Surawat, Fukutomi, Toshiyuki, Sophasan, Samaisukh, Anzai, Naohiko, Endou, Hitoshi

“…Mycotoxins are secondary metabolites of moulds that which exert adverse effects in humans and animals. It is known that direct cellular toxicity is often…”
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Effect of Plasma Protein Binding on in Vitro-in Vivo Correlation of Biliary Excretion of Drugs Evaluated by Sandwich-Cultured Rat Hepatocytes by FUKUDA, Hajime, OHASHI, Rikiya, TSUDA-TSUKIMOTO, Minoru, TAMAI, Ikumi

“…In the present study, we examined in vitro biliary clearance of several compounds in sandwich-cultured rat hepatocytes (SCRH) and compared it with that…”
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Identification of multispecific organic anion transporter 2 expressed predominantly in the liver by Sekine, Takashi, Cha, Seok Ho, Tsuda, Minoru, Apiwattanakul, Nopporn, Nakajima, Noriko, Kanai, Yoshikatsu, Endou, Hitoshi

“…In the present study, we demonstrate that NLT (novel liver-specific transport protein) is a multispecific organic anion transporter of the liver. The amino…”
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Molecular dynamics simulations of Gly-12-->Val mutant of p21(ras): dynamic inhibition mechanism by Futatsugi, N, Tsuda, M

“…The mutant p21(ras) protein is a G protein produced by the point-mutated H-ras gene, and this mutant protein has been shown to cause carcinogenesis due to a…”
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Impact of Intestinal Glucuronidation on the Pharmacokinetics of Raloxifene by KOSAKA, Keigo, SAKAI, Norifumi, KUME, Toshiyuki, ENDO, Yuya, FUKUHARA, Yuga, TSUDA-TSUKIMOTO, Minoru, OHTSUKA, Tatsuyuki, KINO, Ichiro, TANIMOTO, Tomohiko, TAKEBA, Naomi, TAKAHASHI, Masakatsu

“…Raloxifene is extensively glucuronidated in humans, effectively reducing its oral bioavailability (2%). It was also reported to be glucuronidated in…”
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Na+-Glucose Cotransporter (SGLT) Inhibitors as Antidiabetic Agents. 4. Synthesis and Pharmacological Properties of 4‘-Dehydroxyphlorizin Derivatives Substituted on the B Ring by Tsujihara, Kenji, Hongu, Mitsuya, Saito, Kunio, Kawanishi, Hiroyuki, Kuriyama, Kayoko, Matsumoto, Mamoru, Oku, Akira, Ueta, Kiichiro, Tsuda, Minoru, Saito, Akira

“…In our studies of Na+-glucose cotransporter (SGLT) inhibitors as antidiabetic agents, a series of novel 4‘-dehydroxyphlorizin derivatives substituted on the B…”
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Theoretical Studies of the ATP Hydrolysis Mechanism of Myosin by Okimoto, Noriaki, Yamanaka, Kazunori, Ueno, Junko, Hata, Masayuki, Hoshino, Tyuji, Tsuda, Minoru

“…The ATP hydrolysis mechanism of myosin was studied using quantum chemical (QM) and molecular dynamics calculations. The initial model compound for QM…”
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Transport of ochratoxin A by renal multispecific organic anion transporter 1 by Tsuda, M, Sekine, T, Takeda, M, Cha, S H, Kanai, Y, Kimura, M, Endou, H

“…In the present study, we investigated the transport of ochratoxin A (OTA) by kidney-specific organic anion transporter 1 (OAT1). When expressed in Xenopus…”
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Molecular Cloning and Characterization of High-Affinity Carnitine Transporter from Rat Intestine by Sekine, Takashi, Kusuhara, Hiroyuki, Utsunomiya-Tate, Naoko, Tsuda, Minoru, Sugiyama, Yuichi, Kanai, Yoshikatsu, Endou, Hitoshi

“…Carnitine is an essential component for mitochondrial β-oxidation of fatty acid. Using the degenerate primers designed for organic anion transporters and an…”
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Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 and 2B22 in COS-7 cells enhances UDP-glucuronosyltransferase 2B21-catalyzed morphine-6-glucuronide formation by Ishii, Y, Miyoshi, A, Watanabe, R, Tsuruda, K, Tsuda, M, Yamaguchi-Nagamatsu, Y, Yoshisue, K, Tanaka, M, Maji, D, Ohgiya, S, Oguri, K

“…Although UDP-glucuronosyltransferases (UGTs) act as an important detoxification system for many endogenous and exogenous compounds, they are also involved in…”
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Theoretical Study on Compound I Formation in Monooxygenation Mechanism by Cytochrome P450 by Hata, Masayuki, Hirano, Yoshinori, Hoshino, Tyuji, Nishida, Rie, Tsuda, Minoru

“…The intermediate structures appearing until compound I formation in the monooxygenation reaction cycle by cytochrome P450 were determined by using the density…”
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A Study on the Mechanism of the Proton Transport in Bacteriorhodopsin: The Importance of the Water Molecule by Murata, Katsumi, Fujii, Yasuyuki, Enomoto, Nobuyuki, Hata, Masayuki, Hoshino, Tyuji, Tsuda, Minoru

“…The mechanism of proton transport around the Schiff base in bacteriorhodopsin was investigated by ab initio molecular orbital (MO) calculations. Computations…”
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Role of Human Liver Cytochrome P450 2C9 in the Metabolism of a Novel α4β1/α4β7 Dual Antagonist, TR-14035 by Tsuda-Tsukimoto, Minoru, Ogasawara, Yuko, Kume, Toshiyuki

“…The metabolism of a novel dual antagonist for α4β1/α4β7 integrin, TR-14035, and the role of polymorphic enzyme responsible for this metabolism were…”
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Substrate Deacylation Mechanisms of Serine-β-lactamases by Hata, Masayuki, Fujii, Yasuyuki, Tanaka, Yoshikazu, Ishikawa, Hidenori, Ishii, Miho, Neya, Saburo, Tsuda, Minoru, Hoshino, Tyuji

“…The substrate deacylation mechanisms of serine-β-lactamases (classes A, C and D) were investigated by theoretical calculations. The deacylation of class A…”
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Hydrolysis Mechanism of the Phenylalanine−Proline Peptide Bond Specific to HIV-1 Protease:  Investigation by the ab Initio Molecular Orbital Method by Okimoto, Noriaki, Tsukui, Toshiyuki, Hata, Masayuki, Hoshino, Tyuji, Tsuda, Minoru

“…The protein hydrolysis mechanism by the HIV-1 protease (HIV-1 PR) was studied using ab initio molecular orbital calculations with a model compound. The initial…”
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Ab Initio Study of the Role of Lysine 16 for the Molecular Switching Mechanism of Ras Protein p21 by Futatsugi, Noriyuki, Hata, Masayuki, Hoshino, Tyuji, Tsuda, Minoru

“…Quantum chemical computations using the ab initio molecular orbital (MO) method have been performed to investigate the molecular switching mechanism of Ras…”
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